Application of SOX2 targeted drug to inhibiting proliferation of lung cancer stem cells

Abstract

The invention provides an application of an SOX2 targeted drug to inhibiting proliferation of lung cancer stem cells. The SOX2 targeted drug is a scutellaria barbata D.Don extract; and the SOX2 targeted drug interferes with proliferation of lung cancer stem cells and multidrug resistance thereof through targeted inhibition of SOX2. The drug has toxic and side effects, and is tolerable and easy totake orally and absorb. Cell proliferation, cell apoptosis and cell cycle arrest assays prove that a polypeptide provided by the invention can effectively inhibit proliferation of tumor stem cells andthe drug has no obvious tissue damage or toxicity to mice at high doses.

Description

technical field [0001] The invention relates to the application of a SOX2-targeted drug to inhibit the proliferation of lung cancer stem cells, in particular to the application of barbatae barbata extracts to inhibit the growth of lung cancer cells and interfere with the proliferation of stem cells in vivo and in vitro by targeting the stem cell transcription factor SOX2. Background technique [0002] Lung cancer is a malignant tumor with the highest morbidity and mortality in my country. Conventional clinical treatment methods include surgical resection, targeted therapy, immunotherapy, and radiotherapy and chemotherapy. Although individualized targeted therapy such as EGFR and ALK inhibitors has achieved good therapeutic effects, patients with mutant EGFR and ALK only account for about 15% of NSCLC patients, and most patients will still develop drug resistance after 1 year of medication. Although the immunotherapy carried out in recent years has made great progress, there...

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And it has a certain anti-hepatitis B virus effect, which can be used in patients with hepatitis B, but its specific mechanism is unknown

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