Method for preparing Florfenicol soluble powder medicine

A technology of florfenicol and powder powder, which is applied in the field of veterinary drugs, can solve the problems of low absorption and bioavailability, limit the full effect of the drug, and low solubility of florfenicol, achieve remarkable curative effect, and the preparation method is simple and easy Line, reduce the effect of drug-resistant strains

Inactive Publication Date: 2020-03-27
临沂文一诺知识产权运营有限公司
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AI-Extracted Technical Summary

Problems solved by technology

[0003] Florfenicol has low solubility and is a water-insoluble powder, which affects the development of its soluble powder to a certain extent. Its absorption and bioavailability in animals are low, and it is often administered by mixing it into feed. The route of administration is s...
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Abstract

The invention discloses a method for preparing a Florfenicol soluble powder medicine, and relates to the technical field of veterinary medicines. The Florfenicol soluble powder medicine comprises thefollowing ingredients: Florfenicol, anhydrous citric acid, trimethoprim lactate, and anhydrous glucose. The preparation method of the Florfenicol soluble powder medicine disclosed by the invention comprises the following steps: weighing the Florfenicol, the anhydrous citric acid and the trimethoprim lactate, and carrying out crushing and sieving so as to obtain crushed materials; adding the anhydrous glucose, at an amount equal to the total weight of the three crushed materials, and carrying out premixing by adopting a dispersion means for 15 minutes so as to obtain a premix; and then, fully mixing the premix with the remaining anhydrous glucose for 1 hour so as to achieve uniform mixing, thereby obtain the Florfenicol soluble powder medicine. The Florfenicol soluble powder medicine prepared by the preparation method can be quickly dissolved with water so as to achieve the purpose of solubility; and moreover, the Florfenicol soluble powder medicine has the advantages of being convenient to administrate and capable of yielding faster results. In addition, the Florfenicol is adopted in combination with the synergists, so that overall treatment effects of the Florfenicol soluble powder medicine are enhanced, thereby having efficacy improved.

Application Domain

Antibacterial agentsOrganic active ingredients +1

Technology Topic

Trimethoprim LactateCitric acid +6

Image

  • Method for preparing Florfenicol soluble powder medicine

Examples

  • Experimental program(3)
  • Comparison scheme(1)
  • Effect test(1)

Example Embodiment

[0010] Example 1
[0011] A florfenicol soluble powder powder medicine, which is composed of 9 g of florfenicol, 9 g of anhydrous citric acid, 1.5 g of trimethoprim lactate, and anhydrous dextrose per 100 g of the medicine.
[0012] The method for preparing the above-mentioned florfenicol soluble powder powder medicine includes the following steps: after pulverizing florfenicol, anhydrous citric acid, and trimethoprim lactate, respectively, and then weighing 9g of florfenicol, anhydrous 9g of citric acid, 1.5g of trimethoprim lactate, 19.5g of anhydrous dextrose, premixed according to the dispersion method for 15 minutes, then added the remaining anhydrous dextrose to fully mix for 1 hour, and the embodiment of the invention is obtained after mixing. 1 Florfenicol soluble powder powder medicine.

Example Embodiment

[0013] Example 2
[0014] A florfenicol soluble powder powder medicine is composed of 10g florfenicol, 10g anhydrous citric acid, 2g trimethoprim lactate, and anhydrous glucose as the balance per 100g of the medicine.
[0015] The method for preparing the above-mentioned florfenicol soluble powder powder medicine includes the following steps: after smashing florfenicol, anhydrous citric acid, and trimethoprim lactate, respectively, after sieving, 10g of florfenicol, anhydrous 10g of citric acid, 2g of trimethoprim lactate, 22g of anhydrous dextrose, premixed according to the dispersion method for 15 minutes, then add the remaining anhydrous dextrose and mix thoroughly for 1 hour. After mixing, the fluorine in Example 2 of the present invention is obtained. Benicol soluble powder powder medicine.

Example Embodiment

[0016] Example 3
[0017] A florfenicol soluble powder powder medicine, which is composed of 11 g of florfenicol, 11 g of anhydrous citric acid, 2.5 g of trimethoprim lactate, and anhydrous dextrose per 100 g of the medicine.
[0018] The method for preparing the above-mentioned florfenicol soluble powder powder medicine includes the following steps: after smashing florfenicol, anhydrous citric acid, and trimethoprim lactate, respectively, sieving, 11g of florfenicol, anhydrous 11g of citric acid, 2.5g of trimethoprim lactate, 24.5g of anhydrous dextrose, premixed according to the dispersion method for 15 minutes, then added the remaining anhydrous dextrose and mixed thoroughly for 1 hour. After mixing, the embodiment of the invention is obtained. 3 Florfenicol soluble powder powder medicine.

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