Chiral mesoporous core-shell structure silica nanoparticles and its preparation method and application

Abstract

The invention relates to a chiral mesoporous core-shell structure silicon dioxide nanoparticle and its preparation method and application, belonging to the technical field of nanomaterial preparation and pharmaceutical preparations. The present invention is the first to use L-leucine methyl ester hydrochloride as Starting from the reactants, chiral gel factors were synthesized, and then chiral mesoporous core-shell silica nanoparticles were synthesized. The silica nanoparticles have potential advantages in the loading and release of chiral drugs, and the core-shell structure The shell structure material has very excellent structure and composition characteristics. In addition, the synthesized nano silicon carrier has abundant pores, large specific surface area, excellent adsorption performance and strong drug loading capacity.

Description

Technical field[0001]The present invention belongs to the nanomaterial preparation and the technical field of the pharmaceutical preparation, and more particularly to chiral mesoporous nuclear-shell structure silica nanoparticles and preparation methods and applications thereof.Background technique[0002]The chiral is one of the basic properties of nature. It is large to the operational orbit of the celestial planet, which is small to biological macromolecular DNA and small molecules, amino acids, etc., are unsmorled. At present, the research of chiral drugs, split, chiral catalysis, chiral identification is still the hotspots and frontiers of scientific research. The chiral is generally, such as natural amino acids are L-type, while natural sugars are mostly D-type. Similarly, the gel factor itself has a chiral, and the chiral has an important influence on the morphology of the gel factor and the shape of the fiber. Various applications of developing chiral hymnolecular gels have gr...

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Problems solved by technology

However, it is actually very difficult to control the good dispersion of HMSs

For example, Le et al. used CTAB as an inorganic template to prepare calcium carbonate chiral mesoporous nanospheres, but the interparticle aggregation was serious; Shi et al. selected C 18 h 37 Si(OCH 3 ) 3 As hard templates, HMSs with different outer diameters (usually around 100–200 nm) were prepared, and the thickness of the mesoporous shell could be tuned in the range of 8 nm to 30 nm, however, the template molecule C 18 h 37 Si(OCH 3 ) 3 More expensive (document: Du, X., & He, J. (2011). Spherical silica micro / nanomaterials with hierarchical structures: synthesis and applications. Nanoscale, 3 (10), 3984-4002.)

In addition, people have successfully synthesized chiral mesoporous core-shell silica nanoparticles using achiral cationic surfactants as templates, chiral small molecules or chiral anionic colloids as chiral inducers, but the reaction conditions are complex, And it is difficult to achieve single chiral control (document: Hu, Y., et al. (2008). "Synthesis of Enantiomorphic Excessive Helical Mesoporous Silicas Using Chiral Molecular Dopants." Chemistry Letters37 (11): 1160-1161.)

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