Unlock instant, AI-driven research and patent intelligence for your innovation.

A kind of system and method for preparing valsartan and amlodipine tablets

A valsartan amlodipine tablet and feeding technology, which is applied in the field of valsartan amlodipine tablet preparation, can solve the problems of difficult mixing, exceeding a single dose, and the blood drug concentration cannot reach an effective concentration, and achieves high efficiency. well-mixed effect

Active Publication Date: 2021-12-21
浙江花园药业有限公司
View PDF10 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The raw material of valsartan is white powder, which is hygroscopic and not easy to mix, and the prescription ratio of the raw material of valsartan and amlodipine besylate is 80:5. General industrial production uses three-dimensional mixer and wet granulator to mix, but the two raw materials It is easy to stick during the mixing process, and the mixing uniformity is not good, which leads to the content uniformity of valsartan and amlodipine tablets exceeding the range stipulated in the "Chinese Pharmacopoeia"
If the content is too high, the single dose will exceed the safe dose; if the content is too low, the blood drug concentration will not reach the effective concentration, and the therapeutic effect will not be achieved, which will cause great risks in the clinical administration process

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of system and method for preparing valsartan and amlodipine tablets
  • A kind of system and method for preparing valsartan and amlodipine tablets
  • A kind of system and method for preparing valsartan and amlodipine tablets

Examples

Experimental program
Comparison scheme
Effect test

specific Embodiment approach 1

[0041] Combine below Figure 1-12 Description of this embodiment, a system for preparing valsartan and amlodipine tablets, including a device bracket 1, a clamping mechanism 2, a stirring box 3, a stirring mechanism 4, a funnel 5, a replacement mechanism 6, a feeding bracket 7, a feeding Mechanism 8 and closing mechanism 9, the middle part of described device support 1 is fixedly connected with clamping mechanism 2, is clamped with mixing box 3 on clamping mechanism 2, and the upper end of described device support 1 middle part is fixedly connected with stirring mechanism 4, and stirring mechanism 4 Located on the upper side of the mixing box 3, the device bracket 1 is fixedly connected with a funnel 5, the front end of the device bracket 1 is rotatably connected with a replacement mechanism 6, the funnel 5 is located on the upper side of the replacement mechanism 6, and the rear end of the device bracket 1 is fixedly connected There is a feeding bracket 7, the feeding bracket...

specific Embodiment approach 2

[0042] Combine below Figure 1-12 Describe this embodiment, this embodiment will further explain Embodiment 1, the device bracket 1 includes a side bracket 101, a support frame 102, a support plate I 103, a support plate II 104 and a mounting plate 105, and the side bracket 101 is provided with two, two A support frame 102 is fixedly connected between the middle parts of each side bracket 101, a support plate I 103 is fixedly connected to the front ends of the two side supports 101, a support plate II 104 is fixedly connected to the rear ends of the two side supports 101, and the two support plates A mounting plate 105 is fixedly connected between the upper ends of II 104 .

specific Embodiment approach 3

[0043] Combine below Figure 1-12 This embodiment will be described. This embodiment will further describe the second embodiment. The clamping mechanism 2 includes a clamping plate 201, a clamping sliding column 202, a spring baffle 203, a clamping sliding cylinder 204, a wheel frame 205, Rotating wheel 206, telescopic mechanism I 207, connecting plate 208 and swing motor 209, the two ends of clamping plate 201 are all fixedly connected with clamping sliding column 202, the angle between two clamping sliding columns 202 is 90 °, two Spring baffles 203 are fixedly connected to the clamping sliding columns 202, eight clamping discs 201 are provided, and each of the eight clamping discs 201 forms a group of four, and the corresponding two clamping sliding columns 202 slide A clamping slide 204 is connected, and a compression spring II is fixedly connected between the clamping slide 204 and the corresponding spring baffle 203. The inner side of each clamping disk 201 is fixedly co...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The present invention relates to the preparation of pharmaceutical preparations, more specifically a system and method for preparing valsartan and amlodipine tablets, comprising step 1: placing valsartan and amlodipine in a mixing drum in a weight ratio of 80:5 Inside, place the raw materials of valsartan and amlodipine in two feeding boxes respectively, adjust the sliding height of the feeding bottom plate in the feeding tank, so that the feeding bracket rotates a circle to supply the ratio of raw materials to the mixing box The weight ratio of valsartan and amlodipine is 80:5; step 2: start the stirring mechanism to stir the raw materials in the mixing box, and after the stirring is completed, the clamping mechanism will swing and pour the raw materials in the mixing box into the funnel. The raw material falls on the replacement mechanism; Step 3: When the replacement mechanism rotates, it drives the feeding bracket to rotate a circle for feeding, the clamping mechanism resets and pushes the closing mechanism to move, and the raw materials in the feeding bracket fall into the mixing box; step Four: Compression, coating and testing.

Description

technical field [0001] The invention relates to the preparation of pharmaceutical preparations, more specifically a system and method for preparing valsartan and amlodipine tablets. Background technique [0002] Valsartan and Amlodipine Tablets belong to a compound preparation and are mainly used clinically to treat essential hypertension, which can help control blood pressure and promote blood pressure to return to normal levels. Valsartan and Amlodipine Tablets contain two antihypertensive active ingredients, of which valsartan belongs to angiotensin antagonist drugs, while amlodipine belongs to calcium channel blocker drugs, so although these two ingredients both have antihypertensive However, at the same time, it has a complementary effect on the control of blood pressure. Therefore, compared with ordinary monotherapy, valsartan and amlodipine tablets are more effective in dealing with high blood pressure. significantly. [0003] The raw material of valsartan is white ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): B01F11/00B01F15/04B01F15/02
CPCB01F31/443B01F35/717B01F35/881B01F2101/22
Inventor 付长华吴迎庆陈兴加方焱琳汪柳明
Owner 浙江花园药业有限公司