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A kind of graphene oxide/rosmarinic acid composite material and preparation method thereof

A technology of rosmarinic acid and composite materials, applied in the field of biomedicine, can solve the problems of safety, drug resistance of strains, etc.

Active Publication Date: 2021-09-10
安徽同欣富新材料科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, antibiotics such as amoxicillin have certain safety problems, and long-term use will cause strains to develop drug resistance

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  • A kind of graphene oxide/rosmarinic acid composite material and preparation method thereof
  • A kind of graphene oxide/rosmarinic acid composite material and preparation method thereof
  • A kind of graphene oxide/rosmarinic acid composite material and preparation method thereof

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preparation example Construction

[0032] In one aspect of the present invention, the present invention provides a preparation method of graphene oxide / rosmarinic acid composite material. This method directly uses rosmarinic acid to functionalize graphene oxide. Rosmarinic acid can be located between graphene oxide sheets and react with functional groups on graphene oxide sheets to expand the interlayer distance of graphene oxide. Therefore, on the one hand, rosmarinic acid prevents the agglomeration of graphene oxide due to van der Waals force and π-π stacking, thereby improving the antibacterial effect of graphene oxide. On the other hand, rosmarinic acid is on the graphene oxide sheet, and graphene oxide improves the stability and timeliness of rosmarinic acid, making the two synergistic, improving the overall graphene oxide / rosmarinic acid composite. Antimicrobial properties of materials. According to an embodiment of the invention, the method includes:

[0033] (1) Add rosmarinic acid to an organic solve...

Embodiment 1

[0041] Preparation of Graphene Oxide / Rosmarinic Acid Composite

[0042] (1) Disperse 500 mg of graphene oxide in 500 mL of N,N-dimethylformamide, and 500 W ultrasonic for 20 min to obtain a graphene oxide dispersion with a concentration of 1 mg / mL. Among them, the preparation process of graphene oxide is: take 1g of graphite oxide powder and disperse it in 500mL ultrapure water, ultrasonic treatment for 1.5h, centrifugation, remove the unexfoliated graphite oxide of the lower layer and the multilayer graphene oxide with larger mass, and The upper graphene oxide suspension was placed in a freeze dryer for drying to obtain a powdery solid, namely graphene oxide, denoted as GO.

[0043] (2) Add 0.25g of rosmarinic acid into 200mL of N,N-dimethylformamide and stir to dissolve, then add 0.0798g of N-hydroxysuccinimide (the number of moles is 1 times that of rosmarinic acid), and then Place it on a magnetic stirrer and slowly add 0.4655g 1-(3-dimethylaminopropyl)-3-ethylcarbodiimid...

Embodiment 2

[0046] Preparation of Graphene Oxide / Rosmarinic Acid Composite

[0047] (1) Disperse 500 mg of graphene oxide in 500 mL of tetrahydrofuran, and 500 W ultrasonic for 20 min to obtain a graphene oxide dispersion with a concentration of 1 mg / mL. Among them, the preparation process of graphene oxide is: take 1g of graphite oxide powder and disperse it in 500mL ultrapure water, ultrasonic treatment for 1.5h, centrifugation, remove the unexfoliated graphite oxide of the lower layer and the multilayer graphene oxide with larger mass, and The upper graphene oxide suspension was placed in a freeze dryer for drying to obtain a powdery solid, namely graphene oxide, denoted as GO.

[0048] (2) Add 0.5g rosmarinic acid into 200mL tetrahydrofuran and stir to dissolve, then add 0.2468g 4-pyrrolidinylpyridine (the number of moles is 1.2 times that of rosmarinic acid), and place it on a magnetic stirrer on ice Slowly add 0.6651g 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (2.5...

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Abstract

The invention relates to a graphene oxide / rosmarinic acid composite material and a preparation method thereof. The method comprises: (1) dissolving rosmarinic acid in an organic solvent, and then adding 1 to 2 mols of rosmarinic acid times the condensation activator and 1 to 3.5 times the condensation agent, adjust the pH of the solution, and react for 1 to 3 hours to obtain a reaction solution; (2) add the graphene oxide dispersion to the reaction solution to adjust the pH of the solution Afterwards, ultrasonic treatment, reaction for 24-30 hours, centrifugation, and freeze-drying, so as to obtain graphene oxide / rosmarinic acid composite material. The method is simple to operate and has mild reaction conditions, and the prepared composite antibacterial material has good antibacterial effect and has high application value.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to a graphene oxide / rosmarinic acid composite material and a preparation method thereof. Background technique [0002] Graphene oxide is a carbonaceous material. It is an oxygen-containing derivative of graphene prepared by ultrasonic treatment after oxidizing graphite with concentrated acid or strong oxidant. Its structure is basically the same as graphene, and it is composed of single-layer carbon Composed of atoms, it has a honeycomb-like two-dimensional planar structure. The difference is that the surface of the graphene oxide sheet contains a large number of hydroxyl groups and epoxy groups, while the edge of the sheet contains oxygen-containing groups such as carbonyl and carboxyl groups. These oxygen-containing functional groups endow graphene oxide with many properties such as good dispersibility, hydrophilicity, biocompatibility, etc. A large number of literatures have shown tha...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A01N59/00A01N37/40A01P3/00A01P1/00
CPCA01N37/40A01N59/00
Inventor 刘源森张松唐旭林凌吴鹏黄家琪徐长安
Owner 安徽同欣富新材料科技有限公司