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Saccharomyces cerevisiae DNA replication initial region identification method

A technology for Saccharomyces cerevisiae and region recognition, which is applied in the fields of biotechnology and genetic engineering, can solve the problems of low recognition accuracy, achieve fast recognition speed, and improve the effect of ORI recognition accuracy

Pending Publication Date: 2020-03-17
SHANDONG UNIV
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Problems solved by technology

[0007] This application provides a method for identifying the initiation region of Saccharomyces cerevisiae DNA replication to solve the problem of low identification accuracy

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  • Saccharomyces cerevisiae DNA replication initial region identification method
  • Saccharomyces cerevisiae DNA replication initial region identification method
  • Saccharomyces cerevisiae DNA replication initial region identification method

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Embodiment Construction

[0031] In order to enable those skilled in the art to better understand the technical solutions in the present application, the technical solutions in the embodiments of the present application will be clearly and completely described below in conjunction with the drawings in the embodiments of the present application. Obviously, the described The embodiments are only some of the embodiments of the present application, not all of them. Based on the embodiments in this application, all other embodiments obtained by persons of ordinary skill in the art without creative efforts shall fall within the scope of protection of this application.

[0032] see figure 1 , which is a structural schematic diagram of a method for identifying the initiation region of Saccharomyces cerevisiae DNA replication provided in the examples of this application, as shown in figure 1 As shown, the Saccharomyces cerevisiae DNA replication initiation region identification method provided in the embodimen...

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Abstract

The invention provides a saccharomyces cerevisiae DNA replication initial region identification method. The method comprises the following steps of: selecting a DNA sample from a saccharomyces cerevisiae gene sequence database; sliding on the DNA sample at equal step length by using a sliding window with the size of 3 to obtain a nucleotide triplet set; calculating the frequency of each nucleotidetriplet in the nucleotide triplet set; constructing the feature vectors of the DNA sample according to the frequency and the physicochemical properties of the nucleotide triplets; respectively inputting the feature vectors into a plurality of convolutional neural networks with different convolutional layer numbers, and selecting a target convolutional layer number according to the identificationeffect of the convolutional neural networks; performing hyper-parameter iteration on the convolutional neural networks with the target convolution layer number to obtain a target convolutional neuralnetwork with optimal hyper-parameters; and inputting a saccharomyces cerevisiae gene sequence to be detected into the target convolutional neural network to obtain a DNA replication initial region. According to the invention, the identification precision of the saccharomyces cerevisiae DNA replication initial region is improved.

Description

technical field [0001] The present application relates to the technical fields of biotechnology and genetic engineering, in particular to a method for identifying the DNA replication initiation region of Saccharomyces cerevisiae. Background technique [0002] DNA replication refers to the biological process in which DNA double strands perform semi-conservative replication with one DNA strand as the parent strand before cell division, producing two daughter strands that are the same as the original DNA strand. Revealing the process of cell replication is of great significance for a deeper understanding of gene information transmission. Many biological experiments have shown that DNA replication starts from a special gene location, which is called ORI (Origin of Replication, replication initiation region). How to identify the gene replication region is an important task in revealing the process of cell replication. [0003] In order to identify gene replication regions, there...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G16B20/00G06N3/04
CPCG16B20/00G06N3/045
Inventor 杨润涛吴峰张承进陈金桂张丽娜
Owner SHANDONG UNIV
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