Preparation method of m-trifluoromethylphenol

Abstract

The invention discloses a preparation method of m-trifluoromethylphenol. The preparation method of the m-trifluoromethylphenol comprises the steps that (1) in a continuous flow reactor, a sulfate aqueous solution and an aqueous solution of sodium nitrite are subjected to a diazotization reaction to obtain a diazonium salt solution, wherein the sulfate aqueous solution is a mixture of an aqueous solution of sulfuric acid and m-trifluoromethyl aniline; and (2) in the continuous flow reactor, under the existence of an aromatic solvent, the diazonium salt solution obtained in the step (1) is subjected to a hydrolysis reaction to obtain the m-trifluoromethylphenol, wherein the temperature of the hydrolysis reaction is 101-200 DEG C. Through the continuous preparation method, the reaction concentration can be increased, the reaction time can be greatly shortened, production efficiency is improved, the safety risk is lowered, the yield can reach 95% or above, the purity can reach 99.5% or above, and the method has the advantages of being easy and convenient to operate, safer, more environmentally friendly, lower in cost and the like.

Description

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AI Technical Summary

Benefits of technology

This patented process helps improve the production of high-purity products from trifluronanone that has potential uses such as pesticides or pharmaceuticals. It also enhances heat transfer during chemical reformation processes while reducing excessive amounts of wastes produced due to poor solubility issues associated with impure starting materials used in these methods. Additionally, this technology allows for efficient separation of unwanted side product compounds without causing problems like blockages downstream equipment. Overall, this new approach saves on energy usage and costs compared to existing techniques.

Problems solved by technology

Technological Problem addressed in this patents relating to improving the quality of crude triazole obtained through various techniques involves efficiently producing these valuable substances without generating harmful waste streams due to its use in drug manufacturing. Additionally, current methods have limitations in terms of controllability, speediness, sensitivity, and output stability when applied to different types of substrate.

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