Embolic microspheres

A technology of embolization and microenvironment, applied in catheters, surgery, coatings, etc., can solve problems such as reducing the rate of glycolysis, increasing hypoxic incompetence, and reducing the efficacy of TACE or TAE

Active Publication Date: 2020-03-17
VARIAN MEDICAL SYSTEMS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, tumor progression is known to lead to intratumoral lactic acidosis as a by-product of the Warburg effect and high levels of hypoxia
It has been hypothesized that TACE or TAE can increase hypoxia and the inability to flush lactic acid out of the tumor, and eventually localization of this high-level lactic acidosis reduces the rate of glycolysis, thereby reducing the rate of glycolysis by converting cancer cells into a dormant state, by making cells Stop in G0 / G1 phase and reduce the efficacy of TACE or TAE by reducing their dependence on glucose

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] The coating material of the pH adjusting agent is sprayed on the surface of the embolic microspheres to provide the microspheres with slow release of the pH adjusting agent. In a specific embodiment, diethanolamine is dissolved in isopropanol and sprayed on On the surface of the embolized microspheres, such that diethanolamine is present on the microspheres in an amount ranging from 10 wt% to 50 wt% based on the total weight of the coated microspheres. The microspheres can then be dried in a vacuum oven to remove excess solvent. If desired, such microspheres can be diluted with a suitable solution (for example, saline solution or contrast solution) to a dilution (volume) of 2-fold, 5-fold, 10-fold, 20-fold or more, or subsequently when administered to a patient Such microspheres can be diluted with a suitable solution (eg, saline solution or contrast solution).

Embodiment 2

[0060] In addition to adding an osmolarity agent, specifically dextrose, to the coating solution such that the osmolarity agent is present on the microspheres in an amount ranging from 0.001 wt % to 5 wt % based on the total weight of the coated microspheres, The remainder was formed into microparticles as described in Example 1.

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Abstract

In some aspects, the disclosure pertains to injectable particles that contain at least one pH-altering agent that is configured to be released from the injectable particles in vivo, upon embolizationof an intratumoral artery of a tumor with the injectable particles. In certain instances, the pH-altering agent may be a basic agent having a pH value of 7.5, a buffering agent having a pKa value of 7.6 or more, or both. Other aspects of the disclosure pertain to preloaded containers containing such injectable particles and methods of using such injectable particles.

Description

[0001] Cross References to Related Applications [0002] This application claims the benefit of U.S. Provisional Patent Application No. 62 / 531,956, entitled "Embolic Microspheres," filed July 13, 2017, the entire disclosure of which is incorporated herein by reference. Background technique [0003] Many clinical manifestations benefit from modulation of the vascular, lymphatic, or ductal systems by restricting the flow of bodily fluids or secretions. For example, the technique of embolization involves introducing microparticles into the circulation to occlude blood vessels, eg, to stop or prevent bleeding or to cut off blood flow to structures or organs as a means of restricting essential oxygen and nutrients from reaching target tissues. Permanent or temporary occlusion of blood vessels is desirable for the management of various diseases and conditions. [0004] In a typical embolization procedure, local anesthesia is first administered over the common artery. The artery i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/10A61K9/16
CPCA61K9/0019A61K9/1617A61K9/1623A61L2430/36A61L24/0015A61L24/0031A61L24/0042A61L24/02A61L24/043A61L24/046A61L24/06A61L2300/604A61L2300/608A61L2400/06A61L2420/06A61L2420/08A61M25/0097
Inventor 曾红霞布鲁斯·R·福赛思曹宏马修·R·德威特海蒂·施万兹
Owner VARIAN MEDICAL SYSTEMS
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