Solvent system capable of effectively dissolving ornidazole or S-ornidazole and application thereof

Abstract

The invention discloses a solvent system capable of effectively dissolving ornidazole or S-ornidazole and an application thereof, the active component is ornidazole or S-ornidazole, and the solvent system is an organic solvent mixed by short-chain polyethylene glycol and propylene glycol; and preferably, the short-chain polyethylene glycol is polyethylene glycol 300 or/and polyethylene glycol 400.The solvent system can be used for preparing an ornidazole injection or a S-ornidazole injection. The method has the technical advantages which cannot be achieved in the prior art; the prepared ornidazole injection or the S-ornidazole injection has the preparation advantages of being simpler in prescription, safer in production, more stable in preparation, less in solvent amount, lower in impurity (especially genotoxic impurities) content, not prone to crystallization at low temperature, low in phlebitis occurrence rate, free of low-pH infusion irritation, and more suitable for patients withdisulfiram reaction sensitivity and the like. The clinical medication safety is ensured, and the medication compliance of a patient is better.

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