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Stem cell-loaded biological material for treating colitis and preparation method of stem cell-loaded biological material

A technology of biomaterials and stem cells, applied in the field of stem cell-loaded biomaterials for the treatment of colitis and its preparation, can solve problems such as increased growth hormone, endocrine disorders, and greater impact on treatment effects, and achieve rich sources of raw materials, long course of treatment, and preparation The effect of simple method

Inactive Publication Date: 2020-06-05
CHENGDU ZHIA TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It can be seen that the choice of a good stem cell carrier has a great influence on the therapeutic effect
However, the addition of insulin-like growth factor C in this invention will lead to an increase in growth hormone and easily cause endocrine disorders

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027]A stem cell-loaded biological material for treating colitis, characterized in that it is made from the following raw materials in parts by weight: 3-(2-propenylselenoyl)-L-alanine / 2,3,5, 10 parts of 4-tetrahydroxystilbene glucoside / 2-methacryloyloxyethyl phosphorylcholine / allyl triethoxysilane copolymer, 0.03 parts of adipose-derived mesenchymal stem cells, 1 part of trilysine , 2 parts of polyethylene glycol diacrylate, 1 part of propylene cyclodextrin, 0.02 part of azobisisobutylamidine hydrochloride, 0.2 part of mesoporous calcium phosphate nanoparticles, and 30 parts of water.

[0028] The 3-(2-propenylselenyl)-L-alanine / 2,3,5,4-tetrahydroxystilbene glucoside / 2-methacryloyloxyethyl phosphorylcholine / allyl The preparation method of base triethoxysilane copolymer comprises the steps of: 3-(2-propenyl selenyl)-L-alanine, 2,3,5,4-tetrahydroxy stilbene glucoside, Add 2-methacryloyloxyethylphosphorylcholine, allyltriethoxysilane, and azobisisobutyronitrile into dimethyl s...

Embodiment 2

[0031] A stem cell-loaded biological material for treating colitis, characterized in that it is made from the following raw materials in parts by weight: 3-(2-propenylselenoyl)-L-alanine / 2,3,5, 12 parts of 4-tetrahydroxystilbene glucoside / 2-methacryloyloxyethyl phosphorylcholine / allyl triethoxysilane copolymer, 0.035 parts of bone marrow mesenchymal stem cells, 1.5 parts of trilysine , 2.3 parts of polyethylene glycol diacrylate, 1.2 parts of propylene cyclodextrin, 0.03 parts of azobisisobutylimidazoline hydrochloride, 0.3 parts of mesoporous calcium phosphate nanoparticles, and 32 parts of water.

[0032] The 3-(2-propenylselenyl)-L-alanine / 2,3,5,4-tetrahydroxystilbene glucoside / 2-methacryloyloxyethyl phosphorylcholine / allyl The preparation method of base triethoxysilane copolymer comprises the steps of: 3-(2-propenyl selenyl)-L-alanine, 2,3,5,4-tetrahydroxy stilbene glucoside, Add 2-methacryloyloxyethylphosphorylcholine, allyltriethoxysilane, and azobisisoheptanonitrile to...

Embodiment 3

[0035] A stem cell-loaded biological material for treating colitis, characterized in that it is made from the following raw materials in parts by weight: 3-(2-propenylselenoyl)-L-alanine / 2,3,5, 15 parts of 4-tetrahydroxystilbene glucoside / 2-methacryloyloxyethyl phosphorylcholine / allyl triethoxysilane copolymer, 0.04 parts of umbilical cord mesenchymal stem cells, 2 parts of trilysine , 2.5 parts of polyethylene glycol diacrylate, 1.5 parts of propylene cyclodextrin, 0.035 parts of azobiscyanovaleric acid, 0.35 parts of mesoporous calcium phosphate nanoparticles, and 35 parts of water.

[0036] The 3-(2-propenylselenyl)-L-alanine / 2,3,5,4-tetrahydroxystilbene glucoside / 2-methacryloyloxyethyl phosphorylcholine / allyl The preparation method of base triethoxysilane copolymer comprises the steps of: 3-(2-propenyl selenyl)-L-alanine, 2,3,5,4-tetrahydroxy stilbene glucoside, Add 2-methacryloyloxyethylphosphorylcholine, allyltriethoxysilane, and azobisisobutyronitrile to N,N-dimethylac...

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Abstract

The present invention discloses a stem cell-loaded biological material for treating colitis. The stem cell-loaded biological material is characterized by comprising the following raw materials in parts by weight: 10-20 parts of 3-(2-propenylseleno)-L-alanine / 2,3,5,4-tetrahydroxystilbene glucoside / 2-methacryloyloxyethyl phosphate choline / allyl triethoxysilane copolymer, 0.03-0.05 part of stem cell,1-3 parts of trilysine, 2-3 parts of polyethylene glycol diacrylate, 1-2 parts of allyl cyclodextrin, 0.02-0.05 part of an aqueous initiator, 0.2-0.5 part of mesoporous calcium phosphate nanoparticleand 30-40 parts of water. The disclosed stem cell-loaded biological material for treating colitis has a good therapeutic effect on colitis and high efficiency. The medicinal active ingredients can fully exert medicinal effects without causing damages to human body tissues. The stem cell-loaded biological material can slowly release stem cells to the damaged sites, enhances retention rate and stability of the stem cells in the damaged sites, at the same time can improve nutrients for human body, improves therapeutic effects, and can also play a health-care role.

Description

technical field [0001] The invention relates to the technical fields of biomedicine and tissue engineering, in particular to a stem cell-loaded biological material for treating colitis and a preparation method thereof. Background technique [0002] Colitis refers to inflammatory lesions of the colon caused by various reasons. It can be caused by organisms such as bacteria, fungi, viruses, parasites, and protozoa, and can also be caused by allergic reactions and physical and chemical factors. According to different causes, it can be divided into specific inflammatory lesions and non-specific inflammatory lesions. The former refers to infectious colitis, Ischemic colitis and pseudomembranous colitis, the latter including ulcerative colitis and colonic Crohn's disease. The main clinical manifestations are diarrhea, abdominal pain, mucus and bloody stools, tenesmus, or even constipation, inability to defecate within a few days; often accompanied by weight loss and fatigue, etc....

Claims

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Application Information

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IPC IPC(8): A61L27/12A61L27/18A61L27/20A61L27/38A61L27/50A61L27/54A61L27/56A61L27/58
CPCA61L27/12A61L27/18A61L27/20A61L27/3834A61L27/50A61L27/54A61L27/56A61L27/58C08L5/16C08L87/005C08L71/02
Inventor 向兴力
Owner CHENGDU ZHIA TECH CO LTD
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