Pure titanium implant provided with cobalt-doped coating and preparation method of pure titanium implant

A technology of implants and pure titanium, which is applied in coatings, prostheses, pharmaceutical formulations, etc., can solve the problems of insufficient osseointegration on the surface of implants, and achieve the effects of preventing inflammation, uniform coating thickness, and promoting differentiation and proliferation

Active Publication Date: 2020-07-10
THE STOMATOLOGIAL HOSPITAL OF ZHEJIANG UNIV SCHOOL OF MEDICINE
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  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, current studies have shown that the osseointegration ability of the im

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  • Pure titanium implant provided with cobalt-doped coating and preparation method of pure titanium implant
  • Pure titanium implant provided with cobalt-doped coating and preparation method of pure titanium implant

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[0024] The invention provides a method for preparing a pure titanium implant with a cobalt-doped coating, comprising the following steps:

[0025] (1) The surface of the pure titanium implant is sequentially polished, sandblasted, cleaned and dried to obtain a pretreated pure titanium implant;

[0026] (2) acid-etching the surface of the pretreated pure titanium implant to obtain an acid-etched pure titanium implant;

[0027] (3) Using the acid-etched pure titanium implant as the cathode, a two-electrode system is used for electrochemical deposition in a cobalt-containing electrolyte, and a cobalt-doped coating is formed on the surface of the pure titanium implant to obtain a pure titanium implant with a cobalt-doped coating body; the cobalt-containing electrolyte consists of CaCl 2 , NH 4 h 2 PO 4 , NaCl, CoCl 2 Prepared with water raw materials.

[0028] In the present invention, the surface of the pure titanium implant is sequentially polished, sand blasted, cleaned a...

Embodiment 1

[0044] (1) The pure titanium sheet is polished with sandpaper of 320 mesh, 600 mesh, 800 mesh, and 1000 mesh in order from small to large. After the grinding is smooth and uniform, the large particle emery is used for sandblasting under the pressure of 4MPa until the surface of the titanium sheet is uniform. No obvious reflection; ultrasonically clean the sandblasted titanium sheet in acetone solution for 15 minutes, repeat 3 times, then ultrasonically clean in 75% ethanol and deionized water for 15 minutes each, and dry in an oven;

[0045] (2) Use 0.09mol / L nitric acid, 0.11mol / L hydrofluoric acid and distilled water to prepare the first acid etching solution (4:2:1000 by volume), and immerse the completely dried in step (1). The surface of the titanium sheet is placed at room temperature for the first acid etching for 10 minutes. After the specified reaction time is reached, the solution in the glass dish is discarded, and the surface of the titanium sheet is rinsed with a l...

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Abstract

The invention relates to the technical field of oral implantology and provides a pure titanium implant provided with a cobalt-doped coating and a preparation method of the pure titanium implant. According to the preparation method, firstly, polishing, sand-blasting treatment, cleaning and drying are sequentially performed on the surface of the pure titanium implant; then, acid etching is performedon the pretreated pure titanium implant; and next, the cobalt-doped coating is deposited on the surface of the acid-etched pure titanium implant through electrochemical deposition, and the pure titanium implant provided with the cobalt-doped coating is obtained. Through the method provided in the invention, the electrochemical deposition method is utilized to successfully dope cobalt ions and obtain the coating provided with micro-nano structure and morphology, so that the pure titanium implant provided with a novel surface is obtained; doping of the cobalt ions can promote blood vessel generation; and in the implant-bone contact forming process, the cobalt-doped coating also can accelerate differentiation and proliferation of osteoblasts, so that generation of new bone tissue is promoted.

Description

technical field [0001] The invention relates to the field of oral implant technology, in particular to a pure titanium implant with a cobalt-doped coating and a preparation method thereof. Background technique [0002] Osteoporosis is a systemic disease, the most obvious feature of which is the reduction of bone mass, bone density and destruction of bone microstructure, resulting in increased bone fragility and high susceptibility to fracture in patients. Currently, approximately 200 million people worldwide suffer from osteoporosis. The pathological factors leading to osteoporosis can be simply summarized as the destruction of bone balance established by osteoclasts and osteoblasts, and the bone depression formed by osteoclast resorption is not filled by new bone formed by osteoblasts, that is, new bone formation. A negative balance occurs when there is less bone mass than can be resorbed. Osteoporosis can lead to the destruction of bone tissue around the teeth, which mak...

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Application Information

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IPC IPC(8): C25D9/08C25D3/12C25D5/38C25D21/12C23F1/26A61L27/06A61L27/30A61L27/32A61L27/50A61L27/54
CPCA61L27/06A61L27/306A61L27/32A61L27/50A61L27/54A61L2300/102A61L2300/404A61L2400/12A61L2400/18A61L2420/02A61L2420/06A61L2430/12C23F1/26C25D3/12C25D5/38C25D9/08C25D21/12
Inventor 杨国利黄廷贲俞舟俞琼姜治伟
Owner THE STOMATOLOGIAL HOSPITAL OF ZHEJIANG UNIV SCHOOL OF MEDICINE
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