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Preparation method for moisturizing spray containing water-soluble cannabidiol

A cannabidiol, moisturizing spray technology, applied in skin care preparations, pharmaceutical formulations, cosmetic preparations and other directions, can solve the problems of limiting the amount of addition, failing to achieve skin care effects, etc., achieving comprehensive nutritional effects and improving dry skin problems , the effect of simple preparation process

Inactive Publication Date: 2020-01-10
YUNNAN LVXIN BIOLOGICAL PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Through a comparative study of various skin care products about cannabidiol, it is found that cannabidiol, the main additive of existing skin care products containing industrial hemp extract, is a fat-soluble substance. For most cosmetics with high water content, cannabidiol The low solubility of phenol severely limits its addition amount, so that the ideal skin care effect cannot be achieved

Method used

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  • Preparation method for moisturizing spray containing water-soluble cannabidiol

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Preparation of water-soluble cannabidiol

[0032] (1) Accurately weigh 2g of CBD powder and add it to 10g of ethanol, fully stir and dissolve to obtain an organic phase containing CBD.

[0033] (2) Accurately weigh 4.76g of albumin and dissolve it in 100g of deionized water, stir and add slight heat to fully dissolve to obtain an aqueous solution of albumin. Add 1 mol / L hydrochloric acid dropwise to adjust the pH value of the albumin aqueous solution to 6.0, add 1 g of ethanol, stir and mix evenly to obtain an aqueous phase.

[0034] (3) Put the above water phase in a 30°C water bath, and stir mechanically at a speed of 5000r / min. After the temperature stabilized, the organic phase was slowly added dropwise into the water phase, and fully stirred for 3 hours to obtain an oil-in-water emulsion solution.

[0035] (4) Transfer the oil-in-water emulsion solution to a high-pressure micro-fluidic nanodisperser for high-pressure homogenization. The homogenization pressure i...

Embodiment 2

[0044] Preparation of water-soluble cannabidiol

[0045] With embodiment 1.

[0046] Preparation of water-soluble cannabidiol moisturizing spray

[0047] (1) Take a 250ml round bottom flask, add 58.1g of deionized water and 30g of jasmine flower water to it in sequence, place it in a water bath at 70°C, and stir.

[0048] (2) After the temperature stabilized, accurately weigh 0.1g EDTA-2Na and 0.1g menthol into the flask, stir until dissolved; then add 2.2g oat-β-glucan and 0.45g sodium hyaluronate in sequence.

[0049] (3) After the solution is clarified, dissolve 0.05g of xanthan gum in a mixture of 2.5g of glycerin and 3g of butanediol, add it to the flask, stir until completely dissolved, and adjust the temperature of the water bath to 50°C.

[0050] (4) When the temperature drops to 50°C, add 1.6g of water-soluble CBD, 0.6g of nicotinamide, 0.5g of palmitoyl oligopeptide, and 0.5g of carnosine in sequence. After the dissolution is complete, cool to room temperature; add...

Embodiment 3

[0052] Preparation of water-soluble cannabidiol

[0053] With embodiment 1.

[0054] Preparation of water-soluble cannabidiol moisturizing spray

[0055] (1) Take a 250ml round bottom flask, add 56.5g of deionized water and 30g of jasmine flower water to it in sequence, place it in a water bath at 70°C, and stir.

[0056] (2) After the temperature stabilized, accurately weigh 0.1g EDTA-2Na and 0.1g menthol into the flask, stir until dissolved; then add 2.2g oat-β-glucan and 0.45g sodium hyaluronate in sequence.

[0057] (3) After the solution is clarified, dissolve 0.05g of xanthan gum in a mixture of 2.5g of glycerin and 3g of butanediol, add it to the flask, stir until completely dissolved, and adjust the temperature of the water bath to 50°C.

[0058] (4) When the temperature drops to 50°C, add 3.2g of water-soluble CBD, 0.6g of nicotinamide, 0.5g of palmitoyl oligopeptide, and 0.5g of carnosine in sequence. After the dissolution is complete, cool to room temperature; add...

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Abstract

The invention belongs to the field of daily cosmetics, and particularly relates to a preparation method for a moisturizing spray containing water-soluble cannabidiol. The moisturizing spray is composed of the following raw materials: 35 to 50 parts of deionized water, 20 to 45 parts of jasmine flower water, 2 to 8 parts of glycerol, 2 to 8 parts of butanediol, 0.5 to 3 parts of oat-beta-glucan, 0.1 to 10 parts of the water-soluble cannabidiol, 0.05 to 0.6 part of sodium hyaluronate, 0.1 to 1 part of nicotinamide, 0.1 to 1 part of palmitoyl oligopeptide, 0.1 to 1 part of carnosine, 0.2 to 0.8 part of xanthan gum, 0.05 to 0.5 part of menthol, 0.1 to 0.5 part of EDTA-2Na, and 0.1 to 0.3 part of ethylparaben. According to the method, fat-soluble cannabidiol is encapsulated by a water-soluble packaging material, so that the addition amount of the cannabidiol in the spray is increased, and the moisturizing spray provided by the invention has excellent anti-inflammatory, wrinkle-removing, moisturizing and whitening effects.

Description

technical field [0001] The invention belongs to the field of daily cosmetics, and in particular relates to a preparation method of a moisturizing spray containing water-soluble cannabidiol. Background technique [0002] Marijuana (Cannabis sativa L.), also known as hemp or thread hemp, is a plant of the family Moraceae and the genus Cannabis. It is an annual erect herb with a height of 1 to 3 meters. According to the proportion of tetrahydrocannabinol (THC) contained in cannabis, it is usually divided into two categories: industrial cannabis and drug cannabis. Industrial hemp belongs to low-toxic cannabis, wherein the content of tetrahydrocannabinol (THC) is the highest not exceeding 0.3%, and has no drug utilization value; while the content of tetrahydrocannabinol (THC) in the leaves and flower branches of drug cannabis is relatively high. High, a highly toxic marijuana. At present, there are more than 80 kinds of cannabinoids (CBs) isolated from cannabis, mainly includin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/04A61K8/34A61K8/37A61K8/44A61K8/64A61K8/67A61K8/73A61K8/9789A61Q19/00A61Q19/02A61Q19/08
CPCA61K8/046A61K8/34A61K8/345A61K8/347A61K8/37A61K8/44A61K8/64A61K8/675A61K8/73A61K8/735A61K8/9789A61Q19/00A61Q19/02A61Q19/08
Inventor 王钲霖刘胜贵付彬彬李智高孔令羽
Owner YUNNAN LVXIN BIOLOGICAL PHARMA CO LTD
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