Macromolecular polysaccharide hydrogel and preparation method thereof

A hydrogel and polymer technology, applied in chemical instruments and methods, water pollutants, pharmaceutical formulations, etc., can solve the problem of poor hemostatic efficacy, achieve good growth, simple method, and accelerated hemostasis

Inactive Publication Date: 2020-06-19
广州达康基因技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The currently commonly used clinical methods for treating skin trauma and hemostasis mainly include skin transplantation, medical gelatin sponge, calcium alginate fiber pad, etc., all of which have disadvantages,

Method used

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  • Macromolecular polysaccharide hydrogel and preparation method thereof
  • Macromolecular polysaccharide hydrogel and preparation method thereof
  • Macromolecular polysaccharide hydrogel and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] A preparation method of a drug-adsorbable polymer polysaccharide hydrogel, comprising the following steps:

[0040] Take 0.50 g of pineapple pomace cellulose (PC) and 0.40 g of pectin in a test tube, then add 10 g of [AMIm]Cl, place the test tube in a constant temperature magnetic stirring oil bath, stir and dissolve at 100 ° C, and set the speed to 60 rev / min. After heating, cool to room temperature. Then add isopropanol-water (1:1) solution into the tube and soak until the colloid is precipitated. To fully wash the ionic liquid, the isopropanol-water solution in the test tube was replaced several times during the soaking period. Finally, the colloid is fully soaked and washed with deionized water, and freeze-dried at -80°C to obtain the pineapple pomace cellulose-pectin composite hydrogel (such as figure 1 and figure 2 shown).

[0041] The properties of the hydrogel prepared by the method of the present invention were measured as follows.

[0042] (1) Morpholog...

Embodiment 2

[0055] A preparation method of a drug-adsorbable polymer polysaccharide hydrogel, comprising the following steps:

[0056] Take 0.50 g of bagasse cellulose (SC) and 0.30 g of pectin in a test tube, then add 10 g of [Bdmim]Cl, place the test tube in a constant temperature magnetic stirring oil bath, stir and dissolve at 100 ° C, and set the speed to 50 rev / min. After heating, cool to room temperature. Then add isopropanol-water (1:1) solution into the tube and soak until the colloid is precipitated. To fully wash the ionic liquid, the isopropanol-water solution in the test tube was replaced several times during the soaking period. Finally, the colloid was fully soaked and washed with deionized water, and freeze-dried at -80°C to obtain a bagasse cellulose-pectin composite hydrogel. As in the above experiment, the hydrogel in this experiment has excellent biocompatibility, drug adsorption and drug sustained release properties.

Embodiment 3

[0058] A preparation method of a drug-absorbing polymer polysaccharide hydrogel, such as figure 1 The following steps are shown:

[0059] Take 0.50g of tea cellulose (TC) and 0.10g of pectin in a test tube, then add 10g of [bmim]Cl, place the test tube in a constant temperature magnetic stirring oil bath, stir and dissolve at 100°C, and set the speed to 60 turn / min. After heating, cool to room temperature. Then add isopropanol-water (1:1) solution into the tube and soak until the colloid is precipitated. To fully wash the ionic liquid, the isopropanol-water solution in the test tube was replaced several times during the soaking period. Finally, the colloid was fully soaked and washed with deionized water, and freeze-dried at -80°C to obtain the tea cellulose-pectin composite hydrogel.

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Abstract

The invention discloses a macromolecular polysaccharide hydrogel and a preparation method thereof, wherein the macromolecular polysaccharide hydrogel takes cellulose and pectin as raw materials, the main process is heating, cooling and washing, and the preparation method specifically comprises the following steps: adding an ionic liquid, cross-linking at high temperature, and soaking in an isopropanol aqueous solution until colloid is separated out. According to the invention, the hydrogel is mild in preparation condition, simple in method, few in reagent and free of violent reaction; by usingmethylene blue used as a model drug, the results show that the composite hydrogel material has a good adsorption effect on methylene blue and can be developed into a drug adsorption material; and theresults of cell compatibility experiment show that cells are still fusiform on the hydrogel, are free of lysis, flaking and adherent growth, and are good in growth condition, so that the material hasno obvious cytotoxicity, is a material with good biocompatibility, has a hemostatic effect, and can be developed into a material for medical use.

Description

technical field [0001] The invention relates to the field of medical materials, in particular to a polymer polysaccharide hydrogel and a preparation method thereof. Background technique [0002] Hydrogel is a special dispersion system with a spatial network structure using water as the dispersion medium. It is characterized by the interconnection of colloidal particles or polymers under certain conditions, and the water medium fills the structural voids and fills them. It mainly forms a network structure through chemical bonds, and can also form a network structure through intermolecular forces, physical entanglement, hydrogen bonds or metal complexation. Due to its high elasticity and nonlinear plasticity in its three-dimensional network structure, hydrogel can absorb and retain water. At home and abroad, hydrogels are widely used in many fields such as agriculture, food, medicine, cosmetics, and environmental protection. Such as drug carriers, medical materials, adsorpti...

Claims

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Application Information

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IPC IPC(8): C08J3/24C08J3/075C08L1/02C08L5/06B01J20/24B01J20/28B01J20/30C02F1/28A61L24/08A61L24/00C02F101/38
CPCA61L24/001A61L24/0031A61L24/0042A61L24/08A61L2400/04B01J20/24B01J20/28047C02F1/286C02F2101/308C02F2101/38C08J3/075C08J3/246C08J2301/02C08J2405/06C08L1/02C08L5/06
Inventor 肖扬陈万程
Owner 广州达康基因技术有限公司
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