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Anti-adhesive low-compression set polyurethane foam material for nasal hemostasis and preparation method of polyurethane foam material

A polyurethane foam and anti-adhesion technology is applied in the field of nasal medical consumables and its preparation, which can solve the problems of poor storage stability and inconvenient use, and achieve the effects of preventing adhesion, alleviating pain, and avoiding a decrease in comfort.

Active Publication Date: 2020-07-17
优尔爱(常州)医疗科技有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Poor storage stability and inconvenient use

Method used

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  • Anti-adhesive low-compression set polyurethane foam material for nasal hemostasis and preparation method of polyurethane foam material
  • Anti-adhesive low-compression set polyurethane foam material for nasal hemostasis and preparation method of polyurethane foam material
  • Anti-adhesive low-compression set polyurethane foam material for nasal hemostasis and preparation method of polyurethane foam material

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Experimental program
Comparison scheme
Effect test

Embodiment 1-6

[0056] (1) Preparation of component A polyurethane:

[0057] A. Accurately weigh the fluorine-containing polyether polyol into the three-necked flask according to the addition amount of each component listed in Table 1, start stirring, and raise the temperature to 110°C, vacuumize (-0.098MPa), 2h, carry out Raw materials are refined and dehydrated.

[0058] B. Stop heating and cool down to 50°C, weigh and add hydrogenated diphenylmethane diisocyanate according to the addition amount in Table 1, and start stirring and mixing.

[0059] C. Heat up to 80-95°C and react for 3 hours.

[0060] D. Cool down to 50°C, stand still for 8 hours, and use as component A.

[0061] (2) Preparation of component B crosslinking agent:

[0062] A. According to component B listed in Table 1, add 1,4 butanediol, pure water, foam stabilizer silicone oil, stannous octoate catalyst and triethylenediamine catalyst in sequence.

[0063] B. Start stirring, raise the temperature to 50°C, and mix for 3 ...

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Abstract

The invention relates to an anti-adhesive low-compression set polyurethane foam material for nasal hemostasis and a preparation method of the polyurethane foam material, and is used for nasal cavity medical surgery. According to the method, the molecular structure of a polyurethane foaming body is designed, a fluorine-containing polyether polyol is used, wherein hard-segment 1,4-butanediol is selected preferably, so that the polyurethane foam material with low compression set and a specific compression elastic modulus is obtained, and after the surface is coated with a coating, the medical nasal hemostatic foam is obtained. The polyurethane foam material can avoid the problem of a reduced degree of comfort caused by excessive nasal compression while effectively stopping bleeding, and alleviate the pain after packing; and the nasal hemostatic cotton provided by the invention has a hydrophobic coating, and has the effects of stopping bleeding, promoting wound healing and preventing adhesion in the healing process of nasal cavity wounds, so that the risk of secondary trauma when the nasal cavity hemostatic cotton is taken out is reduced.

Description

technical field [0001] The invention relates to a nasal medical consumable and a preparation method thereof, in particular to a low-pressure variable polyurethane foam material for anti-adhesion nasal cavity hemostasis and a preparation method thereof. Background technique [0002] Nasal hemostatic cotton is a commonly used medical material. It is widely used in the hemostasis of nasal surgery wounds and the treatment of emergency epistaxis. In the prior art, nasal hemostatic cotton with different materials and structural characteristics has been developed according to its medical needs, as listed below. [0003] Patent 201320771266.7 "Nasal Hemostatic Cotton" belongs to a nasal hemostatic cotton in the field of medical devices. The nasal hemostatic cotton is formed by wrapping a hemostatic sleeve on a columnar support. The hemostatic sleeve is an alginate coating sleeve or an alginate film Cover or alginate non-woven cover. But in practical application of this utility mo...

Claims

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Application Information

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IPC IPC(8): A61L24/04A61L24/00A61B17/12C08G18/75C08G18/66C08G18/50C08G18/32C08J9/36C08G101/00
CPCA61L24/046A61L24/0036A61L24/001A61B17/1204C08G18/758C08G18/6674C08G18/5015C08J9/365A61L2400/04A61B2017/12004A61B2017/00526A61B2017/00831C08J2375/08C08J2475/04C08G2101/00C08L75/08C08L75/04
Inventor 张均熊墨勇姜志国熊一男万辉王爽
Owner 优尔爱(常州)医疗科技有限公司
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