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Method for Improving Anti-platelet Activation Function of Polyurethane Material

A polyurethane material, anti-platelet technology, applied in the field of medical biomaterials, can solve the problems of low water solubility and poor bioavailability of baicalein, and achieve the effects of improving blood compatibility, easy amplification, and wide application fields

Active Publication Date: 2022-03-29
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, baicalein has the problems of low water solubility and poor bioavailability

Method used

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  • Method for Improving Anti-platelet Activation Function of Polyurethane Material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Weigh 0.25g of bovine serum albumin and dissolve it in 5g of deionized water, and weigh 20mg of baicalein and dissolve it in 20ml of absolute ethanol. Under vigorous stirring, the baicalein ethanol solution was added dropwise to the bovine serum albumin aqueous solution at 2 ml / min, and stirred overnight. The sample was obtained by high-speed centrifugation at 12000rmp, and the sample was pre-frozen and freeze-dried to obtain baicalein nanoparticles. In Tris-HCl with a pH of 9.5, dopamine and baicalein nanoparticles were added at concentrations of 4.5 mg / mL and 10 mg / mL, respectively, and polyurethane was treated in the reaction solution for 30 h while stirring. After the reaction, the sample was fully washed three times with distilled water, and dried under vacuum at 40°C overnight to obtain the sample. The surface-modified polyurethane has good anti-platelet adhesion effect.

Embodiment 2

[0028] Weigh 0.45g of bovine serum albumin and dissolve it in 5g of deionized water, and weigh 10mg of baicalein and dissolve it in 20ml of absolute ethanol. Under vigorous stirring, the baicalein ethanol solution was added dropwise to the bovine serum albumin aqueous solution at a rate of 1.5 ml / min, and stirred overnight. The sample was obtained by high-speed centrifugation at 12000rmp, and the sample was pre-frozen and freeze-dried to obtain baicalein nanoparticles. In Tris-HCl with a pH of 8.5, dopamine and baicalein nanoparticles were added at concentrations of 4.5 mg / mL and 0.5 mg / mL, respectively, and polyurethane was treated in the reaction solution for 24 h while stirring. After the reaction, the sample was fully washed three times with distilled water, and dried under vacuum at 40°C overnight to obtain the sample. The surface-modified polyurethane has good anti-platelet adhesion effect, see the attached figure 1 shown.

Embodiment 3

[0030] Weigh 0.25g of bovine serum albumin and dissolve it in 5g of deionized water, and simultaneously weigh 20mg of baicalein and dissolve it in 20ml of absolute ethanol. Under vigorous stirring, the baicalein ethanol solution was added dropwise to the bovine serum albumin aqueous solution at 1 ml / min, and stirred overnight. The sample was obtained by high-speed centrifugation at 15000rmp, and the sample was pre-frozen and freeze-dried to obtain baicalein nanoparticles. In Tris-HCl with a pH of 8, dopamine and baicalein nanoparticles were added at concentrations of 4.5 mg / mL and 20 mg / mL, respectively, and polyurethane was treated in the reaction solution for 15 h while stirring. After the reaction, the sample was fully washed three times with distilled water, and dried under vacuum at 40°C overnight to obtain the sample. The surface-modified polyurethane has good anti-platelet adhesion effect.

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Abstract

The invention discloses a method for a polyurethane material to obtain anti-platelet activation function. The method comprises the following steps: encapsulating baicalein with bovine serum albumin to obtain baicalein nanoparticles; mixing baicalein nanoparticles and dopamine solution, and carrying out surface grafting reaction on medical polyurethane; fully washing and drying the modified medical polyurethane material, Get the finished product. The method of the invention makes full use of the property that baicalein is easily soluble in ethanol solution, and at the same time adopts a bovine serum albumin coating method to maintain the activity of baicalein. The process of the method of the invention is simple, the reaction conditions are easy to protect the activity of the traditional Chinese medicine, and the process is easy to enlarge to realize large-scale production.

Description

technical field [0001] The invention relates to medical biomaterial technology, in particular to a method for improving anti-platelet activity and biocompatibility on the surface of medical polyurethane materials based on active ingredients of traditional Chinese medicine. Background technique [0002] Medical polymers are directly used in the human body and are closely related to human health. Therefore, there are strict requirements for medical polymers, and biocompatibility is one of the key indicators of medical materials. Medical polymer materials used to manufacture artificial organs or devices in contact with blood are in direct contact with blood, such as artificial blood vessels, heart valves, stents and catheters, etc., must also have good blood compatibility, such as not causing blood coagulation, not destroying Red blood cells, do not change blood protein, do not destroy platelets, etc. The surface of biomaterials is in direct contact with human blood or tissues...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/18A61L27/28A61L27/34A61L27/50A61L27/54A61L31/06A61L31/08A61L31/10A61L31/14A61L31/16A61L33/00A61L33/06
CPCA61L27/18A61L27/28A61L27/34A61L27/50A61L27/54A61L31/06A61L31/08A61L31/10A61L31/14A61L31/16A61L33/0011A61L33/0041A61L33/0082A61L33/068A61L2400/12A61L2300/42A61L2400/18A61L2420/02A61L2420/06C08L75/04C08L89/00
Inventor 周雪锋顾宁
Owner SOUTHEAST UNIV
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