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Skin care product suitable for skins of diabetic patients

A technology for skin care products and diabetes, applied in skin care preparations, skin diseases, medical preparations containing active ingredients, etc., to achieve huge application value, beneficial to tissue repair and regeneration, and good application prospects

Active Publication Date: 2020-02-11
KUNMING MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This shows that although the American cockroach extract can improve and moisturize the skin, it has been found in practice that frequent and excessive use of products containing natural components of the American cockroach extract will cause side effects, which will cause excessive proliferation of granulation tissue and collagen fiber deposition such as image 3 (A), resulting in skin scarring

Method used

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  • Skin care product suitable for skins of diabetic patients
  • Skin care product suitable for skins of diabetic patients
  • Skin care product suitable for skins of diabetic patients

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Embodiment 1 raw material preparation

[0048] 1.1 Preparation of Periplaneta americana Extract

[0049] 1.1.1 Extraction of Periplaneta americana Extract 1

[0050] The extraction method of the Periplaneta americana extract is as follows: select the adults of Periplaneta americana with full worm bodies, and dry them in a dryer at 60°C; soak in 10 times the amount of 95% ethanol as a solvent for 2 weeks; reflux extraction with ethanol 3 times, each The extraction time is 1 hour, the remaining extract is soaked in 10 times the volume of aqueous solution for 4 hours, and then extracted twice, the extraction time is 1 hour respectively, the water extraction solution is combined, concentrated under reduced pressure and dried to obtain the water extract, i.e. Periplaneta americana Extract.

[0051] 1.1.2 Extraction of Periplaneta americana Extract 2

[0052] The difference from 1.1.1 is: the drying temperature is 80°C, 8 times the amount of 95% ethanol is used as a solven...

Embodiment 2

[0058] Example 2: The effect of Periplaneta americana extract on scratch healing of vascular endothelial cells

[0059] In order to observe the effect of Periplaneta americana extract on the proliferation and angiogenesis of vascular endothelial cells, 2.0×10 6 Inoculate the vascular endothelial cell line—Human Umbilical Vein Endothelial Cells (HUVEC) at a density of 1 cell / mL in a six-well plate with 2ml of F-12K medium containing 10% fetal bovine serum and 1% penicillin / streptomycin per well , and incubated in a cell culture incubator. After the cells attach, use the tip of a sterile 10 μl pipette to make a cell scratch, and gently wash away cells floating from the scratch with PBS. Different concentrations of Periplaneta americana extract were used to treat cells and observe its healing effect on scratches, and serum-free medium without samples was used as blank control. Photographs of scratches were taken at 0, 12 and 24 h using an inverted microscope, and width measurem...

Embodiment 3

[0061] The preparation of embodiment 3 face creams and to diabetic patient skin care efficacy test

[0062] 3.1 Preparation method of face cream

[0063] 3.1.1 Preparation of face cream 1

[0064] (1) Raw materials are prepared according to mass percentage: Periplaneta americana extract: 4%, Pachyphyllum yunnanensis extract: 0.5%, stearyl alcohol: 5%, caprylic acid / capric triglyceride: 3%, cetearyl alcohol : 3%; Squalane: 4%, Glyceryl Tri(Ethylhexanoate): 3%, Dimethicone: 0.5%, Disodium EDTA: 0.1%, Carbomer: 1%, Sodium Hyaluronate: 0.05%, 1,3-Propanediol: 5%, Glycerin: 4%, L-Arginine: 0.5%, Allantoin: 0.3%, Dipotassium Glycyrrhizinate: 0.1%, to Ionized water makes up the balance; the sum of the above components is 100%;

[0065] (2) Put sodium hyaluronate, 1,3-propanediol and glycerin in the emulsification pot, start stirring at a speed of 35-45r / min, then add water with 50% of the total composition into the emulsification pot, and put the carbomer Sprinkle slowly into the...

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Abstract

The invention discloses a skin care product which contains a periplaneta americana extract and is suitable for skins of diabetic patients, and belongs to the technical field of cosmetics. Effective ingredients of the protective skin care product disclosed by the invention can be the periplaneta americana extract, a rhizoma paridis yunnanensis extract and daily cosmetics, and auxiliaries used in the skin care product. The periplaneta americana and rhizoma paridis yunnanensis raw materials as the effective ingredients of the skin care product disclosed by the invention can be used as the effective ingredients for keeping beauty and moistening skin, so that the skin care effect for the diabetic patients is obvious, particularly due to addition of the rhizoma paridis yunnanensis extract as theeffective ingredient, under a synergistic effect of the periplaneta americana extract and a matrix, the transdermal absorptivity is higher, the antibacterial effect is higher, the skin repairing effect is better, the product has a good curative effect on skin-pigmented depressed scars for the diabetic patients, alone application or excessive application of the periplaneta americana the side effect of wound scars of the skin are alleviated to a great extent, and the product has good application prospects.

Description

technical field [0001] The invention discloses a cosmetic used for skin care of diabetic patients, in particular to a skin care product containing Periplaneta americana extract suitable for the skin of diabetic patients, and belongs to the technical field of cosmetics. Background technique [0002] According to the latest data released by the International Diabetes Federation, the number of diabetic patients worldwide has reached 425 million, and it is estimated that by 2045, the number of diabetic patients may reach 629 million. The number of diabetic patients in China is about 114.4 million, which has become the country with the largest number of patients. The World Health Organization has listed "diabetes" as one of the three difficult diseases, and its prevention and treatment has become one of the key and hot areas of global medical research. As one of the most common complications of diabetes, diabetic dermatopathy occurs in various stages of diabetes and can damage t...

Claims

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Application Information

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IPC IPC(8): A61K8/98A61K8/9794A61Q19/00A61Q19/02A61Q17/00A61P3/10A61P17/02
CPCA61K8/987A61K8/9794A61Q19/00A61Q19/02A61Q17/005A61P3/10A61P17/02A61K2800/5922
Inventor 陆地吕乐春陈真韩毅桂莉
Owner KUNMING MEDICAL UNIVERSITY
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