SNP markers and their application related to auxiliary diagnosis of non-small cell lung cancer in China

Abstract

The invention relates to a SNP marker related to the auxiliary diagnosis of non-small cell lung cancer in China and its application. The marker is rs2046210. The invention provides a technical method for screening high-risk groups of non-small cell lung cancer from the perspectives of molecular biology and gene diagnosis. This method is based on our previous research showing that BPA exposure level and rs2046210 locus jointly affect the susceptibility to non-small cell lung cancer in the Chinese population. Through the development of a highly sensitive BPA level measurement platform and the ingenious design of primers and probes for genotyping at the rs2046210 site, the high-risk population of non-small cell lung cancer can be identified, and the diagnosis of non-small cell lung cancer patients can be assisted. The identification method is ingenious It is simple, feasible, accurate and reliable, and can be promoted in hospitals at all levels. It provides help in assessing the risk of non-small cell lung cancer, and is helpful for clinical screening and early intervention of non-small cell lung cancer in this group of people.

Description

technical field [0001] The invention relates to the fields of genetic engineering and tumor medicine, in particular to a SNP marker related to the auxiliary diagnosis of non-small cell lung cancer in China and its application. Background technique [0002] Lung cancer is a common malignant tumor that seriously threatens the health of the people in our country. Its morbidity and mortality rate rank first among malignant tumors in my country. Among them, non-small cell lung cancer is the most common pathological type of lung cancer, accounting for about 80%-85% of all lung cancers. At present, there is still a lack of effective screening methods and early diagnosis methods for lung cancer. If screening and early diagnosis can be carried out more accurately for high-risk individuals of lung cancer, the prognosis of patients can be significantly improved, and a large amount of medical expenses can be saved for the country. [0003] Bisphenol A (BPA) is a common type of environ...

AI Technical Summary

Problems solved by technology

There is a genetic variation rs2046210 upstream of the ESR1 gene, which can significantly increase the risk of non-small cell lung cancer in people exposed to high levels of BPA

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