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Liver-protecting and intestine-protecting immunopotentiation composition for freshwater fish, and preparation and application for liver-protecting and intestine-protecting immunopotentiation composition

An immune-enhancing, freshwater fish technology, applied in applications, drug combinations, medical preparations containing active ingredients, etc., can solve problems such as the irregular use and abuse of drugs, the destruction of the ecological balance of waters, and the troubled freshwater fish aquaculture industry. The effect of promoting the growth of fish, removing bacteria and toxins, and protecting the intestinal mucosal barrier

Active Publication Date: 2020-07-10
FRESHWATER FISHERIES RES INSITUTE OF JIANGSUPROVINCE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] In recent years, with the rapid development of intensive farming, aquaculture, especially the farming of freshwater fish, has encountered a series of problems and difficulties: on the one hand, the problem of fish diseases caused by intensive farming has become increasingly prominent, and the aquaculture water The environment is also deteriorating day by day; on the other hand, fish body metabolism is becoming increasingly disordered and immunity is declining in harsh environments, and the irregular use and abuse of drugs further destroys the ecological balance of waters
[0003] Traditionally, the treatment and prevention of freshwater fish diseases mainly rely on antibiotics and chemical drugs, but the abuse of these drugs is likely to cause many negative effects such as environmental pollution, drug residues, drug resistance of pathogenic microorganisms, immunosuppression, and damage to the micro-ecological balance of the body, causing serious troubles freshwater fish farming

Method used

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  • Liver-protecting and intestine-protecting immunopotentiation composition for freshwater fish, and preparation and application for liver-protecting and intestine-protecting immunopotentiation composition
  • Liver-protecting and intestine-protecting immunopotentiation composition for freshwater fish, and preparation and application for liver-protecting and intestine-protecting immunopotentiation composition
  • Liver-protecting and intestine-protecting immunopotentiation composition for freshwater fish, and preparation and application for liver-protecting and intestine-protecting immunopotentiation composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Take by weighing 20 parts by weight of Andrographis paniculata, 20 parts by weight of Folium Radix Folium L., 10 parts by weight of Polygonum capericum, 10 parts by weight of rhubarb, 10 parts by weight of gallnut, 10 parts by weight of taurine, and 20 parts by weight of diatomaceous earth; Coarse pulverization, and then wall-breaking pulverization by an ultrafine pulverizer at -20°C, passing through a 300-mesh sieve, and fully mixing in a mixer to prepare a compound Chinese herbal medicine liver-protecting and intestinal-protecting immune-enhancing composition.

Embodiment 2

[0032] Freshwater fish mainly rely on their non-specific immune system to protect themselves. The levels of parameters such as lysozyme, immunoglobulin M, superoxide dismutase, malondialdehyde and total antioxidant capacity are directly related to the immune status of the body; The activity of aspartate aminotransferase and alanine aminotransferase can reflect the health status of the liver; the health of the intestinal tract can be tested by the activity of digestive enzymes such as trypsin, lipase and amylase. Therefore, the present embodiment evaluates the immunity and body health of crucian carp by the above indicators.

[0033] Growth test: Randomly select 9 crucian carp ponds in the Huangsha Port area of ​​Sheyang, Jiangsu Province (the pond size, crucian carp stocking density and management mode are all the same), and randomly group them:

[0034] Control group A (feeding basic commodity materials);

[0035] Control group B (add 0.5% Andrographis paniculata in the basi...

Embodiment 3

[0048] Challenge test: after the 4-month growth test of each group of crucian carp in Example 2, fast for 24 hours, each pond selects crucian carp with the same specification to carry out the Aeromonas hydrophila infection test.

[0049] The challenge test was carried out in a plastic box (1.0m×0.4m×0.4m), with three repetitions in each group and 30 fish in each repetition. Aeromonas hydrophila was provided by the Fish Disease Laboratory of Jiangsu Freshwater Fisheries Research Institute, diluted with sterile saline to a final concentration of about 5×10 7 cells / mL, according to the intraperitoneal injection of 1.0 mL of bacterial liquid per 100 g of fish, observe the physiological activities of the fish after intraperitoneal injection of bacterial liquid, and count the cumulative mortality of 9 groups of fish at 0h, 12h, 24h, 48h, and 96h after the challenge. The results are shown in Table 2.

[0050] Table 2

[0051]

[0052]

[0053] The results showed that after th...

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PUM

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Abstract

The invention discloses a liver-protecting and intestine-protecting immunopotentiation composition for freshwater fish. The liver-protecting and intestine-protecting immunopotentiation composition comprises the following raw materials in parts by weight: 15 to 27 parts by weight of herba andrographitis, 18 to 22 parts of folium isatidis, 10 to 15 parts of polygonum hydropiper, 8 to 12 parts of radix et rhizoma rhei and 8 to 12 parts of gallnut. The invention further discloses a preparation method and an application for the composition. The composition provided by the invention has the effectsof resisting bacteria, scavenging free radicals, clearing away heat and toxic materials, preventing and treating enteritis and the like, and can effectively improve the immunity of the freshwater fishand guarantee the body health of the freshwater fish.

Description

technical field [0001] The invention relates to the technical field of aquaculture, and more specifically relates to a liver-protecting, intestinal-protecting and immune-enhancing composition for freshwater fish, as well as its preparation and application. Background technique [0002] In recent years, with the rapid development of intensive farming, aquaculture, especially the farming of freshwater fish, has encountered a series of problems and difficulties: on the one hand, the problem of fish diseases caused by intensive farming has become increasingly prominent, and the aquaculture water The environment is also deteriorating day by day; on the other hand, fish body metabolism is becoming increasingly disordered and immunity is declining in harsh environments, and the irregular use and abuse of drugs further destroys the ecological balance of waters. [0003] Traditionally, the treatment and prevention of freshwater fish diseases mainly rely on antibiotics and chemical dr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/704A61K36/708A61K36/855A61P1/00A61P1/16A61P31/04A61P37/04A23K10/30A23K20/10A23K20/28A23K50/80A61K31/185A61K33/00A61K35/64
CPCA61K36/19A61K36/855A61K36/704A61K36/315A61K36/195A61K36/708A61K35/64A61K31/185A61K33/00A61P1/16A61P1/00A61P31/04A61P37/04A23K10/30A23K20/28A23K20/10A23K50/80A61K2300/00Y02A40/818A23K20/105A61K36/22A61K31/145
Inventor 万金娟薛晖袁圣夏爱军赵彦华沈美芳
Owner FRESHWATER FISHERIES RES INSITUTE OF JIANGSUPROVINCE
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