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Method and system for ex-vivo heart perfusion

A cardiac, fluid technology for the preservation and evaluation of isolated hearts

Inactive Publication Date: 2020-04-24
UNIV HEALTH NETWORK
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, right ventricular functional parameters may be important predictors of organ outcome after transplantation and are currently unexplored

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  • Method and system for ex-vivo heart perfusion
  • Method and system for ex-vivo heart perfusion
  • Method and system for ex-vivo heart perfusion

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Embodiment Construction

[0057] Some strategies for ex vivo perfusion focus on different modes of work that enable graft assessment during perfusion. According to the first strategy, a two-chamber mode of operation can be employed, in which only the left atrium is supplied with blood and blood is ejected from the left ventricle to perfuse the coronary arteries. According to another strategy, a four-chamber working heart platform can be employed that uses a pump to load the left atrium and a reservoir to load the right atrium by gravity. However, the decoupled design of the load system may make it difficult to manipulate the left and right preloads independently. Additionally, such systems may rely on the use of reservoir height to control right atrial pressure, which limits the system's ability to facilitate precise control of atrial load throughout the perfusion period.

[0058] Figure 1A is a block diagram of an example system 100 for perfusing a heart 200 . In some embodiments, heart 200 is an a...

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Abstract

Systems and methods for performing perfusion and contractility assessments for a heart are provided. The system can operate in any of Langendorff mode, pump-supported working mode, passive working mode, and right-sided working mode. The system includes a reservoir from which one or more pumps are operable to supply a heart with fluids and collect fluids output therefrom. One or more clamps can beused to switch between Langendorff, pump-supported, passive, and right-sided working modes.

Description

[0001] Cross References to Related Applications [0002] This application claims the benefit of U.S. Provisional Patent Application No. 62 / 488,123, filed April 21, 2017, the entire contents of which are incorporated herein by reference. technical field [0003] This application relates to the preservation and evaluation of isolated hearts, and in particular to the perfusion behavior of the heart in various modes of operation. Background technique [0004] Heart transplantation is an important treatment option for many patients with advanced heart failure. However, its widespread application is limited by the paucity of available donor hearts compared with eligible recipients. Static cold storage, the accepted technique for preserving organs between cardiac resection and transplantation, does not provide a means of distinguishing transplants with reversible damage from those with irreversible damage. The isolated heart perfusion (EVHP) system has been developed to address d...

Claims

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Application Information

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IPC IPC(8): A01N1/02
CPCA01N1/0247
Inventor M·V·巴迪瓦拉V·劳J·W·祖B·格尔纳R·V·P·里贝罗辛立明
Owner UNIV HEALTH NETWORK
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