Application of SIRT1 inhibitors in side effects caused by combined use of VEGFR inhibitors and immune checkpoint inhibitors
1. The technology of SIRT1 and inhibitors, which is applied in the field of medicine, can solve problems such as different, complicated pathogenesis, and affecting the quality of life of patients, and achieve the effect of solving side effects
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[0028] SIRT1 inhibitors can prevent / treat hand-foot syndrome caused by VEGF / VEGFR inhibitors + PD-1 / PD-L1 inhibitors
[0029] Rat animal models were constructed, and the VEGFR / VEGF inhibitors shown in Table 1 were administered to 8-week-old female SD rats by intragastric administration every day, and pembrolizumab was intravenously infused on the 7th, 10th, and 13th days ( 5mg / kg) or nivolumab (10mg / kg) in aqueous solution, after a few days, the paws of the rats showed symptoms of hand-foot syndrome (such as figure 1 shown). Similar to humans, rats will develop symptoms of hand-foot syndrome after oral administration of the VEGF / VEGFR inhibitor + PD-1 / PD-L1 inhibitor, and the symptoms are very similar. Therefore, rats are a very good animal model for simulating the side effects (such as hand-foot syndrome) caused by VEGFR / VEGF inhibitors + PD-1 / PD-L1 inhibitors.
[0030] After feeding and adapting the rats (about 200g) for one week, they were divided into groups, 10 in each ...
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