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Personalized cancer medication database system and establishment method

A technology for establishing methods and databases, which is applied in the field of information processing of anticancer drugs, can solve the problems of huge consumption of manpower and material resources, no tumor suppressing effect, and long experiment cycle, and achieve the effect of precise treatment

Active Publication Date: 2020-02-25
WUHAN UNIV
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Problems solved by technology

[0007] Nowadays, for cancer treatment, the individual differences in the efficacy of anticancer drugs are very large. Some patients even take anticancer drugs but have no tumor suppressing effect at all. possible reasons for the differences
[0008] Difficulty in solving the above technical problems: It is necessary to input the data and curves of the influence of estrogen on various anti-cancer drugs in the database, but there are many anti-cancer drugs and the long experiment cycle leads to a huge consumption of manpower and material resources

Method used

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  • Personalized cancer medication database system and establishment method
  • Personalized cancer medication database system and establishment method
  • Personalized cancer medication database system and establishment method

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Embodiment

[0046] Tamoxifen, used to treat advanced breast and ovarian cancer. In the clinical treatment of breast cancer, the effective rate is generally 30%. Estrogen receptor positive patients have better curative effect (49%), and negative patients have poor curative effect (7%). Both premenopausal and postmenopausal patients can be used, and postmenopausal and people over 60 years of age are more effective than premenopausal and younger patients. In terms of lesion sites, skin, lymph nodes, and soft tissues have good curative effects, while bone and visceral metastases are less effective.

[0047] Tamoxifen is a synthetic anti-estrogen drug. Similar in structure to estrogen, it can compete with estradiol for estrogen receptors, form a stable complex with estrogen receptors, and transport into the nucleus to prevent the opening of chromosomal genes, thereby inhibiting the growth and development of cancer cells.

[0048] Estrogen receptors are distributed in bones, breasts, central ...

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Abstract

The invention belongs to the technical field of anti-cancer drug information processing, and discloses a personalized cancer medication database system and an establishment method. The method comprises steps of establishing a cancer type and a cancer staging database; recording data of various cancer drugs, and recording input graphs or curves of data intervening in cancer growth along with estrogen concentration change into the database; marking different types of data with significant differences; and selecting an input mode I and an input mode II to analyze a data result of cancer drug intervention cancer growth. The system comprises a customization module for recording data of growth intervention by various cancer drugs according to tumor tissues or cancer cell samples of a patient. Byutilizing the influence of the estrogen level on the effectiveness of the anti-cancer drug, the anti-cancer drug with the maximum curative effect under the estrogen level of a patient is helped to beselected, the maximum curative effect of the anti-cancer drug on various tumors including breast cancer is assisted, and accurate treatment of the anti-cancer drug on the various tumors including breast cancer is achieved.

Description

technical field [0001] The invention belongs to the technical field of anticancer drug information processing, and in particular relates to a personalized cancer drug database system and a method for establishing it. Background technique [0002] Currently, the closest prior art: [0003] Estrogen is an octadecyl-carbon steroid hormone secreted by the ovary, testis, placenta or adrenal cortex of vertebrates. The main endogenous estrogen in most mammals is 17β-estradiol (17β-estradiol, E2). Estrogen can promote cell division and proliferation, stimulating potential tumor growth. The occurrence of cancer is related to the level of estrogen in the body. Breast cancer, uterine fibroids, ovarian cancer, prostate cancer, etc. are closely related to the abnormality of estrogen signaling pathway. An important protein in the estrogen signaling pathway is estrogen receptor (ER), which is distributed in bones, breasts, central nervous system, cardiovascular and cerebrovascular syst...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G16H70/40
CPCG16H70/40
Inventor 项瑾戚苗苗王昕
Owner WUHAN UNIV
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