A kind of one pot two-step method prepares the method for quinoline derivative

Abstract

The invention relates to a method for preparing quinoline derivatives in one pot and two steps. The method uses aromatic nitro compounds and aliphatic alcohols as raw materials, uses oxygen-containing molybdenum disulfide as a catalyst, and first reacts for 2 to 10 hours under the conditions of 0.3-3.0 MPa hydrogen and 120-160 ° C to convert aromatic nitro compounds into aromatic amines. , then replace the reaction atmosphere, react in an inert atmosphere or an oxygen-containing atmosphere at 120-200°C for 2-12 hours, after the reaction is completed, separate the liquid phase components, concentrate, and separate through a silica gel column to obtain a substituted quinoline compound. This synthesis method may have important applications in the synthesis of quinoline compounds.

Description

A kind of method for preparing quinoline derivatives by one-pot two-step method technical field The invention belongs to technical field of organic synthesis, be specifically related to a kind of method for preparing quinoline derivative by one-pot two-step method Law. Background technique Quinoline compounds and derivatives thereof are a class of important organic compounds, which are widely used in functional medicines, Synthesis of pesticides, dyes, chemical reagents, optical materials and functional polymers (Andries K et al.Science.2005; 307(5707):223‑27; Theeraladanon C et al. Tetrahedron:Asymmetry. 2005;16(4):827‑ 31; Roma G et al. European Journal of Medicinal Chemistry. 2000; 35(11): 1021‑35; Zhang X J et al. Macromolecules. 1999;32(22):7422‑29). Its synthesis method has been widely of widespread concern, among which there is no lack of organic Skraup reactions (Organic Reactions. 1953; 7: 59-98), Doebner reaction (J.Chem.Soc. 1934:1520-23), Doebner-V...

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Problems solved by technology

[0003] However, this strategy for the direct synthesis of quinolines was later proved to be rather difficult, mainly due to the complexity of the cascade reactions

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