Medical ultrasonic disinfection coupling agent and preparation method thereof

A couplant and ultrasonic technology, applied in the directions of disinfectants, botanical equipment and methods, and chemicals for biological control, etc., can solve the problems of adding a large amount of chemical fungicides, unable to achieve rapid sterilization, and complicated preparation processes. Achieve less ultrasonic energy loss, avoid cross-infection, and good conductivity

Inactive Publication Date: 2020-03-31
SHANGHAI LIKANG DISINFECTION HIGH TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the process of ultrasound diagnosis and treatment, the external ultrasound probe and coupling agent directly contact the patient's skin, mucous membrane of the cavity, and even contact the patient's open wound, ulcer, catheter and some equipment for maintaining vital signs, which is easy to cause cross-infection; currently, the market There are many kinds of medical ultrasonic disinfection coupling agent, such as Chinese patent CN105983107A provides a new type of medical disinfection and sterilization ultrasonic coupling agent, with magnolol as the main bactericidal component, syringic acid, anisic acid, dipotassium glycyrrhizinate and pandan Some researchers have shown that these plant extracts can only achieve antibacterial and antibacterial effects, but not rapid sterilization; for example, Chinese patent CN104189927A achieves bactericidal effect by compounding six kinds of Chinese herbal essential oils, and the mixed smell of various Chinese herbal essential oils is mixed. Closed B-ultrasound chamber is inconvenient to use frequently, and the preparation process is complicated; another example is to use chemical composition as bactericide: Chinese patent CN101249268A uses (0.05%-0.15%) polyhexamethylene biguanide, benzalkonium chloride, benzalkonium bromide , chlorhexidine acetate, trichlorophenoxydiphenyl ether, nano-silver or a combination of them as bactericidal ingredients; Chinese patent CN101219223A uses (0.2%-2%) 2,4,4-trichloro-2-hydroxy Phenyl ether is a bactericidal component and cannot be biodegraded, and the amount of chemical bactericide added is large, and it will remain on the skin after ultrasonic diagnosis, which has a certain stimulating effect on the skin

Method used

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  • Medical ultrasonic disinfection coupling agent and preparation method thereof
  • Medical ultrasonic disinfection coupling agent and preparation method thereof
  • Medical ultrasonic disinfection coupling agent and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] (1) Weigh 0.9 g of distearyth, add 86 g of purified water, stir and dissolve at 65° C. for 35 min, and obtain a transparent colloidal A system.

[0025] (2) Take by weighing chlorhexidine gluconate 0.05g, terpineol 0.008g, chitosan 0.2g, ethyl p-hydroxybenzoate 0.06g, propyl p-hydroxybenzoate 0.03g and join in 12g of propylene glycol and stir until Dissolution is complete, and B system is obtained.

[0026] (3) While stirring, add system B to system A and stir evenly, add purified water to 100 g, and mix evenly to obtain the medical ultrasonic disinfection coupling agent.

Embodiment 2

[0028] (1) Weigh 1.2 g of distearyth, add 83 g of purified water, stir and dissolve at 65° C. for 35 min, and obtain system A in the form of transparent colloid.

[0029] (2) Weigh 0.1g of chlorhexidine gluconate, 0.003g of terpineol, 0.3g of chitosan, 0.05g of methyl p-hydroxybenzoate, 0.04g of ethyl p-hydroxybenzoate and join in 15g of glycerin and stir evenly until Dissolution is complete, and B system is obtained.

[0030] (3) While stirring, add system B to system A and stir evenly, add purified water to 100 g, and mix evenly to obtain the medical ultrasonic disinfection coupling agent.

Embodiment 3

[0032] (1) Weigh 1.0 g of distearyth, add 84 g of purified water, stir and dissolve at 65° C. for 35 min, and obtain system A in the form of transparent colloid.

[0033] (2) Weigh 0.08g of chlorhexidine gluconate, 0.004g of terpineol, 0.1g of chitosan, and 0.105g of methyl p-hydroxybenzoate, add them to 6g of propylene glycol and 8g of glycerin and stir until they are completely dissolved to obtain system B .

[0034] (3) While stirring, add system B to system A and stir evenly, add purified water to 100 g, and mix evenly to obtain the medical ultrasonic disinfection coupling agent.

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Abstract

The invention discloses a medical ultrasonic disinfection coupling agent. The medical ultrasonic disinfection coupling agent comprises the following components in percentage by weight: 0.03 to 0.1% ofchlorhexidine gluconate, 0.002 to 0.01% of terpilenol, 0.1 to 0.5% of chitosan, 10 to 20% of a wetting agent, 0.8 to 1.6% of distearyl alcohol polyether, and 0.08 to 0.15% of a preservative, with thebalance being purified water. The invention also discloses a preparation method of the medical ultrasonic disinfection coupling agent. The medical ultrasonic disinfection coupling agent is colorless,non-toxic and non-irritant, has proper viscosity, good conductivity, low ultrasonic energy loss, high resolution ratio, clear ultrasonic development, high safety, and efficient, rapid and lasting disinfection and skin-moistening effects, can disinfect an ultrasonic probe at any time while realizing sterilizing, and avoids cross infection in clinical examination. In addition, the medical ultrasonic disinfection coupling agent is wide in raw material source, simple in preparation process, low in cost and easy to popularize and apply in the market.

Description

technical field [0001] The invention belongs to the technical field of medical disinfection, and in particular relates to a medical ultrasonic disinfection coupling agent. In addition, the invention also relates to a preparation method of the medical ultrasonic disinfection coupling agent. Background technique [0002] Medical ultrasonic couplant is one of the most frequently used consumables in clinical practice. Its characteristics should be harmless to the human body, non-irritating to the skin, non-allergic, easy to erase, good thixotropy and non-dripping, easy to operate, not easy to dry, Not easy to rancidity, clear ultrasonic imaging, suitable viscosity, non-greasy, easy to slide the probe, and at the same time can moisten the skin, eliminate air on the skin surface, good lubrication performance, easy to spread; the most important thing is that during ultrasonic examination, The ultrasonic coupling agent fills the tiny gaps between the probe and the contact surface, s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N47/44A01N43/16A01N31/04A01P1/00A01P3/00
CPCA01N31/04A01N43/16A01N47/44
Inventor 许芸张万国邹贤信李懋
Owner SHANGHAI LIKANG DISINFECTION HIGH TECH
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