A intestinal preparation medicinal composition for cleaning intestinal tract and preparation method thereof

A bowel preparation and bowel cleansing technology, applied in the field of biomedicine, can solve the problems of unstable bowel cleansing effect and poor taste of cleansing drugs, and achieve the purpose of enhancing the nerve activity of the intestinal wall, increasing the water content of the intestinal lumen, and enhancing the bowel function. The effect of peristalsis

Active Publication Date: 2021-10-12
唐传生物科技(厦门)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to provide a intestinal cleansing pharmaceutical composition for bowel preparation and its preparation method, which can solve the problems of poor taste and unstable bowel cleansing effect of existing intestinal cleansing drugs, and can effectively reduce the intestinal cleansing effect. Adverse reactions to the process

Method used

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  • A intestinal preparation medicinal composition for cleaning intestinal tract and preparation method thereof
  • A intestinal preparation medicinal composition for cleaning intestinal tract and preparation method thereof
  • A intestinal preparation medicinal composition for cleaning intestinal tract and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0038]A preparation method of intestinal preparation pharmaceutical composition, comprising the following steps:

[0039] S1. Obtain the raw material mother liquor containing xylose and L-arabinose. After the raw material mother liquor is diluted and decolorized, it is inoculated with specific yeast, and after specific yeast fermentation, xylose is converted into xylitol, and L-arabinose is removed at the same time. Purity impurities; the raw material mother liquor is derived from the plant extract of lignocellulose; the raw material mother liquor used in the present invention is purchased from Haining Zhitao Biotechnology Co., Ltd.;

[0040] S2. After the fermentation is over, the bacterial cells are recovered by centrifugation, and the fermentation broth is subjected to ion exchange, vacuum concentration and chromatographic separation to obtain L-arabinose sugar solution and xylitol solution respectively;

[0041] S3. The L-arabinose sugar solution obtained after separation ...

Embodiment 1

[0050] In order to better understand the present invention, the present invention will be further described below through rat experiments.

[0051] 1. Rat defecation comparison test

[0052] The experimental rats used in the present invention were purchased from the Experimental Animal Center of Xiamen University, license number SYXK (Fujian) 2018-0010.

[0053] 60 SD grade rats, 55 days old, body weight 200g ± 30g, half male and half male, were randomly divided into normal control group (10 rats), positive control group (L-arabinose, 10 rats), positive control group (xylitol , 10) and the experimental group (30), wherein the experimental group is divided into experimental group ① (95wt% L-arabinose + 5wt% xylitol, 10), experimental group ② (50wt% L-arabinose + 50wt% % xylitol, 10 rats), experimental group ③ (5wt% L-arabinose+95wt% xylitol, 10 rats). Oral gavage of drinking water for the normal control group; gavage of L-arabinose and xylitol at 3g / kg for the positive contro...

Embodiment 2

[0071] Typical clinical example

[0072] How the drug is taken:

[0073] Dissolve 18g of a pharmaceutical composition containing 95wt% L-arabinose and 5wt% xylitol (3g / bag, 6 bags in total) with a small amount of water before dinner the day before the inspection, and take 300-500ml of water; check the next day For the first 4 hours, continue to take the solution containing 18g of the pharmaceutical composition containing L-arabinose and xylitol, and increase the drinking water to 1000ml. Fast on the day of the examination, walk around appropriately to promote excretion until the end of the examination.

[0074] 1 Zhang XX, female, 38 years old, usually has symptoms of constipation, occasionally blood in the stool, intends to do a colonoscopy to check the intestinal tract to determine whether there is intestinal disease. Colonoscopy was performed after taking L-arabinose and xylitol intestinal preparation pharmaceutical composition according to the instructions. Description o...

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Abstract

The invention discloses a bowel preparation pharmaceutical composition for cleaning the intestinal tract and a preparation method thereof. The bowel preparation pharmaceutical composition comprises the following components in parts by weight: 65-99 parts of L-arabinose and 1 -15 parts of xylitol; the purity of the L-arabinose ≥99%; the purity of the xylitol ≥99%; the intestinal preparation pharmaceutical composition is made into tablets, capsules, oral liquid, Granules, powders or syrups; self-selected specific Candida tropicalis can selectively convert xylose into xylitol, and the yeast can also utilize impurities in raw materials other than L-arabinose, especially in The impurities whose chromatographic peak time overlaps with the peak of L-arabinose can be efficiently separated from L-arabinose by using impurities as nutrients, and achieve the effect of obtaining two products of xylitol and L-arabinose at the same time from one material. Production cost advantage.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to an intestinal preparation medicinal composition for cleaning the intestinal tract and a preparation method thereof. Background technique [0002] Colonoscopy is the most effective method for diagnosing and treating diseases of the colon. The quality of bowel preparation will directly affect the diagnosis and treatment effect of colonoscopy. Inadequate bowel preparation will not only increase the operation time of colonoscopy, affect the image quality and treatment effect, but may even cause serious situations such as intestinal injury. Effective intestinal preparation is the key to the success of colonoscopy. A clean intestinal tract provides guarantee for insertion, observation, diagnosis and treatment, and even surgical treatment, and can also reduce the psychological pressure and burden of patients. [0003] Bowel preparation methods are different, and the effects are also differen...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7004A61K31/047A61P1/10
CPCA61K31/047A61K31/7004A61P1/10A61K2300/00
Inventor 叶梓林卫军石国良洪诗群蔡许彬王羽娟
Owner 唐传生物科技(厦门)有限公司
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