Three-dimensional bionic self-healing hydrogel fiber scaffold composition and preparation method and application thereof
A technology of hydrogel fibers and fiber scaffolds, which is applied in the field of biomedicine, can solve the problems that the scaffolds do not have the strength of muscle kinematics and the synthesis process is complicated, and achieve good clinical application prospects, good biocompatibility, and increase the speed of tissue regeneration Effect
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Example Embodiment
[0052] Example 1
[0053] A three-dimensional bionic self-healing hydrogel fiber scaffold is prepared as follows:
[0054] Take the biocompatible material with a weight ratio of 99% and the nanomaterial with a weight ratio of 1% to form a composition for fiber stents; the biocompatible material is preferably polycaprolactone, and the nanomaterial is preferably single-layer graphite Ene.
[0055] The polycaprolactone is dissolved in a solvent 10 times the weight of the composition, and then graphene is added and mixed thoroughly to obtain a composition solution capable of forming a fiber membrane. The solvent is preferably dichloromethane.
[0056] After removing bubbles from the above graphene composition solution with an ultrasonic machine, inject it into the injector, output at a flow rate of 0.1ml / min, and spray it onto a receiving plate 30cm long and 20cm wide. The negative voltage is -4KV, the positive voltage is It is 12KV and the receiving distance is 25cm; the electrospinnin...
Example Embodiment
[0062] Example 2
[0063] A three-dimensional bionic hydrogel fiber scaffold is prepared as follows:
[0064] Take a biocompatible material with a weight ratio of 99% and a small molecule compound with a weight ratio of 1% to form a fiber scaffold composition; the biocompatible material is preferably polycaprolactone, and the nanomaterial is preferably melatonin .
[0065] The polycaprolactone is dissolved in a solvent 10 times the weight of the composition, and then melatonin is added and mixed thoroughly to obtain a composition solution capable of forming a fiber membrane. The solvent is preferably dichloromethane.
[0066] After the above melatonin composition solution is used with an ultrasonic machine to remove air bubbles, it is injected into the injection machine, output at a flow rate of 0.1ml / min, and sprayed onto a receiving plate 30cm long and 20cm wide, negative voltage -4KV, positive voltage It is 12KV and the receiving distance is 25cm; the electrostatic 25cm spinning ...
Example Embodiment
[0072] Example 3
[0073] A three-dimensional bionic hydrogel fiber scaffold is prepared as follows:
[0074] Take a biocompatible material with a weight ratio of 98%, a nanomaterial with a weight ratio of 1%, and a small molecule compound with a weight ratio of 1% as the fibrous scaffold composition; the biocompatible material is preferably polycaprolactone, The nano material is preferably a single-layer graphene, and the small molecule compound is melatonin.
[0075] The polycaprolactone is dissolved in a solvent 10 times the weight of the composition, and then graphene and melatonin are added and mixed thoroughly to obtain a composition solution capable of forming a fiber membrane. The solvent is preferably dichloromethane.
[0076] After the above-mentioned graphene and melatonin composition solution is removed with an ultrasonic machine, it is injected into the injection machine, output at a flow rate of 0.1ml / min, and sprayed onto a receiving plate with a length of 30cm and a w...
PUM
Property | Measurement | Unit |
---|---|---|
Storage modulus | aaaaa | aaaaa |
Loss modulus | aaaaa | aaaaa |
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap