Warfarin dose prediction method and prediction device

A dose prediction and warfarin technology, applied in the field of warfarin dose prediction, can solve the problem of not being equal, and achieve the effect of ensuring accuracy and accurate warfarin dose

Active Publication Date: 2020-06-19
THE THIRD XIANGYA HOSPITAL OF CENT SOUTH UNIV
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Therefore MLR may not be the most feasible method to accurately predict thes

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  • Warfarin dose prediction method and prediction device
  • Warfarin dose prediction method and prediction device
  • Warfarin dose prediction method and prediction device

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[0053] In order to make the purpose, technical solution and advantages of the present application clearer, the present application will be further described in detail below in conjunction with the accompanying drawings and embodiments. It should be understood that the specific embodiments described here are only used to explain the present application, and are not intended to limit the present application.

[0054] The warfarin dose prediction method provided by this application can be applied to such as figure 1 shown in the application environment. Wherein, the user terminal 102 communicates with the server 104 through the network. The server 104 may receive the user information sent by the user terminal 102, and input the user information into the warfarin dose prediction model to obtain the warfarin dose corresponding to the user information. Wherein, the generation method of the warfarin dose prediction model may include: the server 104 extracts a sample set from the da...

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Abstract

The invention discloses a warfarin dose prediction method and prediction device, and the method comprises the steps of: extracting a sample set from a database, carrying out the normalization of the sample set, and dividing the normalized sample set into a plurality of groups; sequentially selecting one group as a first verification set and the rest groups as a training set, constructing a singlemodel according to the training set and a preset algorithm, verifying the single model through the currently selected first verification set to obtain an error of the single model, and, according to the error corresponding to the same preset algorithm, calculating the precision corresponding to the preset algorithm; selecting the algorithm with the precision meeting the requirement as the optimalalgorithm; adjusting the parameters of the optimal algorithm through grid search; training according to the sample set and the optimal algorithm obtained after parameter adjustment to obtain a warfarin dose prediction model; and acquiring user information, and inputting the user information into the warfarin dose prediction model to obtain a warfarin dose corresponding to the user information. Byadopting the method, the prediction accuracy can be improved.

Description

technical field [0001] The invention relates to a warfarin dose prediction method and a prediction device, belonging to the technical field of drug detection. Background technique [0002] Warfarin is a coumarin oral anticoagulant synthesized by the University of Wisconsin in the United States in the 1940s. It can block the production of reduced vitamin K by inhibiting the activity of vitamin K epoxide reductase, thereby inhibiting Vitamin K-dependent activation of coagulation factors II, VII, IX, and X plays an anticoagulant role. Warfarin is the most commonly used oral anticoagulant drug and has been on the market for more than 60 years. It is widely used clinically in atrial fibrillation (AF), deep vein thrombosis (deep vein thrombosis DVT) and other diseases, and can effectively reduce the risk of such patients. risk of thromboembolism. In 2010, warfarin was used in more than 25 million prescriptions in the United States, which is equivalent to 0.5-1.5% of the populati...

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Application Information

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IPC IPC(8): G16C20/50G16C20/70G16H70/40
CPCG16C20/50G16C20/70G16H70/40
Inventor 阳国平裴奇郭成贤况赟
Owner THE THIRD XIANGYA HOSPITAL OF CENT SOUTH UNIV
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