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Mitochondrial protective agent and application thereof

A technology of mitochondrial protection and protective agent, which can be used in nervous system cells, microorganisms, biochemical equipment and methods, etc., can solve problems such as destruction, reduction of ATP generation and electron transport chain effect

Active Publication Date: 2020-07-24
尚禾粒线体生物科技(深圳)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, under the stimulation of ultraviolet light, there is a certain damage to the mitochondria, especially the damage to the mitochondria of retinal cells, which reduces the generation of ATP and the role of the electron transport chain.

Method used

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  • Mitochondrial protective agent and application thereof
  • Mitochondrial protective agent and application thereof
  • Mitochondrial protective agent and application thereof

Examples

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preparation example Construction

[0020] The preparation method of the rice bran extract of the present invention preferably comprises: mixing rice bran with ddH 2 O was mixed according to the mass volume ratio of 1g: 10mL and boiled for 3 hours, cooled to 18-25°C and centrifuged, and the supernatant was frozen at -80°C for more than 12 hours, and then freeze-dried to obtain the rice bran extract. The centrifugal force of the centrifugation in the present invention is preferably 8000g, and the centrifugation time is preferably 30min. The freeze-drying time of the present invention is preferably 28 hours. In the present invention, the source of the rice bran is not particularly limited, and conventional rice bran in the field is preferably used. The present invention preferably further includes drying and pulverizing the rice bran before the mixing.

[0021] The present invention also provides the application of the mitochondrial protective agent in the preparation of a medicament for protecting cell mitochon...

Embodiment 1

[0030] Extraction steps:

[0031] 1. Drying and grinding of rice bran;

[0032] 2. Add 200ml ddH to 20g rice bran 2 O, boiled for 3 hours, cooled, centrifuged at 8000g for 30 minutes to get the supernatant, and the supernatant was frozen (-80°C) for more than 12 hours, and put on a freeze dryer (freeze-dried for 28 hours);

[0033] 3.20g of rice bran extract yields 3.6g of extract.

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Abstract

The invention provides a mitochondrial protective agent and application thereof, and relates to the technical field of cell protection. The invention provides the mitochondrial protective agent, application thereof in preparation of a medicament and the corresponding medicament. According to the invention, a rice bran extract is used for protecting the mitochondrial function of retinal cells, andwhen the usage amount of the rice bran extract is not higher than 150 micrograms / ml, no cytotoxicity is generated, and the ATP production function and electron transfer chain of the cell mitochondriacan be significantly improved.

Description

technical field [0001] The invention belongs to the technical field of cell protection, and in particular relates to a mitochondrial protective agent and its application. Background technique [0002] Mitochondria is the main site for oxidative phosphorylation and synthesis of adenosine triphosphate (ATP) in cells. Since adenosine triphosphate is the energy source for cellular activities, mitochondria are also known as cellular energy factories. In addition to providing energy for cells, mitochondria are also involved in processes such as cell differentiation, cell information transmission, and cell apoptosis, and have the ability to regulate cell growth cycles. However, under the stimulation of ultraviolet light, there is a certain damage to the mitochondria, especially the damage to the mitochondria of retinal cells, which reduces the generation of ATP and the role of the electron transport chain. Contents of the invention [0003] In view of this, the purpose of the p...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N5/079
CPCC12N5/0621C12N2500/76
Inventor 施丹玉刘宁和
Owner 尚禾粒线体生物科技(深圳)有限公司