Method and system for ex-vivo heart perfusion

A cardiac, fluid technology for the preservation and evaluation of isolated hearts
CN111065264AInactive Publication Date: 2020-04-24UNIV HEALTH NETWORK
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
UNIV HEALTH NETWORK
Publication Date
2020-04-24
Estimated Expiration
Not applicable · inactive patent

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Abstract

Systems and methods for performing perfusion and contractility assessments for a heart are provided. The system can operate in any of Langendorff mode, pump-supported working mode, passive working mode, and right-sided working mode. The system includes a reservoir from which one or more pumps are operable to supply a heart with fluids and collect fluids output therefrom. One or more clamps can beused to switch between Langendorff, pump-supported, passive, and right-sided working modes.
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Description

[0001] Cross References to Related Applications

[0002] This application claims the benefit of U.S. Provisional Patent Application No. 62 / 488,123, filed April 21, 2017, the entire contents of which are incorporated herein by reference. technical field

[0003] This application relates to the preservation and evaluation of isolated hearts, and in particular to the perfusion behavior of the heart in various modes of operation. Background technique

[0004] Heart transplantation is an important treatment option for many patients with advanced heart failure. However, its widespread application is limited by the paucity of available donor hearts compared with eligible recipients. Static cold storage, the accepted technique for preserving organs between cardiac resection and transplantation, does not provide a means of distinguishing transplants with reversible damage from those with irreversible damage. The isolated heart perfusion (EVHP) system has been developed to address d...

Claims

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