Spin coupling network phase sensitive spectrum implementation method based on pure chemical shift

A technology of pure chemical shift and realization method, which is applied in the field of phase-sensitive spectrum realization of spin-coupling network based on pure chemical shift, can solve the problems of inaccurate measurement of J-coupling constant and spectral line broadening, so as to avoid spectral line broadening, Accurately measure, overcome the effect of phase distortion

Active Publication Date: 2020-04-10
XIAMEN UNIV
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Problems solved by technology

[0003] The main technical problem to be solved by the present invention is to provide a method for realizing phase-sensitive spectrum of spin-coupling network based on pure chemical shift, which can be applied to many spin-coupli...

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  • Spin coupling network phase sensitive spectrum implementation method based on pure chemical shift
  • Spin coupling network phase sensitive spectrum implementation method based on pure chemical shift
  • Spin coupling network phase sensitive spectrum implementation method based on pure chemical shift

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Embodiment Construction

[0028] The method proposed by the present invention can not only overcome the shortcomings of the traditional J spectrum, directly obtain the pair sum network information of the excited nucleus, but also overcome the problem of widening of the spectral peak width in the absolute value display mode, and realize a complete two-dimensional phase sensitive spectrum. Only one experiment is required to obtain a spectrum without a dispersion component, which greatly improves the measurement of spin-coupling network information.

[0029] Each step in the specific implementation process of the present invention is as follows:

[0030] Step 1, sample loading

[0031] Stir the prepared sample solution evenly with a tool and put it into the detection chamber of the nuclear magnetic spectrometer.

[0032] Specifically, in the sample loading process, you only need to input a command on the software to turn on the airflow switch, and then turn off the airflow after placing the sample.

[0...

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Abstract

The invention provides a spin coupling network phase sensitive spectrum implementation method based on pure chemical shift. The method mainly relates to spin excitation, selective repolymerization, pure chemical shift and phase-sensitive implementation. The method comprises: sending the uniformly stirred sample to be detected into a detection cavity of a nuclear magnetic spectrometer; performing tuning, shimming and field locking; measuring the non-selective pi/2 pulse width; acquiring a hydrogen spectrum by utilizing the standard sequence to obtain spectrum peak information; importing a preset sequence and setting experimental parameters, and executing data sampling; carrying out pure chemical shift data processing to obtain a two-dimensional spectrum containing J coupling information andpure chemical shift; and carrying out two-dimensional phase-sensitive processing on the obtained spectrogram. The method has the beneficial effects that (1) a single spin coupling network two-dimensional spectrum with a pure absorption peak line type can be obtained by only one experiment; (2) the J coupling constant can be accurately measured.

Description

technical field [0001] The invention relates to a nuclear magnetic resonance (NMR, Nuclear Magnetic Resonance) spectroscopy detection method, in particular to a method for realizing phase-sensitive spectrum of a spin coupling network based on pure chemical shift. Background technique [0002] Chemical shift and J-coupling information provide crucial information at the molecular level for organic chemistry, structure analysis and compositional analysis of biomolecules. In the traditional method, although the 2D J-decomposition spectrum can separate the chemical shift and J-coupling information, the coupling constants of independent homonuclear spin pairs are still unmeasured, and there are dispersion components, and the phase of the spectrum is distorted. Although the new J decomposition spectrum proposed at present can measure the J coupling constant, most of them cannot overcome the problem of the dispersion component in the spectrum. In the form of the absolute value spect...

Claims

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Application Information

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IPC IPC(8): G01N24/08
CPCG01N24/08
Inventor 林玉兰严明陈忠
Owner XIAMEN UNIV
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