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Microbial agent for improving muscle atrophy and application of microbial agent

A microbial agent, muscle atrophy technology, used in applications, muscular system diseases, neuromuscular system diseases, etc.

Inactive Publication Date: 2020-05-22
农业农村部食物与营养发展研究所
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, no studies have looked for gut microbial strains that improve muscle atrophy

Method used

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  • Microbial agent for improving muscle atrophy and application of microbial agent
  • Microbial agent for improving muscle atrophy and application of microbial agent
  • Microbial agent for improving muscle atrophy and application of microbial agent

Examples

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Embodiment 1

[0023] The method of the clinical cohort (Cohort study) was used to carry out the protocol of this example. The embodiment of the present invention is registered by the Chinese Clinical Registration Center (ChiCTR 1800017765).

[0024] as per Figure 5 Screening by the process shown: by recruiting hematopoietic stem cell transplantation patients with long-term muscle atrophy, and by conducting a two-month high-quality protein nutrition intervention (calorie intake 35kcal / kg / d, protein intake 1.5g / kg / d; the protein is composed of animal protein and vegetable protein in a mass ratio of 1:1, wherein the vegetable protein is soybean protein isolate (YP928H, Yuwang Group, Shandong, China), and the animal protein is whey protein (Hilmar9410, Livingston, CA, USA)). Two months later, the muscle atrophy improvement effect was judged by muscle CT scan. Afterwards, the enrolled population was divided into two groups according to the effect of muscle improvement (muscle CT scan and gr...

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Abstract

The invention provides a microbial agent for improving muscle atrophy and an application of the microbial agent, and relates to the technical field of applications of intestinal bacteria. The microbial agent includes intestinal bacteria, the intestinal bacteria include ruminococcus and / or veillonella, and experiments verify that the ruminococcus and / or the veillonella in intestines both can improve the muscle atrophy symptom, increase a muscle area, improve muscle grip, have a significant positive correlation with the improvement of the muscle atrophy, and can be used to improve the muscle atrophy symptom.

Description

technical field [0001] The invention belongs to the technical field of intestinal bacteria application, and in particular relates to a microbial agent for improving muscle atrophy and its application. Background technique [0002] Constituting about 40% of body weight, skeletal muscle plays a vital role in maintaining human health, including amino acid and glucose metabolism, protein storage, and exercise. Muscle atrophy is a chronic metabolic disease commonly faced by people in modern society. Long-term lack of exercise, the elderly, cancer patients and people receiving high-dose hormone therapy will all face varying degrees of muscle atrophy. Studies have shown that muscle atrophy has become an independent factor affecting death. Therefore, how to effectively improve muscle atrophy has become an urgent health problem to be solved. [0003] Previous studies mainly studied the mechanism of muscle atrophy from the perspective of cell signal transduction pathways. Unfortuna...

Claims

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Application Information

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IPC IPC(8): A61K35/741A61P21/00A23L33/135
CPCA23V2002/00A61K35/741A23L33/135A61P21/00A61K2300/00A23V2200/316
Inventor 任广旭唐振闯杨祯妮程广燕
Owner 农业农村部食物与营养发展研究所
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