A personalized cancer medication database system and its establishment method
A technology for establishing methods and databases, which is applied in the field of information processing of anticancer drugs, can solve the problems of huge consumption of manpower and material resources, long experiment cycle, and no tumor suppressing effect, so as to achieve the effect of realizing treatment and realizing precision
Active Publication Date: 2022-07-12
WUHAN UNIV
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Problems solved by technology
[0007] Nowadays, for cancer treatment, the individual differences in the efficacy of anticancer drugs are very large. Some patients even take anticancer drugs but have no tumor suppressing effect at all. possible reasons for the differences
[0008] Difficulty in solving the above technical problems: It is necessary to input the data and curves of the influence of estrogen on various anti-cancer drugs in the database, but there are many anti-cancer drugs and the long experiment cycle leads to a huge consumption of manpower and material resources
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[0046] Tamoxifen, used to treat advanced breast and ovarian cancer. In clinical treatment of breast cancer, the effective rate is generally 30%. The efficacy of estrogen receptor-positive patients is better (49%), and the efficacy of negative patients is poor (7%). It can be used by both premenopausal and postmenopausal patients, while postmenopausal and over 60-year-olds are more effective than premenopausal and younger patients. From the point of view of the lesion site, the skin, lymph nodes and soft tissue have a good effect, and the bone and visceral metastasis have a poor effect.
[0047] Tamoxifen is a synthetic antiestrogen drug. Similar in structure to estrogen, it can compete with estradiol for estrogen receptors, form stable complexes with estrogen receptors, and transport them into the nucleus, preventing the opening of chromosomal genes, thereby inhibiting the growth and development of cancer cells.
[0048] Estrogen receptors are distributed in bones, breast, c...
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The invention belongs to the technical field of anticancer drug information processing, and discloses a personalized cancer drug database system and a method for establishing the database, establishing a database of cancer types and cancer stages, inputting data of various cancer drugs, and data of intervening tumor growth. The graph or curve with the change of estrogen concentration is entered into the database; the data with significant differences are marked with different types; the input method 1 and method 2 are selected to analyze the data results of cancer drug intervention on tumor growth. The present invention includes a customized module, according to the patient's tumor tissue or cancer cell samples, input data of multiple cancer drugs intervening in its growth; the present invention utilizes the effect of estrogen levels on the effectiveness of anticancer drugs to help select estrogen in patients The most effective anticancer drug at the level, and the auxiliary anticancer drug maximizes the efficacy of various tumors including breast cancer, and realizes the precise treatment of anticancer drugs for various tumors including breast cancer.
Description
technical field [0001] The invention belongs to the technical field of anticancer drug information processing, and in particular relates to a personalized cancer drug database system and a method for establishing the same. Background technique [0002] Currently, the closest existing technology: [0003] Estrogen is an 18-carbon steroid hormone secreted by the ovary, testis, placenta or adrenal cortex of vertebrates. The major endogenous estrogen in most mammals is 17β-estradiol (17β-estradiol, E2). Estrogen promotes cell division and proliferation, stimulating potential tumor growth. The occurrence of cancer is related to the level of estrogen in the body. Breast cancer, uterine fibroids, ovarian cancer, and prostate cancer are closely related to the abnormality of estrogen signaling pathway. An important protein in the estrogen signaling pathway is estrogen receptor (ER), which is distributed in bones, breasts, central nervous system, cardiovascular and cerebrovascular...
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IPC IPC(8): G16H70/40
CPCG16H70/40
Inventor 项瑾戚苗苗王昕
Owner WUHAN UNIV