A kind of preparation method of Qinghuo tablet

Abstract

The invention provides a preparation method of Qinghuo Tablets, which comprises the following steps: S1, take rhubarb and gypsum, pulverize them into fine powder, and sieve; take Daqing leaves and add water to decoct them for more than 2 times, combine the decoctions, filter, and concentrate to thick paste, add rhubarb, gypsum fine powder and auxiliary materials, mix well, and make granules; S2, preparation of menthol inclusion compound: (1) preparation of menthol solution: get menthol, add ethanol solution and stir to dissolve; (2 ) Preparation of β-cyclodextrin solution: take water at 45-65°C, add β-cyclodextrin, start the colloid mill, and grind for 10-45 minutes; (3) Mixing of the two solutions: mix menthol solution and β-cyclodextrin ‑The cyclodextrin solution is mixed, the colloid mill is started, and the emulsion is ground into an emulsion; S3, the granules in the S1 step are mixed with the emulsion obtained in the S2 step, dried, pressed into tablets, and coated to obtain Qinghuo Tablets. The Qinghuo tablet prepared by the invention not only has high inclusion rate and stable menthol content, but also has short disintegration time limit, better formability and good taste.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a preparation method of Qinghuo tablets. Background technique [0002] Qinghuo Tablet is a tablet made from Folium Folium Folium, Rhubarb, Gypsum, and Menthol. It is recorded in the second volume of "Ministry of Health Drug Standards of the People's Republic of China Chinese Medicine Prescriptions". It has the functions of clearing away heat, purging fire and laxative Efficacy, clinically used for sore throat, toothache, dizziness, mouth and nose sores, wind-fire red eyes, constipation and other diseases. Menthol is one of the main active ingredients of Qinghuo Tablets. Menthol has good sweating, antipyretic, antibacterial, antiviral, choleretic and other effects. The menthol contained in this medicine is an active ingredient that can stimulate skin or mucous membranes. Cooling sensation to relieve discomfort and pain. [0003] Menthol is a saturated cyclic alcohol ob...

AI Technical Summary

Problems solved by technology

In this patent, although the stability of Qinghuo Tablet prepared by menthol inclusion compound has been improved, it is still poor, the bioavailability is not high, and the preparation method has a long inclusion time, low inclusion rate, and the dissolution of menthol and inclusion agent Poor performance, the disintegration time limit of the prepared Qinghuo tablet is long, and the production cost is high

And in this method, dissolve menthol with ethyl acetate, there is the risk of ethyl acetate residue, and can affect the mouthfeel of final product

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