Application of SIRT1 inhibitors in side effects caused by combined use of VEGFR inhibitors and immune checkpoint inhibitors

1. The technology of SIRT1 and inhibitors, which is applied in the field of medicine, can solve problems such as different, complicated pathogenesis, and affecting the quality of life of patients, and achieve the effect of solving side effects

Inactive Publication Date: 2020-08-25
上海馨颖生物技术有限公司
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AI Technical Summary

Problems solved by technology

[0007] However, while the combination therapy of anti-angiogenic drugs and immune checkpoint inhibitors has good curative effect, it can also cause a series of serious side effects, such as hand-foot syndrome or hand-foot skin reaction
Such side effects seriously affect the quality of life of patients
[0008] At present, the pathogenesis of side effects (such as hand-foot syndrome or hand-foot skin reaction) caused by the combination therapy of anti-angiogenic drugs and immune checkpoint inhibitors is relatively complicated. The side effects are slightly different. In the prior art, there is no effective treatment for the side effects caused by the combination of VEGFR and PD-1 / PD-L1 inhibitors. It is urgent to solve this problem

Method used

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  • Application of SIRT1 inhibitors in side effects caused by combined use of VEGFR inhibitors and immune checkpoint inhibitors
  • Application of SIRT1 inhibitors in side effects caused by combined use of VEGFR inhibitors and immune checkpoint inhibitors
  • Application of SIRT1 inhibitors in side effects caused by combined use of VEGFR inhibitors and immune checkpoint inhibitors

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Experimental program
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Effect test

Embodiment 1-11

[0028] SIRT1 inhibitors can prevent / treat hand-foot syndrome caused by VEGF / VEGFR inhibitors + PD-1 / PD-L1 inhibitors

[0029] Rat animal models were constructed, and the VEGFR / VEGF inhibitors shown in Table 1 were administered to 8-week-old female SD rats by intragastric administration every day, and pembrolizumab was intravenously infused on the 7th, 10th, and 13th days ( 5mg / kg) or nivolumab (10mg / kg) in aqueous solution, after a few days, the paws of the rats showed symptoms of hand-foot syndrome (such as figure 1 shown). Similar to humans, rats will develop symptoms of hand-foot syndrome after oral administration of the VEGF / VEGFR inhibitor + PD-1 / PD-L1 inhibitor, and the symptoms are very similar. Therefore, rats are a very good animal model for simulating the side effects (such as hand-foot syndrome) caused by VEGFR / VEGF inhibitors + PD-1 / PD-L1 inhibitors.

[0030] After feeding and adapting the rats (about 200g) for one week, they were divided into groups, 10 in each ...

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Abstract

The invention belongs to the technical field of medicines, relates to application of SIRT1 inhibitors in the side effects caused by the combined use of VEGFR inhibitors and immune checkpoint inhibitors, and particularly refers to the application of the SIRT1 inhibitors in the prevention and / or treatment of the side effects caused by the combined use of the VEGFR inhibitors and PD-1 / PD-L1 inhibitordrugs. Compared with the prior art, the side effects caused by the combined use of the VEGFR inhibitors and the PD-1 / PD-L1 inhibitor drugs can be cured.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to the application of SIRT1 inhibitors on the side effects caused by the combination of VEGFR inhibitors and immune checkpoint inhibitors, especially the application of SIRT1 inhibitors in the prevention and / or treatment of VEGFR inhibitors and PD-1 / PD-1 The application of side effects caused by the combination of L1 inhibitor drugs. Background technique [0002] Cancer is caused by abnormal proliferation of cells. The current traditional methods of treating cancer include surgery, radiotherapy, chemotherapy, immunotherapy, and gene therapy. The reasons affecting the occurrence and development of tumors are very complex, and drug resistance and tumor recurrence are prone to occur during treatment, making tumor treatment more difficult. [0003] Immune checkpoint inhibitors (PD-1 / PD-L1 inhibitors) are common anticancer drugs. PD-1 / PD-L1 inhibitors specifically recognize and bind to PD-1 on th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/06A61K31/455A61P35/00A61P17/00
CPCA61K31/455A61K45/06A61P17/00A61P35/00
Inventor 刘文杰林微微
Owner 上海馨颖生物技术有限公司
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