Method and device for measuring placental blood flow by utilizing flow-velocity compensated and non-compensated diffusion magnetic resonance

A placental blood, magnetic resonance technology, applied in the direction of blood flow measurement, diagnostic recording/measurement, application, etc., can solve the problem that blood flow velocity does not have an accurate measurement method.

Active Publication Date: 2020-07-14
ZHEJIANG UNIV
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  • Abstract
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  • Claims
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Problems solved by technology

[0003] However, the conventional IVIM can only make a general calculation of the proportion and diffusivity of microcirculatory blood, and there is no accurate measurement method for blood flow velocity.

Method used

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  • Method and device for measuring placental blood flow by utilizing flow-velocity compensated and non-compensated diffusion magnetic resonance
  • Method and device for measuring placental blood flow by utilizing flow-velocity compensated and non-compensated diffusion magnetic resonance
  • Method and device for measuring placental blood flow by utilizing flow-velocity compensated and non-compensated diffusion magnetic resonance

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Embodiment

[0064] This experiment was performed on a 1.5T MAGNETOM Aera magnetic resonance imaging system (Siemens Healthcare, Erlangen, Germany) with diffusion-weighted sequences of FC and NC gradients, performed with an 18-channel body coil. With patient consent and approval by the local institutional review board, 40 pregnant women (22.7 to 38 weeks' gestation) were included in the study. The IVIM data is acquired by FC and NC sequences, and its acquisition field of view is 350×350 mm 2 , the resolution within the slice is 2.73×2.73mm 2 , slice thickness 6mm, 10 slices along the sagittal direction, using 9 b values ​​(10-600s / mm 2 ), 6 diffusion directions, one signal average, GRAPPA with an acceleration factor of 2, and the scan times for the FC and NC sequences were 2.5 minutes each.

[0065] The IVIM image first performs motion correction between each diffusion-weighted image through multiple iterative affine registration methods, and uses mutual information as a cost function. T...

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Abstract

The invention discloses a method and device for measuring placental blood flow by utilizing flow-velocity compensated and non-compensated diffusion magnetic resonance. The method includes the following steps: based on a spin echo diffusion-weighted sequence, constructing a flow-velocity compensated (FC) diffusion-weighted sequence through bipolar gradient fields with same polarity; using the bipolar gradient fields with polar mirror symmetry to construct a non flow-velocity compensated (NC) diffusion-weighted sequence; respectively adopting the FC and NC sequences to measure the intra-voxel incoherent motion (IVIM) signals with multiple b values of placenta of pregnant women; and establishing an FC-NC joint model, and performing fitting to estimate the proportion and flow velocity of ballistic type blood microcirculation flow and the diffusion rate of tissue water. Compared with clinically and conventionally used IVIM imaging modes, the method can refine the ballistic type components and diffusion type components in microcirculation blood flow; and therefore, novel IVIM quantitative indexes can be provided, and the effects of the two kinds of microcirculation in placentas in a fetal-placental perfusion system can be quantitatively explained.

Description

technical field [0001] The present application relates to the field of magnetic resonance technology, in particular to the field of diffusion magnetic resonance imaging sequence and modeling. Background technique [0002] Intravoxel incoherent imaging (IVIM) technology based on diffusion magnetic resonance can non-invasively reveal information about microcirculatory blood flow in capillaries and small blood vessels in biological tissues, and provide quantitative evaluation indicators, such as relative blood flow in microcirculation. The proportion of tissue water (f), the diffusivity of microcirculation (D*), and the diffusivity of tissue water (D). IVIM technology has been widely used in the evaluation of microcirculation perfusion status of human tissues and organs, including brain, liver, kidney, breast, placenta, etc. Among them, the application of IVIM in placental imaging has attracted more and more attention, because the perfusion of the placenta cannot be obtained b...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/055A61B5/026A61B5/00
CPCA61B5/026A61B5/055A61B5/4318
Inventor 吴丹蒋玲孙陶陶钱朝霞孙毅张祎
Owner ZHEJIANG UNIV
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