Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

A kind of polyethylene glycol-based hydrogel and its preparation method and application

A polyethylene glycol-based and polyethylene glycol-amino technology, which is applied in the field of preparation of polyethylene glycol-based hydrogels, can solve the problems of poor mechanical properties of hydrogels, poor gelation effect of hydrogels, and biological effects. Compatibility and other issues, to achieve good gelation effect, short gelation time, and improve the effect of biocompatibility

Active Publication Date: 2021-07-13
SOUTHWEST JIAOTONG UNIV
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] (1) The preparation process is complicated, the catalyst is difficult to remove, and other mixed substances are easily produced;
[0005] (2) The gelling effect of the hydrogel is poor, and the mechanical properties of the hydrogel are poor;
[0006] (3) It is easy to produce immunogenicity and affect its biocompatibility

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of polyethylene glycol-based hydrogel and its preparation method and application
  • A kind of polyethylene glycol-based hydrogel and its preparation method and application
  • A kind of polyethylene glycol-based hydrogel and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] The preparation method of the polyethylene glycol-based hydrogel of the present embodiment comprises the following steps:

[0057] (1) Synthesis of four-arm PEGNB

[0058] Using four-arm polyethylene glycol amino solution and NB solution as raw materials, condensing agent HATU, and organic base DIPEA as assistance, react under inert and sealed conditions to obtain PEGNB solution, and then add the PEGNB solution to ice ether Stir in medium, obtain a waxy substance by suction filtration, and purify the waxy substance to obtain four-arm PEGNB;

[0059] (2) Preparation of polyethylene glycol-based hydrogel

[0060] The PEGNB prepared in step (1) is mixed with polyethylene glycol dithiol, I2959 working solution and deionized water, the mass percent concentration of PEGNB is 6wt%, and the mass percent concentration of polyethylene glycol dithiol is 1.1wt% , the mass percent concentration of I2959 is 0.9wt%, and the mass percent concentration of deionized water is 92wt%, to ...

Embodiment 2

[0062] The preparation method of the polyethylene glycol-based hydrogel of the present embodiment comprises the following steps:

[0063] (1) Synthesis of four-arm PEGNB

[0064] (11) Dissolve 2 g of four-arm polyethylene glycol amino with a molecular weight of 4000 to 6000 in a sufficient amount of organic solvent to obtain a four-arm polyethylene glycol amino solution;

[0065] (12) Weigh 2 g of HATU, add 0.5 g of NB and a sufficient amount of organic solvent under an inert atmosphere, dissolve for 5 minutes, add 2 ml of DIPEA and mix until HATU is completely dissolved to obtain a solution product;

[0066] (13) Add the solution product prepared in step (12) dropwise into the four-arm polyethylene glycol amino solution, and react under inert and sealed conditions to obtain a PEGNB solution;

[0067] (14) The PEGNB solution was added to 200 mL of glacial ether and stirred, and a wax was obtained by suction filtration, and the wax was purified.

[0068] The specific process ...

Embodiment 3

[0072] The preparation method of the polyethylene glycol-based hydrogel of the present embodiment comprises the following steps:

[0073] (1) Synthesis of four-arm PEGNB

[0074] (11) Dissolve 2 g of four-arm polyethylene glycol amino with a molecular weight of 4000 to 6000 in a sufficient amount of organic solvent to obtain a four-arm polyethylene glycol amino solution;

[0075] (12) Weigh 3g of HATU, add 1g of NB and a sufficient amount of organic solvent under an inert atmosphere, dissolve for 10mins, add 3ml DIPEA and mix until HATU is completely dissolved to obtain a solution product;

[0076] (13) Add the solution product prepared in step (12) dropwise into the four-arm polyethylene glycol amino solution, and react under inert and sealed conditions to obtain a PEGNB solution;

[0077] (14) The PEGNB solution was added to 200 mL of glacial ether and stirred, and a wax was obtained by suction filtration, and the wax was purified.

[0078] The specific process of the abov...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
degree of graftingaaaaaaaaaa
degree of graftingaaaaaaaaaa
Login to View More

Abstract

The invention discloses a polyethylene glycol-based hydrogel, a preparation method and application thereof, and belongs to the technical field of gel material preparation. Its preparation method includes: using four-arm polyethylene glycol amino group and norbornene as raw materials, synthesizing four-arm PEGNB under the assistance of condensing agent HATU and organic base DIPEA; then PEGNB, polyethylene glycol dithiol and photoinitiated The agent I2959 triggers a click chemical reaction under the action of ultraviolet light to form a gel, and then on the basis of the gel formation, the PEG-based hydrogel is modified with arginyl-glycyl-aspartic acid tripeptide. The preparation technology step of the invention is simple, the copolymer is formed through photocatalysis, and the problem that the catalyst is difficult to remove is avoided. The invention can realize the controllability of the hardness and mechanical properties of the hydrogel by changing the ratio of substances in the hydrogel precursor formula. The invention has shorter gelation time and good gel stability, and establishes a new in vitro research model simulating the extracellular matrix in vivo.

Description

technical field [0001] The invention relates to the technical field of gel materials, in particular to a preparation method and application of a polyethylene glycol-based hydrogel. Background technique [0002] Polyethylene glycol (PEG) is a water-soluble polymer compound, which has many advantages such as low toxicity, non-coagulation and good biocompatibility, and is widely used in medicine, hygiene, chemical industry, food and other fields. . An important application of PEG is the preparation of hydrogels. Hydrogel is a highly hydrophilic polymeric network obtained by chemically initiating, ionizing radiation or ultraviolet irradiation, polymerizing and crosslinking one or more monomers. Usually, a small amount of cross-linking agent needs to be added during the formation of hydrogel. Hydrogels have a wide range of applications in the biomedical field. PEG-based hydrogels are more similar to living tissue than other synthetic biomaterials. [0003] At present, there ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): C08J3/075C08J3/28C08L71/02C12N5/00
CPCC08J3/075C08J3/28C08J2371/02C08J2471/02C12N5/0068C12N2533/40
Inventor 刘艳秋苏晨文丁永会杨舒朱萌李乐
Owner SOUTHWEST JIAOTONG UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com