Unlock instant, AI-driven research and patent intelligence for your innovation.
Rare earth complexes constructed based on 2-methyl-5, 7-dichloro-8-hydroxyquinoline as well as preparation method and applications of rare earth complexes
What is Al technical title?
Al technical title is built by PatSnap Al team. It summarizes the technical point description of the patent document.
A rare earth complex, hydroxyquinoline technology, applied in medical preparations containing active ingredients, pharmaceutical formulations, organic chemical methods, etc., can solve the problem of no anti-proliferative activity, and achieve the effect of low liver cell toxicity
Inactive Publication Date: 2020-03-13
GUANGXI NORMAL UNIV
View PDF5 Cites 3 Cited by
Summary
Abstract
Description
Claims
Application Information
AI Technical Summary
This helps you quickly interpret patents by identifying the three key elements:
Problems solved by technology
Method used
Benefits of technology
Problems solved by technology
Existing experiments have shown that 2-methyl-5,7-dichloro-8-hydroxyquinoline has no antiproliferative activity on various tumor cells (IC 50 >50uM), so far there is no evidence that 2-methyl-5,7-dichloro-8-hydroxyquinoline is used as a ligand to construct the lanthanidemetalerbium and holmium so that the resulting complex has significant tumor inhibitory activity. to report
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more
Image
Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
Click on the blue label to locate the original text in one second.
Reading with bidirectional positioning of images and text.
[0026] 45mg (0.2mmol) ligand H-ClQ and 46mg (0.1mmol) Er (NO 3 ) 3 ·6H 2 Add O to a Pyrex tube with one end closed and about 18 cm long, add 1.25 mL of a mixed solvent composed of ethyl acetate and water (the volume ratio of ethyl acetate and water is 4:1), add 2 drops of Et 3 N (the pH value of the system after stirring evenly is 8.0), vacuumize the Pyrex tube, and seal the other end. Put the sealed Pyrex tube into an oven at 80°C, react for 72 hours, and slowly cool down to room temperature. Yellow strip crystals can be observed at the bottom of the Pyrex tube. Collect the crystals and dry them. The yield was 67.9% (as Er(NO 3 ) 3 ·6H 2 O calculation).
[0027] The product obtained in this embodiment is characterized:
[0028] 1) Elemental analysis (%) (C 30 h 20 Cl 6 ErN 3 o 4 ), experimental value: C, 41.43, H, 2.43, N, 4.80; theoretical value: C, 41.58, H, 2.33, N, 4.85.
[0029...
Embodiment 2
[0048] Embodiment 2: the preparation of complex 1
[0049] Repeat Example 1, the difference is: change the volume ratio of ethyl acetate and water in the mixed solvent to 3:1, use Et 3 N adjusted the pH of the system to 7.7, changed the reaction to 60° C., and the reaction time was 80 h.
[0050] As a result, yellow stripy crystals were obtained. Yield 62% (based on Er(NO 3 ) 3 ·6H 2 O).
[0051] Elemental analysis, infrared analysis and X-raydiffraction analysis were carried out on the product obtained in this example, and it was confirmed that the obtained yellow strip crystal was the target product complex 1.
Embodiment 3
[0052] Embodiment 3: the preparation of complex 1
[0053] Repeat Example 1, the difference is: change the volume ratio of ethyl acetate and water in the mixed solvent to 5:1, use Et 3 N adjusted the pH of the system to 8.2, changed the reaction to 100° C., and the reaction time was 36 hours.
[0054] As a result, yellow stripy crystals were obtained. Yield 65% (based on Er(NO 3 ) 3 ·6H 2 O).
[0055] Elemental analysis, infrared analysis and X-raydiffraction analysis were carried out on the product obtained in this example, and it was confirmed that the obtained yellow strip crystal was the target product complex 1.
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More
PUM
Login to View More
Abstract
The invention discloses two rare earth complexes constructed on the basis of 2-methyl-5, 7-dichloro-8-hydroxyquinoline as well as a preparation method and application of the rare earth complexes. Thetwo rare earth complexes are respectively marked as complex 1 and complex 2, the molecular formula of the complex 1 is [Er(ClQ)3(H2O)], the molecular formula of the complex 2 is [Ho(ClQ)3(H2O)], and ClQ is 2-methyl-5, 7-dichloro-8-hydroxyquinoline with hydroxyl hydrogen atoms removed and with a unit of negative charges. The preparation method of the rare earth complexes comprises the following steps: taking 2-methyl-5, 7-dichloro-8-hydroxyquinoline and erbiumnitrate hexahydrate or holmiumnitrate hexahydrate, dissolving with a mixed solvent, and reacting under the heating conditions at a pH value of 7.7-8.2, thereby obtaining the rare earth complexes. Test results of the applicant show that the two rare earth complexes have a remarkable anti-proliferation effect on various tumor cells, are low in toxicity to human normal hepatocytes, and are expected to be developed into anti-tumor drugs.
Description
technical field [0001] The invention relates to a rare earth complex, in particular to a rare earth complex constructed on the basis of 2-methyl-5,7-dichloro-8-hydroxyquinoline and a preparation method and application thereof. Background technique [0002] At present, tumor seems to be the second leading disease of human death, which seriously endangers the physical and mental health of the people. Common malignant tumors include lungcancer, cervical cancer, breast cancer, liver cancer, lymphoma, leukemia and other types. Clinically, platinum-based antineoplastic drugs are still one of the most important chemotherapeutic drugs for tumor treatment, accounting for more than 50% of clinical chemotherapeutic drug applications. The main target of this type of drug against cancer is double-stranded DNA, and the main mechanism of action is to interfere with the double-strand replication of DNA in tumor cells, thereby exerting the goal of restraining cell growth. Despite their si...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More
Application Information
Patent Timeline
Application Date:The date an application was filed.
Publication Date:The date a patent or application was officially published.
First Publication Date:The earliest publication date of a patent with the same application number.
Issue Date:Publication date of the patent grant document.
PCT Entry Date:The Entry date of PCT National Phase.
Estimated Expiry Date:The statutory expiry date of a patent right according to the Patent Law, and it is the longest term of protection that the patent right can achieve without the termination of the patent right due to other reasons(Term extension factor has been taken into account ).
Invalid Date:Actual expiry date is based on effective date or publication date of legal transaction data of invalid patent.
Login to View More 
Login to View More