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A mofs-modified double-layer structure composite electrospun nanofiber membrane and its preparation method and its application in blood purification

A technology of electrospinning nanofibers and a double-layer structure, which is applied in fiber processing, electrospinning, chemical instruments and methods, etc., can solve the problems of complex preparation process, lack of creatinine clearance, lack of creatinine clearance, etc., and achieve simple operation and improved The effect of quality of life, good application prospects

Active Publication Date: 2022-02-25
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The publication number is CN110026098A, which introduces chitosan hemodialysis membrane, the dialysis membrane prepared by it can reach 87.1% to urea clearance rate, and can reach 96.7% to protein retention rate, but its preparation process is comparatively complicated, and lacks the creatinine clearance
In the Chinese invention patent with the publication number CN105709613A, a nanofiber composite membrane for removing medium biomolecules is introduced. The composite membrane prepared by the composite membrane has a removal rate of 80-90% for urea and a retention rate of 98.5-9.5% for protein. %, lack of clearance of creatinine

Method used

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  • A mofs-modified double-layer structure composite electrospun nanofiber membrane and its preparation method and its application in blood purification
  • A mofs-modified double-layer structure composite electrospun nanofiber membrane and its preparation method and its application in blood purification
  • A mofs-modified double-layer structure composite electrospun nanofiber membrane and its preparation method and its application in blood purification

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Dissolving polyacrylonitrile in the solvent N,N-dimethylformamide, wherein the mass fraction of polyacrylonitrile is 10wt%, heating and stirring at 50°C until it is completely dissolved; after the solution is completely dissolved, a spinning solution is obtained, and the Spinning liquid is carried out electrospinning; In 100mL pH is the tris (hydroxymethyl) aminomethane hydrochloride buffer solution of 8.5, add 200mg dopamine, put into the buffer solution after the electrospun nanofiber obtained is infiltrated by ethanol, Heated and stirred at 45°C for 24h, washed with distilled water and dried overnight in a drying oven at 60°C; soaked the obtained nanofibrous membrane in 24mL of 0.5M water and ethanol (the volume ratio of water and ethanol was 1:1 ) as a solvent of copper nitrate solution, ultrasonic 10min, and after stirring at room temperature for 1h, add 24mL of 0.25M trimesic acid solution with water and ethanol (the volume ratio of water and ethanol is 1:1) as sol...

Embodiment 2

[0042] Dissolve polyacrylonitrile in the solvent N,N-dimethylformamide, wherein the mass fraction of polyacrylonitrile is 8.5wt%, and heat and stir at room temperature until it is completely dissolved; after the solution is completely dissolved, a spinning solution is obtained, and the Spinning liquid is carried out electrospinning; In 80mL pH is the tris (hydroxymethyl) amino methane hydrochloride buffer solution of 8.5, add 160mg dopamine, put into the buffer solution after the electrospun nanofiber obtained is infiltrated by ethanol, Heat and stir at 45°C for 24h, wash with distilled water and dry overnight in a 60°C drying oven; soak the obtained nanofibrous membrane in 48mL of 0.8M copper nitrate ethanol solution, sonicate for 10min, and stir at room temperature for 1h Finally, add 48mL of 0.4M trimesic acid ethanol solution, and slowly stir the reaction at 50°C for 2h; after the reaction is completed, wash the nanofibrous membrane with ethanol and dry it in an oven at 60°...

Embodiment 3

[0045] Dissolving polyacrylonitrile in the solvent N,N-dimethylformamide, wherein the mass fraction of polyacrylonitrile is 9wt%, heated and stirred at 70°C until completely dissolved; after the solution was completely dissolved, a spinning solution was obtained, and Spinning liquid is carried out electrospinning; In 100mL pH is the tris (hydroxymethyl) aminomethane hydrochloride buffer solution of 8.5, add 200mg dopamine, put into the buffer solution after the electrospun nanofiber obtained is infiltrated by ethanol, Heat and stir at 45°C for 24h, wash with distilled water and dry in a 60°C drying oven overnight; soak the obtained nanofibrous membrane in 30mL of 0.7M copper nitrate solution, sonicate for 10min, and stir at room temperature for 1h , add 30mL 0.35M ethanol solution of trimesic acid, and carry out hydrothermal reaction at 110°C for 5h; after the reaction is completed, wash the nanofibrous membrane with water and ethanol and dry it in an oven at 60°C overnight to ...

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Abstract

The invention relates to a preparation method of a MOFs-modified double-layer structure composite electrospun nanofiber membrane and its application in blood purification. The upper layer of the composite nanodialysis membrane is chitosan / sericin composite electrospun nanofiber membrane, The lower layer is polyacrylonitrile nanofiber membrane modified by MOFs. The functionalized nanofiber dialysis membrane is prepared by combining electrospinning technology and hydrothermal method. The lower layer is made of polyacrylonitrile as the matrix, and the surface is wrapped with polydopamine to improve its hydrophilicity, so that the outermost layer grows Cu 3 (BTC) 2 Crystal particles; the upper layer is chitosan / sericin composite nanofiber membrane. The MOFs-modified double-layer structure composite electrospun nanofiber membrane obtained in the invention can effectively remove urea and creatinine, and has an excellent simulated hemodialysis effect. The preparation process of the invention is simple and easy, the raw materials are easy to obtain, the cost is low, and the invention has good application prospects.

Description

technical field [0001] The invention belongs to the technical field of environmental nano-new functional materials, and in particular relates to a MOFs-modified double-layer structure composite electrospun nanofiber membrane, a preparation method thereof and its application in blood purification. Background technique [0002] With the continuous aggravation of the aging process of our society, the high incidence of diseases such as hypertension and hyperglycemia leads to a continuous increase in the incidence of renal failure. According to statistics, the incidence of chronic kidney disease in my country is as high as 11%, and it is increasing year by year; different from European and American countries, glomerulonephritis is currently the main cause of uremia in China, but chronic renal failure caused by diabetes and hypertension. The number of patients continues to increase and gradually becomes the mainstream. [0003] Hemodialysis (HD) is one of the renal replacement the...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01D71/42B01D67/00B01D69/12B01D69/02D04H1/728D04H1/43D01D5/00A61M1/16
CPCB01D71/42B01D67/0002B01D69/12B01D69/02D04H1/728D04H1/43D01D5/003A61M1/1621B01D2325/36
Inventor 李响晁珅
Owner JILIN UNIV
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