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Complex Probiotics for Diabetes Improvement

A compound probiotic and diabetes technology, applied in the field of microorganisms, can solve the problems of the inability to increase the sugar reabsorption rate of the renal tubules, increase glucose utilization, and increase the sugar excretion of pregnant women, etc., and achieve a significant effect of improving diabetes and good health effects. Effect

Active Publication Date: 2020-10-02
成都六然医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Reasons: the fetus obtains more glucose from the mother; renal plasma flow and glomerular filtration rate increase during pregnancy, but the renal tubular sugar reabsorption rate cannot increase accordingly, resulting in increased glucose excretion in some pregnant women; estrogen and progesterone increase maternal glucose utilization

Method used

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  • Complex Probiotics for Diabetes Improvement
  • Complex Probiotics for Diabetes Improvement
  • Complex Probiotics for Diabetes Improvement

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0030] 1. Activated bacteria:

[0031] Lactobacillus casei CGMCC NO.4775: Take a loop of Lactobacillus casei and inoculate it into the MRS solid medium for streaking, and culture it anaerobically at 37°C for 24 hours. Pick a single colony with good growth in the plate and inoculate it into MRS liquid medium for activation, and culture it anaerobically to 1*10 8 cfu / ml Lactobacillus casei CGMCC NO.4775 seed solution, use lactic acid to adjust the pH value to 6.0.

[0032] Lactobacillus rhamnosus CGMCC NO.3994: The cultivation method is the same as above.

[0033] 2. Configure liquid

[0034] Preparation of cochlearol E solution: use water, Tween 80 (mass fraction 1%), and chitosin A to prepare a solution with a concentration of chitosin A of 5 mg / kg.

[0035] 3. Fermentation broth preparation

[0036] a. Lactobacillus casei CGMCC NO.4775 fermentation liquid: Lactobacillus rhamnosus CGMCC No. 3698 seed liquid is activated in MRS liquid medium, anaerobic culture is 24h, and t...

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Abstract

The invention discloses a compound probiotic for improving diabetes. The compound probiotic includes lactobacillus casei CGMCC NO.4775, lactobacillus rhamnosus CGMCC NO.3994 and other necessary adjuvants; as further optimization, a fermentation medium of the lactobacillus casei CGMCC NO.4775 contains cochlearol E; and the compound microbial agent can also include other probiotics, such as lactobacillus casei and lactobacillus paracasei. The compound microbial agent can be prepared into oral liquids, lyophilized powder, capsules, etc., and preferred as the oral liquids; and the compound microbial agent can also be used for fermenting food so as to prepare health food.

Description

technical field [0001] The invention relates to a compound probiotic for improving diabetes and belongs to the technical field of microorganisms. Background technique [0002] Probiotics have many beneficial functions in the human organism. Probiotics can effectively inhibit the growth of pathogenic bacteria, such as Clostridium perfringens, Escherichia coli, Staphylococcus, etc., to prevent food poisoning. Probiotic microorganisms, such as lactobacilli, bifidobacteria, etc., can improve immune function, enhance the absorption of vitamin and mineral compounds, and stimulate the production of organic acids and amino acids. They can also produce various enzymes, such as lipase and coenzyme A, etc. Molecular and genetic studies have determined that the beneficial effects of probiotics may be based on the following four mechanisms: ① antagonism by producing antibacterial substances; ② competition with pathogens for adhesion to epithelial cells and nutrients; ③ host immune regu...

Claims

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Application Information

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IPC IPC(8): A61K35/747A61P3/10A23L33/135C12N1/20C12R1/245C12R1/225
CPCA23L33/135A23V2002/00A61K35/747A61P3/10C12N1/20A61K2300/00A23V2200/328
Inventor 赵一鸣
Owner 成都六然医疗科技有限公司
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