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A kind of medical cationic polymer biopolymer material and its preparation method and application

A cationic polymer, biopolymer technology, applied in the field of medical cationic polymer biopolymer materials and preparation, cationic biopolymer materials and preparation fields, can solve problems such as self-dissolution failure, achieve excellent stability and mild reaction conditions , the effect of increasing the degradation half-life or dissolution time

Active Publication Date: 2021-12-31
湖南益安生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] At present, chitosan has been widely used, but due to its strong liquid absorption performance, it will dissolve itself in a short period of time after absorbing liquid. Excipients and drug slow-release agents are prone to self-dissolve in a short time after absorbing liquid in an environment with high humidity, resulting in failure. Therefore, it is urgent to study a raw material that can retain chitin-like biomacromolecular materials such as chitosan. New materials that have biological properties and can improve the degradation half-life or dissolution time to meet the current needs of various fields

Method used

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  • A kind of medical cationic polymer biopolymer material and its preparation method and application
  • A kind of medical cationic polymer biopolymer material and its preparation method and application
  • A kind of medical cationic polymer biopolymer material and its preparation method and application

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preparation example Construction

[0068] The present invention also provides the preparation method of the medical cationic polymer biopolymer material shown in above-mentioned formula (1), comprises the steps:

[0069] S1, the chitin-based polymer material and the compound 1 having the following formula (2) undergo a ring-opening addition reaction to obtain a compound 3 having the following formula (4); the specific reaction process is as follows:

[0070] First, the chitin biopolymer material is dissolved in water or an acidic aqueous solution (pH is acidic) to obtain a chitin biopolymer solution, and then according to the amount of the primary hydroxyl group in the chitin biopolymer material: the substance of compound 1 The ratio of the amount is 1:(0.1~2) (preferably 1:1.5), add compound 1 to the chitin biopolymer solution, stir at room temperature for 1~3 days, preferably 3 days; after the reaction is completed, stir rapidly , slowly added ethanol solution, compound 3 was precipitated. Filter, wash with ...

Embodiment 1

[0095] According to the amount of the substance of the primary hydroxyl group in the chitosan acetate: the ratio of the amount of the substance of compound 1 (allyl glycidyl ether) as shown in formula (7) is 1: 1.5, take the refined chitosan B Acetate (deacetylation degree: more than 95%) and allyl glycidyl ether (for example: chitosan acetate 20g, allyl glycidyl ether 21.2g), stand-by;

[0096] Chitosan acetate is added in proportion to purified water (corresponding to 600ml) and stirred for dissolution to obtain a chitosan acetate solution with a mass concentration of 3%. Add the weighed allyl glycidyl ether and stir at room temperature for 24 hours. The feed solution was freeze-dried for 2 days, and after drying, it was taken out and washed 3 times with absolute ethanol, each time with 200 ml of absolute ethanol, stirred for 10 min, then filtered and dried to obtain compound 3.

[0097] According to the ratio of the amount of the substance of the amino group in the obtained...

Embodiment 2

[0105] The difference between this embodiment and embodiment 1 is:

[0106] Compound 1 adopts the compound shown in formula (6): (1,2-epoxy-5-hexene).

[0107] Others refer to the method of Example 1 to obtain a high-molecular polymer sponge, which is designated as sample A2.

[0108] The chemical structural formula of the compound 3 obtained in the present embodiment 2 is specifically:

[0109]

[0110] One of the chemical structural formula of the sample A2 that present embodiment finally makes is:

[0111]

[0112] Also according to the reaction principle, sample A2 may also contain, the two ends of Y-containing compound 2 (2,2'-(1,2-ethylenedioxy) diethanethiol) are respectively connected with the primary hydroxyl groups at different positions. Compounds containing other linking structures of X compound 1 (1,2-epoxy-5-hexene).

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Abstract

The invention discloses a medical cationic polymer biopolymer material, a preparation method and application thereof. Wherein: the cationic polymer biopolymer material comprises a compound having a chemical structural formula as shown in formula (1): in: X is an atom or group capable of covalent bonding, specifically comprising C or N or O or other A covalently bonded hydrocarbon or hydrocarbon-derived compound group; Y is specifically a hydrocarbon or hydrocarbon-derived compound group containing C, N, or O or other covalently bonded hydrocarbons or hydrocarbon-derived compound groups. The medical biopolymer material is obtained by modifying chitin-like polymer materials, and the chitin-like polymer materials include chitin and its derivatives and derivative salts; the material obtained after modification has a longer dissolution time , so that its degradation or dissolution time can be increased, so that it can be better used in agriculture, industry, especially in the field of medicine, especially in biological dressings and drug sustained-release carriers, and the liquid absorption of the modified polymer material is greater promote.

Description

technical field [0001] The invention belongs to the technical field of medical polymer materials, and in particular relates to a medical cationic polymer biopolymer material and its preparation method and application, especially a cationic biopolymer material obtained after modification of a chitin-like polymer material and its preparation Methods and applications. [0002] technical background [0003] Chitin, the chemical formula is (C 8 h 13 o 5 N) n , also known as chitin, chitin, English name Chitin, chemical name β-(1,4)-2-acetylamino-2-deoxy-D-glucose. It was discovered by French scholar Braconno in 1811 and extracted from crustacean shells by Ogier in 1823. Chitosan (Chitosan) is the product of N-deacetylation of chitin (generally, chitosan with more than 55% of the N-acetyl group removed is called chitosan), and chitin, chitosan, and cellulose have similar Chemical structure, cellulose is a hydroxyl group at the C2 position, chitin and chitosan are replaced by ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08B37/08A61L24/08A61L24/00A61L15/28A61L15/42A61K47/36
CPCC08B37/003A61L24/08A61L24/0036A61L24/0042A61L15/28A61L15/425A61L15/42A61K47/36A61L2400/04C08L5/08
Inventor 郭锦秀梁瑶
Owner 湖南益安生物科技有限公司
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