Boron-containing compound as well as preparation method and application thereof
A boron compound and compound technology, which can be used in chemical instruments and methods, compounds containing elements of Group 3/13 of the periodic table, organic chemistry, etc., and can solve problems such as disparity
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Embodiment 1
[0109] Embodiment 1: the synthesis of compound H2:
[0110]
[0111]In a 250ml three-neck flask, under the protection of nitrogen, add 0.01mol intermediate G1, 0.012mol tert-butyllithium and 150ml tert-butylbenzene, stir and mix, heat to 60°C, stir and react for 2h; then naturally cool to room temperature, drop Add 0.012molBBr 3 and 0.05mol diisopropylethylamine, stirred and reacted at room temperature for 1h, and the plate was sampled, showing that no intermediate G1 remained, and the reaction was complete; adding water and dichloromethane for extraction and liquid separation; taking the organic phase, adding anhydrous magnesium sulfate Water was removed, filtered, and the filtrate was rotary evaporated under reduced pressure (-0.09MPa, 25°C), and passed through a neutral silica gel column to obtain the target product, with a HPLC purity of 99.1% and a yield of 45.7%;
[0112] Elemental analysis structure (molecular formula C 41 h 41 B 2 NO): Theoretical C, 84.12; H, 7...
Embodiment 2
[0113] Embodiment 2: the synthesis of compound H4:
[0114]
[0115] The preparation method of compound H4 is the same as that of Example 1, except that intermediate G1 is replaced by intermediate G2.
[0116] Elemental analysis structure (molecular formula C 36 h 24 B 2 N 2 ): theoretical value C, 85.42; H, 4.78; B, 4.27; N, 5.53; test value: C, 85.43; H, 4.76; B, 4.28; N, 5.54. ESI-MS(m / z)(M + ): The theoretical value is 506.21, and the measured value is 506.22.
Embodiment 3
[0117] Embodiment 3: the synthesis of compound H13:
[0118]
[0119] In a 250ml three-necked flask, under the protection of nitrogen, add 0.01mol of intermediate G3, 0.024mol of tert-butyllithium and 150ml of tert-butylbenzene, stir and mix, heat to 60°C, stir and react for 2h; then naturally cool to room temperature, drop Add 0.024molBBr 3 and 0.1mol of diisopropylethylamine, stirred and reacted at room temperature for 1h, and the plate was sampled and showed that no intermediate G3 remained, and the reaction was complete; adding water and dichloromethane for extraction and liquid separation; taking the organic phase, adding anhydrous magnesium sulfate Water was removed, filtered, and the filtrate was subjected to vacuum rotary evaporation (-0.09MPa, 25° C.), and passed through a neutral silica gel column to obtain the target product with a HPLC purity of 99.2% and a yield of 41.8%;
[0120] Elemental analysis structure (molecular formula C 30 h 17 B 2 NO 2 ): theore...
PUM
Property | Measurement | Unit |
---|---|---|
Thickness | aaaaa | aaaaa |
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com