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Substrate for biochip, biochip, method for manufacturing biochip, and method for preserving biochip

A technology of biochips and manufacturing methods, applied in the direction of measuring devices, instruments, scientific instruments, etc., can solve the problems of reduced detection accuracy, becoming noise, and reduced signal-to-noise ratio

Pending Publication Date: 2020-04-17
MITSUBISHI GAS CHEM CO INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0008] After the immobilized substance is immobilized on the substrate, it reacts with other physiologically active substances (substances to be detected: protein, antigen, etc.) In the case of detection, if a substance to be detected other than the molecule is immobilized on the part where the capture molecule is not immobilized, it will become noise during detection, which will cause a decrease in the signal-to-noise ratio (S / N ratio) and decrease the detection accuracy

Method used

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  • Substrate for biochip, biochip, method for manufacturing biochip, and method for preserving biochip
  • Substrate for biochip, biochip, method for manufacturing biochip, and method for preserving biochip
  • Substrate for biochip, biochip, method for manufacturing biochip, and method for preserving biochip

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Embodiment

[0255] Hereinafter, the present invention will be described in more detail based on examples, but the content of the present invention is not limited thereto.

[0256]

[0257] A polycarbonate sheet (manufactured by Mitsubishi Gas Chemical Co., Ltd., MU58U, thickness 0.8 mm) was irradiated with a UV-ozone irradiation device (manufactured by SEN Special Lighting Co., Ltd., SSP16-110, UV lamp: SUV110GS-36L) at an irradiation distance of 50 mm for 2 minutes. Next, 0.5 parts by weight of a polymer of polyethylene glycol monomethacrylate (manufactured by Sanyou Chemical Research Institute Co., Ltd., molecular weight of polyethylene glycol part: 350), 4,4'-diazidestilbene-2, 0.025 parts by weight of 2'-disulfonic acid (manufactured by Tokyo Chemical Industry Co., Ltd., 98%, hereinafter, referred to as bisazide) was dissolved in 75% ethanol aqueous solution, respectively, to obtain a coating solution of a non-specific adsorption preventing agent. Using a spin coater (manufactured b...

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Abstract

The purpose of the present invention is to provide a substrate for a biochip, a biochip, a method for manufacturing a biochip, and a method for preserving a biochip. The present invention pertains toa biochip having: a substrate having a hydrophilic reaction area; and a spot for a substance to be fixed that includes a biomaterial, the spot being disposed in the reaction area; the reaction area being enclosed by boundaries capable of retaining a liquid on the inner sides, and the spot furthermore including a thickening agent and / or a surfactant. The present invention also pertains to a methodfor manufacturing said biochip.

Description

technical field [0001] The present invention relates to a biochip for detection or analysis of biochemical reactions, a substrate for the biochip, a method for manufacturing the biochip, and a method for storing the biochip, particularly for allergens, using biological substances and the like immobilized on a substrate. Chips for inspection and diagnosis using antigen-antibody reactions such as inspections and tumor marker inspections. Background technique [0002] In recent years, microtiter plates for immunoassays in which antibodies or antigens are immobilized on plates, DNA chips in which nucleic acids are immobilized on chips, and the like have been widely used. In these chips, biological substances such as proteins and nucleic acids as substances to be immobilized are immobilized in the form of dots on the surface of a substrate in the form of a microarray. [0003] As a method for immobilizing proteins, etc., on a substrate, a method of applying BSA to vinyl polymeri...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/543G01N33/545G01N37/00
CPCG01N33/545G01N37/00G01N33/54393B01J19/0046B01J2219/00529B01J2219/00536B01J2219/00608B01J2219/0061
Inventor 泽野惠梨香高濑雄希田代英夫田代朋子
Owner MITSUBISHI GAS CHEM CO INC
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