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Soft tissue adhesive with antibacterial and hemostatic functions

An adhesive and soft tissue technology, used in surgical adhesives, applications, medical science, etc., can solve the problems of insufficient adhesive strength and single function, and achieve the effect of rapid hemostasis, convenient and safe application, and good fluidity.

Active Publication Date: 2020-04-21
杭州小青柠医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, the development of various soft tissue adhesives has become a research hotspot at home and abroad in recent years, but the ideal medical adhesive that really meets the clinical requirements has not yet appeared, and the current various adhesives are more or less Few have their own shortcomings, such as insufficient bonding strength, single function, etc.

Method used

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  • Soft tissue adhesive with antibacterial and hemostatic functions
  • Soft tissue adhesive with antibacterial and hemostatic functions
  • Soft tissue adhesive with antibacterial and hemostatic functions

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] An adhesive for soft tissue with antibacterial and hemostatic effects based on polysaccharide and hyperbranched polypeptide, which is composed of the following raw materials by mass percentage: oxidized carboxymethyl cellulose 25% and hyperbranched polypeptide polyethylene glycol graft copolymer 25%, the balance is phosphate buffered saline.

[0032] The molecular weight of the oxidized carboxymethyl cellulose is 250,000, and the degree of deacetylation is 90%.

[0033] The hyperbranched polypeptide in the hyperbranched polypeptide polyethylene glycol graft copolymer is a lysine three-generation peptide dendrimer, and the molecular weight of the polyethylene glycol terminated by amino groups at both ends is 2000.

[0034] The mass ratio of the oxidized carboxymethyl cellulose and the hyperbranched polypeptide polyethylene glycol graft copolymer is 1:1.

[0035] The use temperature of the adhesive for soft tissue is room temperature, and the use pH is 7.2-7.5.

Embodiment 2

[0037] An adhesive for soft tissue with antibacterial and hemostatic effects based on polysaccharide and hyperbranched polypeptide, which is composed of the following raw materials by mass percentage: oxidized carboxymethyl cellulose 25% and hyperbranched polypeptide polyethylene glycol graft copolymer 25%, the balance is phosphate buffered saline.

[0038] The molecular weight of the oxidized carboxymethyl cellulose is 250,000, and the degree of deacetylation is 90%.

[0039] The hyperbranched polypeptide in the hyperbranched polypeptide polyethylene glycol graft copolymer is a lysine three-generation peptide dendrimer, and the molecular weight of the polyethylene glycol terminated by amino groups at both ends is 2000.

[0040] The mass ratio of the oxidized carboxymethyl cellulose and the hyperbranched polypeptide polyethylene glycol graft copolymer is 1:2.

[0041] The use temperature of the adhesive for soft tissue is room temperature, and the use pH is 7.2-7.5.

Embodiment 3

[0043] The present embodiment is the preparation method of the adhesive for soft tissue of embodiment 1, comprising the following steps:

[0044] (1) at room temperature, the oxidized carboxymethyl cellulose and the hyperbranched polypeptide polyethylene glycol graft copolymer are respectively dissolved in the phosphate buffered saline of pH 7.2-7.5 to prepare a solution of 25g / L;

[0045] (2) The oxidized carboxymethyl cellulose and the hyperbranched polypeptide polyethylene glycol graft copolymer solution obtained in step (1) were loaded into a double-barreled syringe respectively, uniformly mixed with a mass ratio of 1:1, and then applied to the wound At room temperature, through the Schiff base reaction, a soft tissue adhesive with both antibacterial and hemostatic effects is obtained at room temperature, which firmly and lastingly adheres to the wound surface.

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Abstract

The invention provides a soft tissue adhesive with antibacterial and hemostatic functions. The soft tissue adhesive is prepared from the following raw materials in percentage by mass: 25% of oxidizedcarboxymethylcellulose, 25% of a hyperbranched polypeptide polyethylene glycol grafted copolymer and the balance of phosphate buffered saline, a preparation method of the soft tissue adhesive with antibacterial and hemostatic functions comprises the following steps: (1) respectively dissolving the oxidized carboxymethylcellulose and the hyperbranched polypeptide polyethylene glycol graft copolymerin the phosphate buffered saline with the pH value of 7.2-7.5 at room temperature to prepare a 25g / L solution; (2) respectively filling the oxidized carboxymethylcellulose solution and the hyperbranched polypeptide polyethylene glycol grafted copolymer solution obtained in the step (1) into a double-tube injector, uniformly mixing according to the mass ratio of 1: 1 and 1: 2, coating a wound withthe mixture, and carrying out Schiff base reaction to obtain the double-component high-strength rapid tissue adhesive based on polysaccharide and hyperbranched polypeptide within dozens of seconds atroom temperature.

Description

technical field [0001] The invention belongs to the technical field of medical biomaterials, and relates to an adhesive for soft tissue, in particular to an adhesive for soft tissue with both antibacterial and hemostatic functions. Background technique [0002] Medical tissue adhesives are mainly used in surgical operations such as cosmetic surgery and various wound sutures. They can quickly bond human biological tissues and promote wound healing, and can assist or partially replace sutures. The use of medical adhesives has a long history and plays a very important role in clinical practice. Specifically, it can be divided into soft tissue adhesives, dental adhesives, bone adhesives, and skin adhesives. Among them, due to the substantive structure of biological soft tissues covered with rich capillaries, sutures cannot achieve immediate hemostasis on wounds, and the suture process may cause tissue damage or even interfere with tissue function recovery. Compared with sutures...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/08A61L24/04A61L24/00C08G81/00
CPCA61L24/043A61L24/0042A61L24/001A61L24/0015C08G81/00A61L2400/04A61L2300/252A61L2300/404C08L1/286C08L87/00Y02P20/55
Inventor 顾忠伟毛宏理朱浩方
Owner 杭州小青柠医疗科技有限公司
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