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Device and method for extracting Radix Salviae Miltiorrhizae extract

An extraction method and technology of an extraction device, which are applied in the field of extraction devices of Salvia miltiorrhiza extracts, can solve the problems of inability to extract effective components, poor pulverization effect, and poor quality of medicines, achieve reasonable design and high efficiency, reduce waste of resources, The effect of ethanol consumption reduction

Inactive Publication Date: 2020-02-28
武玲
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Due to the obvious medicinal value of Danshen, the extraction of active ingredients in Danshen is more and more worthy of attention. Generally, the simple water decoction extraction or alcohol extraction used in experiments cannot completely extract the effective components of Danshen. The ingredients are extracted, and the two methods are combined, and the specific processing technology is selected by the ethanol reflux-water decoction method, and the water-soluble and fat-soluble ingredients can be extracted at the same time, but the consumption cost is relatively high.
[0006] The pulverizer is a machine that crushes large-sized solid raw materials to the required size. The pulverizer is composed of devices such as coarse crushing, fine crushing, and wind conveying. It achieves the purpose of the pulverizer in the form of high-speed impact. The screening procedure is mainly used in various industries such as mines, building materials and medicine, but the existing drug grinder can only be crushed once, and the crushing effect is poor, resulting in poor quality of the produced drugs

Method used

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  • Device and method for extracting Radix Salviae Miltiorrhizae extract
  • Device and method for extracting Radix Salviae Miltiorrhizae extract
  • Device and method for extracting Radix Salviae Miltiorrhizae extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] A method for extracting salvia miltiorrhiza extract, comprising the steps of:

[0050]S1. Clean the fresh salvia miltiorrhiza with tap water, transfer it to the shade to dry, crush the dried salvia miltiorrhiza with a small grinder, and continue to ultrafinely pulverize the crushed salvia miltiorrhiza to 1000-3000 To remove miscellaneous roots and uncrushed particles;

[0051] S2, take the ultrafinely pulverized Salvia miltiorrhiza sample and put it into a conical flask, add tap water, the range of the solid-to-liquid ratio of Salvia miltiorrhiza and tap water is 1:15-1:20, adjust the pH to acidity with hydrochloric acid solution, the pH value The range is 3-5;

[0052] S3, add compound enzyme in acidic solution, compound enzyme is made up of cellulase and pectinase, and cellulase: pectinase=2:1, the addition amount of compound enzyme is 1.5%-2.0%, with plastic wrap Seal the film, put the Erlenmeyer flask into a temperature-controlled ultrasonic cleaner, conduct ultra...

Embodiment 2

[0056] On the basis of Example 1, taking the determination of salvia miltiorrhiza acid B and tanshinone IIA in the salvia miltiorrhiza extract as an example, the dried salvia miltiorrhiza was pulverized by a small pulverizer and then ultrafinely pulverized for 10 minutes to 1000-3000 mesh to remove miscellaneous roots and Without pulverizing the particles, accurately weigh 3.0g of superfine Danshen powder, place Salvia miltiorrhiza in a 50mL conical flask, add an appropriate amount of tap water, the solid-liquid ratio is 1:20, the amount of compound enzyme added is 1.5%, and 0.2mol / LHCl solution to adjust the pH to 3, ultrasonically treat at 45°C for 20min, collect the filtrate after filtration, and combine figure 2 , through the average value of three determinations, the content of salvianolic acid B in the medicine is 4.05%, the relative standard deviation of three determinations is 2.87%, the test conditions are good, and the total extraction rate is 78.02%.

[0057] Add ...

Embodiment 3

[0060] On the basis of Example 2, 10-15 times the amount of tap water was added to the Danshen extract extracted by S4 and S5, and refluxed for 2-3 times, each extraction time was 1.5-2h, combined and filtered after extraction, to obtain Danshen Water Extract.

[0061] The viscosity of Danshen water extract satisfies: η=aC b ,and Among them, A, a, and b are all constants, C is the concentration of the salvia miltiorrhiza in water extract, and the unit is Brix, and ρ is the density, and the unit is Kg / m 3 , Re is the Reynolds quasi-number.

[0062] The relationship between ultrasonic extraction temperature T and viscosity satisfies: Among them, A and B are constants.

[0063] The extraction temperature, concentration and viscosity of the salvia miltiorrhiza water extract meet: Among them, c, d, E a , f are constants.

[0064] On the basis of physical property data and according to the specific equipment size, several important investigation parameters of Danshen extra...

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Abstract

The invention relates to a method for extracting Radix Salviae Miltiorrhizae extract, which comprises the steps of: S1, crushing fresh Radix Salviae Miltiorrhizae; S2, adding a Radix Salviae Miltiorrhizae sample into a conical flask, adding tap water, adjusting PH with hydrochloric acid solution; S3, adding a compound enzyme, cooling the conical flask after ultrasonic treatment, and filtering to obtain a supernatant; S4, adding an ethanol solution into filter residue, carrying out ultrasonic treatment, and collecting filtrate after solid-liquid separation; S5, allowing the primary extract to stand, centrifuging, and carrying out ultrafiltration on the centrifuged solution by means of an ultrafiltration membrane to obtain Radix Salviae Miltiorrhizae extract. The method provided by the invention helps reduce the extraction cost and improve the extraction efficiency. The invention also provides an extraction device, which comprises a first processing chamber and a second processing chamber; the first processing chamber is provided with a spiral stirrer and a first motor, and the second processing chamber is symmetrically provided with two crushing rollers and a second motor. The extraction device avoids the fact that crushing efficiency is affected since a crusher is stopped due to too much load.

Description

technical field [0001] The invention belongs to the technical field of pharmacy, and in particular relates to an extraction device and method of salvia miltiorrhiza extract. Background technique [0002] Salvia miltiorrhiza belongs to the herbaceous plant of the genus Salvia in the family Lamiaceae. The color of the root part of the plant is mostly red, and the shape is similar to ginseng, so it is named: "Danshen". As a traditional Chinese medicinal plant, the main medicinal part is the dry root and its tuber. It has the effects of relaxing tendons and promoting blood circulation, clearing the heart and avoiding heat, antibacterial and anti-inflammatory, cooling blood and eliminating carbuncle. It can be widely used in the treatment of arterial diseases, coronary heart disease, high blood pressure Blood pressure, angina, myocardial ischemia, liver cirrhosis and other symptoms. [0003] The active components of Danshen are mainly tanshinone compounds in fat-soluble componen...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/537B01D11/02B02C18/08
CPCA61K36/537A61K2236/13A61K2236/15A61K2236/19A61K2236/331A61K2236/333A61K2236/53B01D11/02B02C18/08
Inventor 武玲
Owner 武玲
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