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Multifunctional in-situ hybrid scaffold material and preparation method thereof

A scaffold material and multi-functional technology, applied in medical science, prosthesis, tissue regeneration, etc., can solve the problems that the uniform distribution of inorganic particles cannot be well realized, and the mineralization process of natural bone materials cannot be effectively simulated. Efficient killing of tumor cells, good biocompatibility and osteoconductivity, excellent biocompatibility

Inactive Publication Date: 2020-06-09
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the above research is the inorganic particle GdPO 4 and Fe 3 o 4 Directly added to the organic matter, compounded by mechanical mixing to form a multi-phase component scaffold material, which cannot realize the uniform distribution of inorganic particles in the organic matter, so that it cannot effectively simulate the mineralization process of natural bone materials

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] (1) dissolving 1.5g of chitosan in an acetic acid solution with a volume fraction of 2%, magnetic stirring for 30min under 37°C water bath conditions, to obtain chitosan acid solution;

[0035] (2) Under magnetic stirring, each 6 mL of soluble salt solution and phosphate solution with a concentration of 0.069 mol / L are added in the acid solution of step (1) successively, with a time interval of 30 min; wherein the Gd / P molar ratio is n(Gd 3+ ):n(PO 4 3- )=1:1;

[0036] (3) Add 3 mL each of 2mol / L soluble calcium salt solution and 1.2mol / L soluble phosphate solution to the mixed solution of step (2) successively, with a time interval of 30 minutes; wherein the Ca / P molar ratio is n(Ca 2+ ):n(PO 4 3- )=1.67:1;

[0037] (4) According to n(Fe 3+ ):n(Fe 2+ )=1.7:1 ratio, after adding 0.51mL soluble ferrous salt in step (3) and stirring for 30min, then adding 0.3mL soluble ferrous salt and stirring for 30min;

[0038] (5) At room temperature, quickly transfer the homo...

Embodiment 2

[0041] (1) dissolving 2.00g of chitosan in an acetic acid solution with a volume fraction of 2%, and magnetic stirring for 30min under a water bath condition of 37° C., to obtain a chitosan acid solution;

[0042] (2) Under magnetic stirring, each 6 mL of soluble salt solution and phosphate solution with a concentration of 0.069 mol / L are added in the acid solution of step (1) successively, with a time interval of 30 min; wherein the Gd / P molar ratio is n(Gd 3+ ):n(PO 4 3- )=1:1;

[0043] (3) Add 3 mL each of 2mol / L soluble calcium salt solution and 1.2mol / L soluble phosphate solution to the mixed solution of step (2) successively, with a time interval of 30 minutes; wherein the Ca / P molar ratio is n(Ca 2+ ):n(PO 4 3- )=1.67:1;

[0044] (4) According to n(Fe 3+ ):n(Fe 2+ )=1.7:1 ratio, after adding 0.51mL soluble ferrous salt in step (3) and stirring for 30min, then adding 0.3mL soluble ferrous salt and stirring for 30min;

[0045] (5) At room temperature, quickly tran...

Embodiment 3

[0048] (1) Dissolving 2.25g chitosan in an acetic acid solution with a volume fraction of 2%, magnetic stirring for 30min under 37°C water bath conditions, to obtain chitosan acid solution;

[0049] (2) Under magnetic stirring, each 6 mL of soluble salt solution and phosphate solution with a concentration of 0.069 mol / L are added in the acid solution of step (1) successively, with a time interval of 30 min; wherein the Gd / P molar ratio is n(Gd 3+ ):n(PO 4 3- )=1:1;

[0050] (3) Add 3 mL each of 2mol / L soluble calcium salt solution and 1.2mol / L soluble phosphate solution to the mixed solution of step (2) successively, with a time interval of 30 minutes; wherein the Ca / P molar ratio is n(Ca 2+ ):n(PO 4 3- )=1.67:1;

[0051] (4) According to n(Fe 3+ ):n(Fe 2+ )=1.7:1 ratio, after adding 0.51mL soluble ferrous salt in step (3) and stirring for 30min, then adding 0.3mL soluble ferrous salt and stirring for 30min;

[0052] (5) At room temperature, quickly transfer the homoge...

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Abstract

The invention discloses a multifunctional in-situ hybrid scaffold material and a preparation method thereof. A biological mechanism and an in-situ composite technology are adopted, precursor ions of three kinds of particles of inorganic phase phosphate, hydroxyapatite and ferroferric oxide are evenly deposited on a chitosan organic matrix template, and the multiphase hybrid scaffold material withthe magneto-thermal / photo-thermal effect and the in-situ induced osteogenesis function is prepared in a bionic mode. The GdPO4 / CS / HAP / Fe3O4 hybrid scaffold prepared by the preparation method disclosedby the invention integrates the vascularization and osteogenesis of Gd ions, the osteogenesis inductivity of the HAP and the magneto-thermal / photo-thermal effect of the Fe3O4. Aiming at the treatmentof breast cancer bone metastasis diseases and osteosarcoma diseases, the GdPO4 / CS / HAP / Fe3O4 hybrid scaffold is implanted under the condition of an external magnetic field or infrared illumination, sothat the tumor growth can be conveniently inhibited and eliminated, and meanwhile, the in-situ regeneration of defective bone tissues can be induced.

Description

technical field [0001] The invention belongs to the field of composite materials, and in particular relates to a multifunctional in-situ hybrid scaffold material and a preparation method thereof. Background technique [0002] For the treatment of bone diseases such as trauma, bone metastasis and osteosarcoma, bone tissue engineering strategies play a pivotal role, especially how to design and functionalize the scaffold materials of tissue growth carriers so that they can be used in bone diseases. In terms of clinical treatment, it is a hot spot in the scientific research circle to exert special effects. [0003] Nanoscale ferric oxide (Fe 3 o 4 ) as a special inorganic material has been widely used in many fields such as biological targeting materials, microwave absorption, catalysis and separation. Mainly because Fe 3 o 4 Under the stimulation of different external conditions, it will play different roles. Studies have found that electromagnetic fields can directly ac...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/02A61L27/12A61L27/20A61L27/50A61L27/54A61L27/56A61L27/58
CPCA61L27/025A61L27/12A61L27/20A61L27/50A61L27/54A61L27/56A61L27/58A61L2300/102A61L2300/416A61L2430/02C08L5/08
Inventor 赵耀吴明珍丁春梅李建树
Owner SICHUAN UNIV
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