Method to generate biocompatible dendritic polymers for analyte detection with multimodal labeling and signal amplification

A technology for polymers and analytes, used in biochemical equipment and methods, determination/inspection of microorganisms, analytical materials, etc.
CN110799576AActive Publication Date: 2020-02-14UNIV OF SOUTHERN CALIFORNIA
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
UNIV OF SOUTHERN CALIFORNIA
Publication Date
2020-02-14

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Abstract

Described herein is a method to create dendritic biocompatible polymers from pairs of complementary dendritic nucleic acid monomers in a controlled manner, using polymerization triggers. The dendriticmonomers are constituted of nucleic acids and an organic polymer capable of self-assembly. Each polymer contains approximately 200 dendrites that can be used to attach labels and constitute a biologically compatible signal amplification technology. Depending on the context this technology could be used to reveal the presence of a large variety of analytes such as specific nucleic acid molecules,small molecules, proteins, and peptides.
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Description

[0001] Statement Regarding Federally Sponsored Research or Development

[0002] This invention was made with government support under Award HD075605 from the National Institutes of Health. The government has certain rights in this invention. technical field

[0003] Described herein are methods and compositions related to dendrimers for labeling and detecting analytes. Background technique

[0004] Innovative protocols are needed to detect analytes of interest in complex mixtures. Most analytes have no inherent signal to be used as a detection label. Therefore, new technologies are urgently needed to label analytes with easily detectable labels such as chromogens or fluorophores. In addition, techniques capable of signal amplification are often preferred over direct labeling methods because they enhance the signal-to-noise ratio, which increases ease and accuracy of detection. Furthermore, the most appropriate label to employ may vary in a particular case and may depend,...

Claims

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