Film-coated bioceramic artificial bone and preparation method

A technology of bioceramics and artificial bone, applied in the medical field, can solve the problems of high requirements for operation and postoperative management of source surgeons, increased patient pain and treatment time, and limited sources, so as to avoid bone nonunion and improve cell implantation Efficiency and adhesion ability, the effect of avoiding repair obstacles

Inactive Publication Date: 2020-06-23
西安点云生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the above methods have certain limitations: autologous bone transplantation is mainly suitable for defects below 5 cm and its source is limited; allogeneic or heterogeneous bone transplantation is also difficult to be widely recognized due to rejection and infection factors; vascularized fibular bone transplantation is suitable for the treatment of large segments Bo

Method used

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  • Film-coated bioceramic artificial bone and preparation method
  • Film-coated bioceramic artificial bone and preparation method
  • Film-coated bioceramic artificial bone and preparation method

Examples

Experimental program
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preparation example Construction

[0039] The raw materials for the preparation of bioceramic artificial bone include bioceramic powder and binder, and the bioceramic powder is hydroxyapatite (HA), β-tricalcium phosphate (β-TCP), calcium carbonate, calcium silicate and calcium sulfate. a mixture of one or more. As bioactive ceramics, hydroxyapatite and β-tricalcium phosphate are similar in structure and composition to minerals in natural bone matrix, and are good biomimetic materials with good biocompatibility, bioactivity, bone Inductive and osteoconductive, are widely used in bone repair materials.

[0040] The binder is preferably polyvinyl alcohol or collagen. Polyvinyl alcohol is a water-soluble polymer, which can co-dissolve with silk fibroin in water to form a mixed system.

[0041] The raw materials for the preparation of the film include silk fibroin, and can also include biological macromolecular substances, and the biological macromolecular substances are chitosan, polylactic acid, gelatin, hyaluro...

Embodiment 1

[0058] Example 1: see figure 1

[0059] (1) Preparation of adhesive: 8g of polyvinyl alcohol and 92g of water for injection were prepared into a polyvinyl alcohol aqueous solution with a mass fraction of 8%, placed in a solvent bottle with a lid, heated and swollen in a water bath at 60°C for 4h, and then magnetically heated at 95°C. Stir at 160r / min for 2h in the stirrer to make it completely dissolved to form a homogeneous solution;

[0060] (2) Preparation of printing paste: Mix hydroxyapatite and β-tricalcium phosphate in a mass ratio of 3:2 to form a bioceramic powder, and then mix the bioceramic powder and adhesive in a mass ratio of 1:1.05, Place it in a homogenizer and mix at 1800r / min for 8 minutes to form a uniform printing paste, and then put the printing paste into a barrel for use.

[0061] (3) 3D model of artificial bone: Obtain CT or MRI or X-ray of the patient's bone defect, use 3D reconstruction software to process the data, obtain a prototype bone model of ...

Embodiment 2

[0071] Example 2: see figure 2

[0072] (1) Preparation of adhesive: 10g of polyvinyl alcohol and 90g of water for injection were prepared into a polyvinyl alcohol aqueous solution with a mass fraction of 10%, placed in a solvent bottle with a lid, heated and swollen in a water bath at 60°C for 4h, and then magnetically heated at 95°C. Stir at 160r / min for 2h in the stirrer to make it completely dissolved to form a homogeneous solution;

[0073] (2) Preparation of printing paste: Mix β-tricalcium phosphate and adhesive at a mass ratio of 1:0.8, and place them in a homogenizer at a speed of 1800 r / min for 8 minutes to form a uniform printing paste. The print paste is then loaded into the cartridge.

[0074] (3) 3D model of artificial bone: Obtain CT or MRI or X-ray of the patient's bone defect, use 3D reconstruction software to process the data, obtain a prototype bone model of the host, and use 3D modeling software to design a model suitable for the anatomical structure of ...

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Abstract

The present invention provides a film-coated bioceramic artificial bone and a preparation method. The film-coated bioceramic artificial bone comprises a bioceramic artificial bone and a coating film wrapped on an outer surface of the bioceramic artificial bone; and a raw material for preparing the coating film is silk fibroin. The coating film on the artificial bone can effectively improve cell planting efficiency and adhesion ability of the artificial bone, at the same time avoids a bone nonunion phenomenon caused by periosteum defects, and effectively improves an osteogenic repair rate. Thecoating film is prepared by using the silk fibroin, the silk fibroin has no toxic effects on human body and can be hydrolyzed and degraded by proteases, degradation products have no toxic and side effects on tissues, and after the film-coated bioceramic artificial bone is used, no secondary surgery taking-out is needed, and pains of patients are reduced.

Description

technical field [0001] The invention belongs to the field of medical technology, and relates to a film-coated bioceramic artificial bone and a preparation method. Background technique [0002] At present, the treatment methods for bone defects mainly include autologous bone graft, allogeneic or xenograft bone graft, and vascularized fibula graft. However, the above methods all have certain limitations: autologous bone transplantation is mainly suitable for defects below 5 cm and its sources are limited; allogeneic or xenograft bone transplantation is also difficult to be widely recognized due to rejection and infection factors; vascularized fibula transplantation is suitable for the treatment of large segments Bone defect, but it has higher requirements on its source, operator's operation and postoperative management. [0003] Fracture healing integrates the synergistic effects of inflammatory cells, stem cells, osteoblasts, osteoclasts, and growth factors. In the process o...

Claims

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Application Information

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IPC IPC(8): A61L27/10A61L27/12A61L27/34A61L27/28A61L27/50A61L27/54A61L27/58B33Y10/00B33Y70/10B33Y80/00A61F2/28D04H1/728
CPCA61F2/28A61F2002/30948A61F2002/30985A61L27/10A61L27/12A61L27/28A61L27/34A61L27/50A61L27/54A61L27/58A61L2300/236A61L2300/402A61L2300/404A61L2300/41A61L2300/412A61L2300/42A61L2400/04A61L2400/18A61L2420/02A61L2420/06A61L2430/02B33Y10/00B33Y70/00B33Y80/00D04H1/728C08L89/00C08L5/08C08L67/04
Inventor 曾庆丰魏静益明星
Owner 西安点云生物科技有限公司
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