Method for rapidly calibrating Raman spectrometer by using acetaminophen

Abstract

The invention provides a method for rapidly calibrating a Raman spectrometer by using acetaminophen. The method comprises the steps of acquiring the spectrum of an acetaminophen standard substance byusing the Raman spectrometer to obtain n characteristic peak positions; obtaining a spectral peak position difference delta Xn=Xn-Yn of each characteristic peak, and calculating an average error deltaX average=(delta X1+delta X2+delta X3 +..., delta Xn) / n; calculating the difference value of the spectral peak positions of every two continuous measurement characteristic peaks according to the equation that L(n-1)n= Xn-Xn-1 to obtain the interval between the spectral peak positions of the two characteristic peaks; performing difference calculation on every two continuous standard spectrum peakpositions to obtain an interval between the two standard spectrum peak positions, wherein S(n-1)n= Yn-Yn-1; calculating the average deviation coefficient A average; and modifying the Raman spectrum measurement result when the delta X average is not equal to 0, and Zn is equal to A average*Zn+delta X average after being modified.

Description

technical field [0001] The invention relates to rapid calibration of a Raman spectrometer at 200-3400 wavenumbers by using acetaminophen standard substance, and realizes calibrating the spectrum of the Raman spectrometer by collecting paracetamol spectral data. Background technique [0002] The Raman spectrometer is an instrument that receives the Raman scattering spectrum. Raman scattering is an inherent characteristic of the molecules that make up the substance. Therefore, the analysis of the molecular structure of the substance can be realized by reading the Raman scattering spectrum of a certain substance. For this, the spectrometer cone The ability to accurately identify each characteristic peak in the spectrum of a substance is particularly important. Therefore, it is obviously necessary to quickly calibrate the spectrum of the Raman spectrometer before use. [0003] At present, there are two commonly used spectral calibration methods for Raman spectrometers; one is to...

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Problems solved by technology

[0004] Using the stable properties of single crystal silicon in a fixed form in nature, the obtained Raman spectrum is used to calibrate the Raman spectrometer. The advantage is that it is fast and simple. The disadvantage is that single crystal silicon only has a characteristic peak at 520cm-1, which cannot be realized at a distance of 520cm The spectrum at -1 is accurately calibrated, so the ability to correct the deviation of the Raman spectrum in the long-wavelength range is weak. The second method uses the natural frequency and fixed wavelength of the atomic spectral line. The advantage is that it can correct the overall long-spectrum For calibration, the disadvantage is that you need to carry a low-voltage atomic spectrum lamp, which is not conducive to the rapid on-site calibration of miniaturized instruments and portable instruments

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