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Application of dihydroartemisinin in preparation of medicine for preventing and treating hyperammonemia

A kind of technology of dihydroartemisinin and medicine preparation, applied in the field of medicine

Active Publication Date: 2020-09-08
CHINA AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far no research has reported its role in the prevention / treatment of hyperammonemia

Method used

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  • Application of dihydroartemisinin in preparation of medicine for preventing and treating hyperammonemia
  • Application of dihydroartemisinin in preparation of medicine for preventing and treating hyperammonemia
  • Application of dihydroartemisinin in preparation of medicine for preventing and treating hyperammonemia

Examples

Experimental program
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Embodiment

[0028] Preparation of basal diet for adult zebrafish

[0029] Adult zebrafish rations were prepared with dextrin as the sugar source, casein and gelatin as the protein source, soybean oil as the fat source, and 0.25% or 0.5% dihydroartemisinin (Sinopharm Group Chemical Reagent Beijing Co., Ltd.) was used as the diet of the treatment group. The composition and chemical analysis values ​​of the experimental diet are shown in Table 1-1. Each feed raw material is pulverized and passed through a 40-mesh sieve. After mixing evenly, about 40% of water is added, extruded into strips, dried and crushed into pellets of 1-2mm, and stored in a -20°C refrigerator for later use.

[0030] Table 1 Test diet composition and chemical analysis value (%, feeding basis)

[0031] Items DhA 0% DHA 0.25% DHA 0.5% Raw materialIngredients Casein 40.00 40.00 40.00 Gelatin 10.00 10.00 10.00 Dextrin 35.00 35.00 35.00 Soybean oil 6.00 6.00 6.00 ...

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Abstract

The invention provides application of dihydroartemisinin in preparation of a medicine. The medicine is used for preventing or treating hyperammonemia. Therefore, a theoretical basis and application value are provided for human or animal hyperammonemia treatment or adjuvant therapy drugs.

Description

technical field [0001] The present invention relates to the field of medicine. Specifically, the present invention relates to the use of dihydroartemisinin in the preparation of drugs for the prevention and treatment of hyperammonemia. Background technique [0002] Ammonia is a colorless gas with a strong pungent odor and the molecular formula is NH 3 (MW 17), which is also one of the main components of smog, can form secondary organic aerosols, thereby increasing the threat of smog to public health. Under normal circumstances, ammonia in the body mainly synthesizes secondary metabolites-urea and glutamine through the liver urea cycle, and then excretes the metabolites through the kidneys for ammonia detoxification. However, in the case of liver disease or impaired function, the ammonia detoxification process is blocked, which can easily cause hyperammonemia. High concentrations of ammonia can cause destructive effects on multiple organ systems in the human body, such as ...

Claims

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Application Information

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IPC IPC(8): A61K31/357A61K36/282A61P39/02
CPCA61K31/357A61K36/282A61P39/02
Inventor 武振龙杨鹰李帅
Owner CHINA AGRI UNIV
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