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Dopamine gel based micro-needle array and preparation and application thereof

A technology of dopamine gel and microneedle array, which is applied in the field of biomedical materials, can solve problems such as weak adhesion, limited application site, and shedding, so as to achieve long-term drug administration and drug release, avoid bacterial infection, The effect of autonomous drug delivery

Active Publication Date: 2020-07-10
NANJING DRUM TOWER HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Existing micro-needles do not have strong adhesion to the skin, and are easy to fall off from the skin. During use, it is necessary to use applicators, medical tapes, etc. to help adhere, which not only brings inconvenience to use, but also causes skin discomfort
In addition, the function of existing microneedles is relatively single, and the application site is relatively limited

Method used

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  • Dopamine gel based micro-needle array and preparation and application thereof
  • Dopamine gel based micro-needle array and preparation and application thereof
  • Dopamine gel based micro-needle array and preparation and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0028] This embodiment provides a dopamine gel-based polyethylene glycol diacrylate-sodium alginate microneedle array, the preparation method of which comprises the following steps:

[0029] Step 1, curing of the microneedle tip.

[0030] Prepare a mixed aqueous solution of 25% (v / v) polyethylene glycol diacrylate, 3% (w / v) sodium alginate and 1% (v / v) 2-hydroxy-2-methylpropiophenone, that is, the needle tip raw material solution. Add the needle tip raw material solution dropwise on the surface of the template, and treat with vacuum for 10 minutes to ensure that the mixed aqueous solution is fully filled in the template. Then, use a pipette to suck away the mixed hydrogel that is not filled to the tip of the template. UV irradiating the template filled with the mixed aqueous solution for 18s to obtain cured microneedle tips.

[0031] Step 2, gelation of the microneedle base.

[0032] Dissolve 45 mg of dopamine monomer, 150 mg of gelatin, and 25.5 mg of sodium periodate in ...

Embodiment 2

[0040] This embodiment provides a methacrylate gelatin-carboxymethylcellulose sodium microneedle array based on dopamine gel, and its preparation method comprises the following steps:

[0041] Step 1, curing of the microneedle tip.

[0042]Configure a mixed aqueous solution of 20% (w / v) methacrylate gelatin, 2% (w / v) sodium carboxymethylcellulose and 1% (v / v) 2-hydroxyl-2-methylpropiophenone, namely Needle tip stock solution. The needle point raw material solution was added dropwise on the surface of the template, and the vacuum treatment was performed for 8 minutes to ensure that the mixed aqueous solution was fully filled in the template. Then, use a pipette to suck away the mixed hydrogel that is not filled to the tip of the template. The template filled with the mixed aqueous solution was irradiated with ultraviolet light for 30 seconds to obtain cured microneedle tips.

[0043] Step 2, gelation of the microneedle base.

[0044] Dissolve 50 mg of dopamine monomer, 150 ...

Embodiment 3

[0046] This embodiment provides a dopamine gel-based methacrylate gelatin-sodium alginate microneedle array, the preparation method of which comprises the following steps:

[0047] Step 1, curing of the microneedle tip.

[0048] Prepare a mixed aqueous solution of 20% (w / v) methacrylate gelatin, 4% (w / v) sodium alginate and 1% (v / v) 2-hydroxy-2-methylpropiophenone, that is, the needle tip raw material solution . The needle point raw material solution was added dropwise on the surface of the template, and the vacuum treatment was performed for 8 minutes to ensure that the mixed aqueous solution was fully filled in the template. Then, use a pipette to suck away the mixed hydrogel that is not filled to the tip of the template. The template filled with the mixed aqueous solution was irradiated with ultraviolet light for 30 seconds to obtain cured microneedle tips.

[0049] Step 2, gelation of the microneedle base.

[0050] Dissolve 15 mg of dopamine monomer, 150 mg of gelatin,...

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Abstract

The invention discloses a dopamine gel based micro-needle array and preparation and application thereof. The micro-needle array comprises needle tips and a base, wherein the base is mixed gel preparedfrom base raw materials including dopamine and gelatin. The micro-needle array is prepared stepwise by filling a micro-needle template with the needle tip raw material solution, and solidifying the needle tip raw material solution, and filling the micro-needle template with an adhesive base. The prepared micro-needle array is strong in adhesion and can be firmly attached to different tissue parts; and the needle tips and the base of the micro-needle array can carry various medicines or antibacterial substances for bacteria and infection resistance, transdermal drug delivery and disease treatment. The micro-needle array provided by the invention also has the characteristics of being safe, universal and multifunctional, and is applicable to the technical fields of wearable diagnosis and treatment systems and the like.

Description

technical field [0001] The invention belongs to the field of biomedical materials and relates to a microneedle array, in particular to a dopamine gel-based microneedle array and its preparation and application. Background technique [0002] Microneedles refer to needle tips or arrays composed of them in the size of micrometers. Microneedles can penetrate the stratum corneum of the skin and leave micron-scale channels, which can enhance the penetration and absorption of drugs by the skin; at the same time, the microneedles avoid the capillaries and nerve fibers of the skin, leaving Small wounds can heal quickly. Therefore, microneedling is a minimally invasive, painless, safe and effective method. [0003] After the development in recent years, the types of microneedles have become more and more abundant, and have been widely used in many fields. Because microneedles can directly deliver drugs to diseased parts, it has outstanding and irreplaceable value in the treatment o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K47/02A61K47/34A61K47/42A61M37/00
CPCA61K9/0021A61K47/02A61K47/34A61K47/42A61M37/0015A61M2037/0046A61M2037/0053
Inventor 赵远锦张筱萱王月桐
Owner NANJING DRUM TOWER HOSPITAL
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