Application of 14,15-epoxyeicosatrienoic acid in preparing medicine for treating depression and/or anxiety

Abstract

The invention discloses an application of 14,15-epoxyeicosatrienoic acid (14,15-EET) in preparing a medicine for treating depression and / or anxiety. Experiments find that the total EET and 14,15-EET content of mPFC in a brain is positively correlated with an antidepressant behavior index (SI ratio), and confirm that when the 14,15-EET is increased in the brain, the antidepressant effect can be realized, and when the level of the 14,15-EET in plasma is raised, the antidepressant effect can be produced; and when an Ephx2 gene in a liver is specifically knocked out, the level of the 14,15-EET inthe plasma can be raised, and when Cre expression is induced, the formation of sEH multimers can be interfered, the activity of sEH enzymes can be reduced, and the level of the 14,15-EET in the plasmacan be raised. The 14,15-EET has important value for developing the novel and effective antidepressant.

Description

technical field [0001] The invention belongs to the field of medical biology, and specifically relates to the application of 14,15-epoxyeicosatrienoic acid in the preparation of drugs for treating depression and / or anxiety and / or early warning and clinical diagnosis of anxiety. Background technique [0002] Depression seriously endangers human life and health. Depression refers to a type of mood disorder syndrome characterized by low mood, slow thinking, accompanied by psychomotor retardation symptoms such as decreased interest and decreased initiative. The incidence rate is very high, and the lifetime prevalence rate is about 15-17%, and it has been increasing year by year in recent years; according to the World Health Organization, by 2020, depression will become the first cause of disability, and it is the 21st century. main killer. Depression has caused a huge burden on society, family and patients themselves, seriously endangering human life and health. Therefore, th...

AI Technical Summary

Problems solved by technology

The treatment of depression mainly relies on drug therapy; although there are many effective antidepressants clinically, they still cannot meet the needs of treatment

Especially the existing antidepressant ubiquitous serious problems: 1, onset is slow, generally just can improve clinical symptom after taking medicine 3-6 weeks, and will cure and need long-term medicine more; This is the main reason why the clinical effect of depression treatment is poor at present.

2. There are many side effects; 3. At least 35% of patients with depression do not respond to current drug treatment; 4. Expensive

EETs have four isomers, namely 5,6-EET, 8,9-EET, 11,12-EET and 14,15-EET; EETs have many similar biological activities, such as anti-inflammatory, anti-platelet aggregation , relax blood vessels, promote the growth of blood stem cell transplants, etc., but there are individual differences in tissue distribution and biological characteristics of the four isomers

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