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Method for extracting hyperoside from hypericum monogynum

A technology of hypericin and hypericum, applied in chemical instruments and methods, preparation of sugar derivatives, production of bulk chemicals, etc., can solve the problems of changing fragrance profile, loss of top fragrance, loss of freshness of products, etc. Avoid loss of active ingredients, improve quality and yield

Inactive Publication Date: 2020-06-02
南京西博恩生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Water distillation and solvent extraction will inevitably cause changes in components, thereby changing the entire fragrance profile, and often lose top notes, the product loses its freshness, and pollution from solvent residues is inevitable

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] A method for extracting hypericin from hypericum wort, comprising the following steps:

[0019] (1) Coarsely crush fresh hypericum walnuts and immerse in water for 25 minutes, then put them into a sieve basket and immerse the whole in liquid nitrogen for 50 minutes, then lift it up and place it at room temperature for 8 minutes, and then immerse the sieve basket in liquid nitrogen as a whole 50 minutes, so repeated 3 times;

[0020] (2) drying the hypericum in step (1) at low temperature, crushing, and passing through a 20-mesh sieve to obtain hypericum powder;

[0021] The low-temperature vacuum drying process is as follows: stack St. John's Wort alternately in a vacuum drying oven, control the vacuum degree to 0.009Mpa, and dry the St. John's Wort until the water content is below 5% at a vacuum drying temperature of 40°C;

[0022] (3) Mix Hypericum powder with 0.05 times the weight of β-glucosidase and let it stand for 50 minutes, then mix it with acetone and put it ...

Embodiment 2

[0025] A method for extracting hypericin from hypericum wort, comprising the following steps:

[0026] (1) Coarsely crush fresh hypericum walnuts and immerse in water for 20 minutes, then put them into a sieve basket and immerse the whole in liquid nitrogen for 30 minutes, then lift it up and place it at room temperature for 5 minutes, and then immerse the sieve basket in liquid nitrogen as a whole 30 minutes, so repeated 2 times;

[0027] (2) drying the hypericum in step (1) at low temperature, pulverizing, and passing through a 5-mesh sieve to obtain hypericum powder;

[0028] The low-temperature vacuum drying process is as follows: stack St. John's Wort alternately in a vacuum drying oven, control the vacuum degree to 0.009Mpa, and dry the St. John's Wort until the water content is below 5% at a vacuum drying temperature of 40°C;

[0029] (3) Mix hypericum wort powder with 0.01 times the weight of pectinase and let it stand for 30 minutes, then mix it with ethanol and put ...

Embodiment 3

[0032] A method for extracting hypericin from hypericum wort, comprising the following steps:

[0033] (1) Coarsely crush fresh St. John's Wort and immerse in water for 30 minutes, then put it into a sieve basket and immerse it in liquid nitrogen for 60 minutes, then lift it up and place it at room temperature for 10 minutes, and then immerse the sieve basket in liquid nitrogen as a whole 60 minutes, so repeated 3 times;

[0034] (2) drying the hypericum in step (1) at low temperature, crushing, and passing through a 30-mesh sieve to obtain hypericum powder;

[0035] The low-temperature vacuum drying process is as follows: stack St. John's Wort alternately in a vacuum drying oven, control the vacuum degree to 0.009Mpa, and dry the St. John's Wort until the water content is below 5% at a vacuum drying temperature of 40°C;

[0036] (3) Mix Hypericum powder with 0.08 times the weight of cellulase and let it stand for 60 minutes, then mix it with acetone and put it into the extra...

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PUM

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Abstract

The invention discloses a method for extracting hyperoside from hypericum monogynum, and belongs to the technical field of hyperoside extraction. The method comprises the following steps: (1) coarselycrushing fresh hypericum monogynum, then putting the crushed hypericum monogynum into a sieve basket, integrally immersing the sieve basket into liquid nitrogen for treatment, and repeating the stepsfor 2-3 times; (2) drying and crushing the hypericum monogynum in the step (1) at low temperature to obtain hypericum monogynum powder; (3) extracting the hypericum monogynum powder by adopting supercritical CO2 extraction; and (4) allowing CO2 containing the extract to flow out of the extraction kettle, and allowing the CO2 to enter a separation kettle for reduced pressure separation so as to obtain the hyperoside. According to the method for extracting the hyperoside from the hypericum monogynum provided by the invention, the loss of the hyperoside in the extraction process of the hypericummonogynum is prevented from being considered, and the quality and yield of the hyperoside extracted from the hypericum monogynum are improved.

Description

technical field [0001] The invention relates to a method for extracting hypericin in natural plants, in particular to a method for extracting hypericin from hypericin. Background technique [0002] Hyperoside is also known as hyperoside-3-O-β-D-galactopyranoside. Belongs to flavonol glycosides. The aglycon is hyperoside, the sugar group is galactopyranose, and the 3-position O atom of hyperoside is connected to the sugar group by a β-glycosidic bond. Molecular formula C21H20O12, molecular weight 464.3763. Hyperin has been proven to treat cardiovascular diseases, and has antispasmodic and analgesic effects, protects gastric mucosa, liver tissue, regulates blood lipids, enhances immunity, resists depression and protects against heart and brain ischemia. [0003] The traditional hyperin extraction process mainly includes water distillation, solvent extraction, supercritical fluid extraction, direct steam distillation, and microwave-assisted extraction process, while ultrason...

Claims

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Application Information

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IPC IPC(8): C07H1/08C07H17/07
CPCC07H1/08C07H17/07Y02P20/54
Inventor 董妍
Owner 南京西博恩生物科技有限公司
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