Rutundic acid R as leptin sensitizer as well as application thereof in preparation of weight-reducing medicines

A technology for weight loss of iron iodic acid, applied in the preparation of weight loss medicines, in the field of iron leptin sensitizer, can solve the problems such as no report on weight loss effect, so as to improve sensitivity and promote fat browning , the effect of reducing body fat

Inactive Publication Date: 2020-03-17
PEKING UNIV
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  • Abstract
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  • Application Information

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Problems solved by technology

At present, it has been found that ferric hollylic acid has the effect of anti-b...

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  • Rutundic acid R as leptin sensitizer as well as application thereof in preparation of weight-reducing medicines
  • Rutundic acid R as leptin sensitizer as well as application thereof in preparation of weight-reducing medicines
  • Rutundic acid R as leptin sensitizer as well as application thereof in preparation of weight-reducing medicines

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Embodiment Construction

[0017] The specific implementation manners of the present invention will be further described in detail below in conjunction with the accompanying drawings and embodiments. The following examples are used to illustrate the present invention, but are not intended to limit the scope of the present invention.

[0018] 57BL / 6J mice, male, 8 weeks old, 20-22 g, were purchased from Weitong Lihua Company.

[0019] Maintenance feed: purchased from the Department of Animals, Peking University Health Science Center

[0020] High Fat Feed: Buying with Boopac Corporation

[0021] db / db mice, male, 8 weeks old, 40-45 g, were purchased from the Department of Animals, Peking University Health Science Center.

[0022] Maintenance feed: purchased from the Department of Animals, Peking University Health Science Center

[0023] All animal experiments were strictly in accordance with the requirements of the "Guidelines for the Management and Use of Experimental Animals" and were approved by th...

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Abstract

The invention provides a rutundic acid R as a leptin sensitizer as well as application thereof in preparation of weight-reducing medicines. The in-vitro mechanism studies show that the rotundic acid Rcan significantly reduce the food intake of a mouse fed with high fat diet (HFD) so as to reduce the weight of the mouse; and the weight reduction effect on normal lean mice and mice lacking leptin receptors are weak. Besides, the body fat of the HFD-fed mouse can be reduced obviously by the rotundic acid R; and the fat browning and expression of fatty acid oxidation genes can be promoted by activating the mitochondrial function and the browning of subcutaneous white fat of the mouse is accelerated. The phosphorylation of downstream STAT3 is promoted by possibly inhibiting the activity of PTP1B, so that the sensitivity of a leptin receptor is improved and thus the effect of reducing weight is realized.

Description

technical field [0001] The invention belongs to the field of biology, and in particular relates to a ferric acid R leptin sensitizer and its application in the preparation of weight-loss drugs. Background technique [0002] As living standards improve, the prevalence of overweight and obesity is increasing at an alarming rate in both developed and developing countries around the world. Epidemiological studies have shown that overweight and obesity are important risk factors for diabetes, cardiovascular disease, cancer and premature death. The high prevalence of overweight and obesity and their attendant health risks make it a particularly relevant global public health challenge. Leptin, an adipocyte-derived hormone, is the primary messenger of information about peripheral energy stores to the central nervous system. At first, scientists wanted to inject exogenous leptin into obese patients to achieve the effect of suppressing appetite and losing weight, but they failed in ...

Claims

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Application Information

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IPC IPC(8): A61K31/56A61P3/04
CPCA61K31/56A61P3/04
Inventor 朱杰安永盼王昕谢正伟
Owner PEKING UNIV
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